ENSDARG00000010478


Danio rerio

Features
Gene ID: ENSDARG00000010478
  
Biological name :hsp90aa1.1
  
Synonyms : heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / hsp90aa1.1 / Q90474
  
Possible biological names infered from orthology : heat shock protein 90 alpha family class A member 1 / Heat shock protein HSP 90-alpha / HSP90AA1 / P07900 / P07901
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 53982317
Gene end: 54012043
  
Corresponding Affymetrix probe sets: Dr.610.1.S1_at (Zebrafish Array)   Dr.610.2.S1_a_at (Zebrafish Array)   NM_131328_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000022302
Ensembl peptide - ENSDARP00000138112
NCBI entrez gene - 30591     See in Manteia.
RefSeq - NM_131328
RefSeq Peptide - NP_571403
swissprot - Q90474
ZFIN ID - ZDB-GENE-990415-94
Ensembl - ENSDARG00000010478
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HSP90AA1ENSGALG00000033212Gallus gallus
 P07900ENSG00000080824Homo sapiens
 P07901ENSMUSG00000021270Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hsp90b1 / heat shock protein 90, beta (grp94), member 1 / P08113* / P14625* / heat shock protein 90 beta family member 1*ENSDARG0000000357045
trap1 / TNF receptor-associated protein 1 / Q12931*ENSDARG0000002431728


Protein motifs (from Interpro)
Interpro ID Name
 IPR001404  Heat shock protein Hsp90 family
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR019805  Heat shock protein Hsp90, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR020575  Heat shock protein Hsp90, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0010038 response to metal ion IDA
 biological_processGO:0014866 skeletal myofibril assembly IMP
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0030240 skeletal muscle thin filament assembly IMP
 biological_processGO:0030241 skeletal muscle myosin thick filament assembly IMP
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISS
 biological_processGO:0048769 sarcomerogenesis IMP
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0050900 leukocyte migration IMP
 biological_processGO:0071688 striated muscle myosin thick filament assembly IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0031672 A band IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding ISS
 molecular_functionGO:0016887 ATPase activity ISS
 molecular_functionGO:0030235 nitric-oxide synthase regulator activity ISS
 molecular_functionGO:0051082 unfolded protein binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Regulation of actin dynamics for phagocytic cup formation
eNOS activation
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
EPHB-mediated forward signaling
Sema3A PAK dependent Axon repulsion
VEGFA-VEGFR2 Pathway
VEGFR2 mediated vascular permeability
Anchoring of the basal body to the plasma membrane
Neutrophil degranulation
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Downregulation of ERBB2 signaling
ESR-mediated signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye fused with eye , abnormal
eye mislocalised , abnormal
eye malformed , abnormal
eye decreased amount , abnormal
Show

 ZFA:0000155 somite somite U-shaped , abnormal
Show

 ZFA:0000236 mandibular muscle mandibular muscle refractivity , abnormal
Show

 ZFA:0000473 trunk musculature trunk musculature refractivity , abnormal
trunk musculature disorganized , abnormal
trunk musculature quality , abnormal
Show

 ZFA:0001056 myotome myotome striated muscle myosin thick filament decreased amount , abnormal
myotome striated muscle myosin thick filament absent , abnormal
myotome refractivity , abnormal
myotome striated muscle thin filament decreased amount , abnormal
myotome myofibril disorganized , abnormal
myotome Z disc disorganized , abnormal
myotome M band disorganized , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism immobile , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head necrotic , abnormal
Show

 ZFA:0001115 trunk trunk duplicated , abnormal
trunk anterior-posterior axis bifurcated , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
Show

 ZFA:0005145 muscle muscle myofibril morphology , abnormal
muscle morphology , abnormal
Show

