ENSDARG00000094673


Danio rerio

Features
Gene ID: ENSDARG00000094673
  
Biological name :rhoab
  
Synonyms : Q6DHM9 / ras homolog gene family, member Ab / rhoab
  
Possible biological names infered from orthology : P61586 / Q9QUI0 / ras homolog family member A / RHOA
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 25900049
Gene end: 25906026
  
Corresponding Affymetrix probe sets: Dr.7824.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000018377
Ensembl peptide - ENSDARP00000109720
Ensembl peptide - ENSDARP00000111732
Ensembl peptide - ENSDARP00000150768
NCBI entrez gene - 100006041     See in Manteia.
RefSeq - NM_212749
RefSeq - XM_021478160
RefSeq Peptide - NP_997914
swissprot - Q6DHM9
ZFIN ID - ZDB-GENE-040322-2
Ensembl - ENSDARG00000094673
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RHOAENSGALG00000003806Gallus gallus
 RHOAENSG00000067560Homo sapiens
 RhoaENSMUSG00000007815Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rhoac / Q7T2E8 / ras homolog gene family, member AcENSDARG0000011605894
rhoaa / Q6NUX8 / ras homolog gene family, member AaENSDARG0000002684594
rhocb / Q6DHE8 / ras homolog family member Cb / RHOC* / Q62159* / P08134* / ras homolog family member C* / Rho-related GTP-binding protein RhoC *ENSDARG0000001832893
rhoca / ras homolog family member Ca / RHOC* / Q62159* / P08134* / ras homolog family member C* / Rho-related GTP-binding protein RhoC *ENSDARG0000002130993
rnd3b / Rho family GTPase 3b / RND3* / P61588* / P61587* / Rho family GTPase 3* / Rho-related GTP-binding protein RhoE *ENSDARG0000000739650
rnd3a / Rho family GTPase 3a / RND3* / P61588* / P61587* / Rho family GTPase 3* / Rho-related GTP-binding protein RhoE *ENSDARG0000007679948
rnd1b / Rho family GTPase 1b / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *ENSDARG0000000421847
rnd2 / Rho family GTPase 2 / P52198* / Q9QYM5*ENSDARG0000007073546
rhof / ras homolog family member F / Q9HBH0* / Q8BYP3* / ras homolog family member F (in filopodia)* / ras homolog family member F, filopodia associated*ENSDARG0000005438946
rnd1a / Rho family GTPase 1a / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *ENSDARG0000003054745


