ENSDARG00000098112


Danio rerio

Features
Gene ID: ENSDARG00000098112
  
Biological name :btc
  
Synonyms : betacellulin, epidermal growth factor family member / btc
  
Possible biological names infered from orthology : betacellulin / P35070 / Probetacellulin Betacellulin / Q05928
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 19368720
Gene end: 19389197
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000137815
Ensembl peptide - ENSDARP00000150018
Ensembl peptide - ENSDARP00000157166
Ensembl peptide - ENSDARP00000136928
NCBI entrez gene - 503869     See in Manteia.
NCBI entrez gene - 767639     See in Manteia.
RefSeq - NM_001160823
RefSeq - XM_005161175
RefSeq Peptide - NP_001154295
swissprot - A0A0R4INZ6
ZFIN ID - ZDB-GENE-050311-1
Ensembl - ENSDARG00000098112
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BTCENSGALG00000028608Gallus gallus
 BTCENSG00000174808Homo sapiens
 BtcENSMUSG00000082361Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tgfa / transforming growth factor, alpha / P01135* / P48030*ENSDARG0000005393916


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site
 IPR015497  Epidermal growth factor receptor ligand


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000026294 erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / reaction / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000098112 btc / betacellulin, epidermal growth factor family member / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / reaction / complex
 ENSDARG00000075121 hbegfa / heparin-binding EGF-like growth factor a / HBEGF* / Q06186* / Q99075* / heparin binding EGF like growth factor* / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like...  / reaction / complex
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction
 ENSDARG00000017947 ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / complex / reaction
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / reaction / complex
 ENSDARG00000074670 matk / megakaryocyte-associated tyrosine kinase / P42679*  / reaction / complex
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000059956 ptk6b / PTK6 protein tyrosine kinase 6b / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / reaction / complex






 

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