 ZFA:0005277 skeletal muscle skeletal muscle Z disc disorganized , abnormal
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 ZFA:0009115 skeletal muscle cell skeletal muscle cell myofibril disorganized , abnormal
skeletal muscle cell M band disorganized , abnormal
skeletal muscle cell nucleus circular , abnormal
skeletal muscle cell myofibril decreased amount , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell striated muscle myosin thick filament disorganized , abnormal
slow muscle cell striated muscle thin filament disorganized , abnormal
slow muscle cell myosin filament disorganized , abnormal
slow muscle cell sarcomere decreased amount , abnormal
slow muscle cell myofibril disorganized , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell striated muscle myosin thick filament disorganized , abnormal
fast muscle cell striated muscle thin filament disorganized , abnormal
fast muscle cell myofibril disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000026294 erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *  / reaction / complex
 ENSDARG00000003022 limk1b / LIM domain kinase 1b / LIMK1* / P53667* / P53668* / LIM domain kinase 1*  / complex / reaction
 ENSDARG00000004906 stip1 / stress-induced phosphoprotein 1 / P31948* / Q60864*  / reaction / complex
 ENSDARG00000100825 calm2a / calm2b / calm3a / Q6PI52 / calmodulin 2a (phosphorylase kinase, delta)  / complex
 ENSDARG00000075121 hbegfa / heparin-binding EGF-like growth factor a / HBEGF* / Q06186* / Q99075* / heparin binding EGF like growth factor* / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like...  / reaction
 ENSDARG00000013719 gtse1 / G-2 and S-phase expressed 1 / Q8R080* / Q9NYZ3* / G2 and S phase-expressed protein 1 *  / complex / reaction
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / reaction / complex
 ENSDARG00000037284 ptges3a / prostaglandin E synthase 3a (cytosolic) / PTGES3* / Q9R0Q7* / Q15185* / prostaglandin E synthase 3*  / reaction / complex
 ENSDARG00000103747 cav1 / caveolin 1 / P49817* / Q03135*  / complex
 ENSDARG00000067976 ar / androgen receptor / P10275* / P19091*  / complex
 ENSDARG00000008818 hsf1 / heat shock transcription factor 1 / P38532* / Q00613* / heat shock factor 1*  / complex / reaction
 ENSDARG00000025032 nr3c1 / nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) / P04150* / nuclear receptor subfamily 3 group C member 1*  / complex
 ENSDARG00000016454 esr2a / estrogen receptor 2a / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *  / complex
 ENSDARG00000028396 fkbp5 / FK506 binding protein 5 / Q13451* / Q64378* / Peptidyl-prolyl cis-trans isomerase FKBP5 *  / complex / reaction
 ENSDARG00000034181 esr2b / estrogen receptor 2b / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *  / complex
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSDARG00000076554 cdkn1a / cyclin-dependent kinase inhibitor 1A / P38936* / P39689* / Cyclin-dependent kinase inhibitor 1 *  / complex / reaction
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex
 ENSDARG00000008447 fkbp4 / FK506 binding protein 4 / P30416* / Q02790* / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed*  / complex / reaction
 ENSDARG00000095322 fkbpl / FK506 binding protein like / O35450* / Q9UIM3*  / reaction / complex
 ENSDARG00000098112 btc / betacellulin, epidermal growth factor family member / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / reaction
 ENSDARG00000038835 ppid / peptidylprolyl isomerase D / Q08752* / Q9CR16* / peptidylprolyl isomerase D (cyclophilin D)*  / complex
 ENSDARG00000102082 nr3c2 / nuclear receptor subfamily 3, group C, member 2 / P08235*  / complex
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / reaction
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / reaction / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000056525 bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *  / complex
 ENSDARG00000058993 rock1 / Rho-associated, coiled-coil containing protein kinase 1 / Q13464*  / reaction
 ENSDARG00000104066 dnaja2 / DnaJ (Hsp40) homolog, subfamily A, member 2 / O60884* / Q9QYJ0* / DnaJ homolog subfamily A member 2 * / DnaJ heat shock protein family (Hsp40) member A2*  / reaction
 ENSDARG00000103542 O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*  / complex / reaction






 

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