ENSDARG00000103747


Danio rerio

Features
Gene ID: ENSDARG00000103747
  
Biological name :cav1
  
Synonyms : cav1 / caveolin 1
  
Possible biological names infered from orthology : P49817 / Q03135
  
Species: Danio rerio
  
Chr. number: 25
Strand: 1
Band:
Gene start: 18563476
Gene end: 18577586
  
Corresponding Affymetrix probe sets: Dr.20769.1.A1_at (Zebrafish Array)   Dr.23513.1.S1_at (Zebrafish Array)   Dr.5678.1.S1_at (Zebrafish Array)   Dr.5678.1.S1_s_at (Zebrafish Array)   Dr.6287.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000134599
Ensembl peptide - ENSDARP00000141857
NCBI entrez gene - 323695     See in Manteia.
RefSeq - NM_001024162
RefSeq Peptide - NP_001019333
swissprot - Q6YLH8
swissprot - Q6YLH9
ZFIN ID - ZDB-GENE-030131-2415
Ensembl - ENSDARG00000103747
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CAV1ENSGALG00000043287Gallus gallus
 CAV1ENSG00000105974Homo sapiens
 Cav1ENSMUSG00000007655Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cav3 / caveolin 3 / P51637* / P56539*ENSDARG0000002414157
zgc:172270ENSDARG0000000363232
cav2 / caveolin 2 / P51636* / Q9WVC3*ENSDARG0000005200029
zgc:158296ENSDARG0000007092328


Protein motifs (from Interpro)
Interpro ID Name
 IPR001612  Caveolin
 IPR018361  Caveolin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0048884 neuromast development IMP
 biological_processGO:0050688 regulation of defense response to virus IMP
 biological_processGO:0060036 notochord cell vacuolation IMP
 biological_processGO:0060038 cardiac muscle cell proliferation IMP
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway IMP
 biological_processGO:0061026 cardiac muscle tissue regeneration IMP
 biological_processGO:0070836 caveola assembly IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008013 beta-catenin binding IDA


Pathways (from Reactome)
Pathway description
NOSTRIN mediated eNOS trafficking
Basigin interactions
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain structure , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary aplastic , abnormal
Show

 ZFA:0000077 tail bud tail bud protruding , abnormal
Show

 ZFA:0000105 epidermis epidermis actin cytoskeleton disorganized , abnormal
epidermis cell size , abnormal
Show

 ZFA:0000107 eye eye morphology , abnormal
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 ZFA:0000114 heart heart increased size , abnormal
heart edematous , abnormal
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 ZFA:0000135 notochord notochord malformed , abnormal
notochord undulate , abnormal
notochord caveola decreased amount , abnormal
notochord caveola decreased mass density , abnormal
notochord cell increased distance notochord cell, abnormal
notochord basement membrane increased thickness , abnormal
notochord basement membrane disorganized , abnormal
notochord vacuole circular , abnormal
notochord vacuole decreased size , abnormal
notochord cell vacuolated , abnormal
notochord structure , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium disorganized , abnormal
retinal pigmented epithelium pigment granule movement quality , abnormal
retinal pigmented epithelium morphology , abnormal
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 ZFA:0000155 somite somite disorganized , abnormal
somite myofibril absent , abnormal
somite caveola absent , abnormal
somite shape , abnormal
somite decreased length , abnormal
somite myofibril disorganized , abnormal
Show

 ZFA:0000396 nervous system nervous system vacuolated , abnormal
nervous system caveola absent , abnormal
nervous system decreased size , abnormal
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 ZFA:0000671 horizontal myoseptum horizontal myoseptum aplastic , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
posterior lateral line neuromast neuromast hair cell decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism anterior-posterior axis decreased length , abnormal
whole organism curved ventral , abnormal
whole organism wholly dorsalized , abnormal
whole organism decreased life span , abnormal
Show

 ZFA:0001114 head head flat , abnormal
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 ZFA:0001115 trunk trunk curved , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region bent , abnormal
post-vent region curved ventral , abnormal
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 ZFA:0001261 ventricular system ventricular system structure , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature spatial pattern , abnormal
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 ZFA:0001319 myocardium myocardium tissue regeneration process quality , abnormal
Show

 ZFA:0001472 anterior lateral line neuromast anterior lateral line neuromast decreased amount , abnormal
Show

 ZFA:0005037 post-vent vasculature post-vent vasculature spatial pattern , abnormal
Show

 ZFA:0009041 peridermal cell peridermal cell caveola absent , abnormal
Show

 ZFA:0009091 melanocyte melanocyte pigment granule movement quality , abnormal
Show

 ZFA:0009114 muscle cell muscle cell sarcoplasmic reticulum disorganized , abnormal
muscle cell myofibril disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / complex
 ENSDARG00000100825 calm2a / calm2b / calm3a / Q6PI52 / calmodulin 2a (phosphorylase kinase, delta)  / complex






 

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