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction IMP
 biological_processGO:0016055 Wnt signaling pathway IGI
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IGI
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0040001 establishment of mitotic spindle localization IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0044319 wound healing, spreading of cells ISS
 biological_processGO:0048840 otolith development IMP
 biological_processGO:1902766 skeletal muscle satellite cell migration ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Axonal growth inhibition (RHOA activation)
Rho GTPase cycle
PI3K/AKT activation
Axonal growth stimulation
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
G beta:gamma signalling through PI3Kgamma
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
PCP/CE pathway
G alpha (12/13) signalling events
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases activate KTN1
RHO GTPases Activate ROCKs
RHO GTPases Activate Formins
RHO GTPases Activate Rhotekin and Rhophilins
Ovarian tumor domain proteases
ERBB2 Regulates Cell Motility
Neutrophil degranulation
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SLIT2:ROBO1 increases RHOA activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000018 epiblast epiblast actin cap position , abnormal
epiblast mitotic spindle position , abnormal
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 ZFA:0000029 hindbrain hindbrain apoptotic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000077 tail bud tail bud opaque , abnormal
tail bud mislocalised , abnormal
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 ZFA:0000092 axis axis decreased length , abnormal
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 ZFA:0000106 extension extension decreased length , abnormal
extension increased thickness , abnormal
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 ZFA:0000109 forebrain forebrain apoptotic , abnormal
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 ZFA:0000128 midbrain midbrain apoptotic , abnormal
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 ZFA:0000135 notochord notochord undulate , abnormal
notochord decreased length , abnormal
notochord increased width , abnormal
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 ZFA:0000155 somite somite malformed , abnormal
somite increased width , abnormal
somite condensed , abnormal
somite deformed , abnormal
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 ZFA:0000217 inner ear inner ear increased size , abnormal
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 ZFA:0000445 optic tectum optic tectum apoptotic , abnormal
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 ZFA:0000559 otolith organ otolith organ has fewer parts of type otolith , abnormal
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 ZFA:0001094 whole organism whole organism apoptotic , abnormal
whole organism decreased length , abnormal
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 ZFA:0001114 head head opaque , abnormal
head decreased size , abnormal
head mislocalised posteriorly , abnormal
head position , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region morphology , abnormal
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 ZFA:0001462 somite border somite border hypoplastic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018285 pdpk1b / 3-phosphoinositide dependent protein kinase 1b / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*  / reaction / complex
 ENSDARG00000026294 erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction
 ENSDARG00000009796 klc1a / kinesin light chain 1a / KLC1* / Q07866* / AL139300.1* / kinesin light chain 1* / kinesin light chain 1 isoform 1G *  / reaction / complex
 ENSDARG00000004218 rnd1b / Rho family GTPase 1b / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *  / reaction
 ENSDARG00000032802 ktn1 / kinectin 1 / Q86UP2*  / complex / reaction
 ENSDARG00000062187 kif14 / kinesin family member 14 / L0N7N1* / Q15058* / Kinesin-like protein KIF14 *  / reaction / complex
 ENSDARG00000089444 omgb / oligodendrocyte myelin glycoprotein b / OMG* / P23515* / oligodendrocyte myelin glycoprotein*  / complex / reaction
 ENSDARG00000101983 pkn2 / protein kinase N2 / Q16513*  / reaction / complex
 ENSDARG00000037746 actb1 / Q7ZVI7 / actin, beta 1 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / complex / reaction
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / complex / reaction
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / reaction
 ENSDARG00000103542 O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*  / reaction
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / complex / reaction
 ENSDARG00000035899 Q66HV9 / lingo1b / leucine rich repeat and Ig domain containing 1b / Q9D1T0* / LINGO1* / Q96FE5* / leucine rich repeat and Ig domain containing 1* / Leucine-rich repeat and immunoglobulin-l...  / reaction / complex
 ENSDARG00000101293 zgc:153916 / PKN2 (1 of many) / PKN2* / Q16513* / protein kinase N2*  / complex / reaction
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / reaction
 ENSDARG00000104023 mag / myelin associated glycoprotein / P20917* / P20916* / AC011452.1* / Mus musculus myelin-associated glycoprotein (Mag), transcript variant 5, mRNA.*  / reaction / complex
 ENSDARG00000034165 lingo1a / leucine rich repeat and Ig domain containing 1a / Q9D1T0* / LINGO1* / Q96FE5* / leucine rich repeat and Ig domain containing 1* / Leucine-rich repeat and immunoglobulin-like domai...  / reaction / complex
 ENSDARG00000037870 actb2 / Q7ZVF9 / actin, beta 2 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / complex / reaction
 ENSDARG00000088708 ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSDARG00000089223 ngfrb / nerve growth factor receptor b / NGFR* / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSDARG00000030547 rnd1a / Rho family GTPase 1a / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *  / reaction
 ENSDARG00000022895 mcf2a / MCF.2 cell line derived transforming sequence a / MCF2* / P10911* / MCF.2 cell line derived transforming sequence*  / reaction
 ENSDARG00000035650 evla / Enah/Vasp-like a / EVL* / Q9UI08* / P70429* / Enah/Vasp-like* / Ena/VASP-like protein *  / reaction / complex
 ENSDARG00000030532 arhgef12a / Rho guanine nucleotide exchange factor (GEF) 12a / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12*  / reaction
 ENSDARG00000062577 arhgap35a / Rho GTPase activating protein 35a / Q91YM2* / Q9NRY4* / ARHGAP35* / Rho GTPase activating protein 35*  / complex / reaction
 ENSDARG00000060415 arhgef28 / Rho guanine nucleotide exchange factor (GEF) 28 / Q8N1W1* / Rho guanine nucleotide exchange factor 28*  / reaction
 ENSDARG00000077410 myo9b / myosin IXb / Q13459*  / reaction
 ENSDARG00000060297 arhgap35b / Rho GTPase activating protein 35b / Q91YM2* / Q9NRY4* / ARHGAP35* / Rho GTPase activating protein 35*  / complex / reaction
 ENSDARG00000031345 si:dkey-40c11.1 / RTKN* / Q8C6B2* / Q9BST9* / rhotekin*  / complex
 ENSDARG00000059177 tax1bp3 / Tax1 (human T-cell leukemia virus type I) binding protein 3 / O14907* / Q9DBG9* / Tax1 binding protein 3*  / reaction / complex
 ENSDARG00000075121 hbegfa / heparin-binding EGF-like growth factor a / HBEGF* / Q06186* / Q99075* / heparin binding EGF like growth factor* / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like...  / reaction / complex
 ENSDARG00000075962 vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*  / reaction
 ENSDARG00000076179 ngef / neuronal guanine nucleotide exchange factor / Q8CHT1* / Q8N5V2* / Ephexin-1 *  / reaction
 ENSDARG00000044718 vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*  / reaction
 ENSDARG00000078313 MYO9B / si:zfos-588f8.1 / Q13459* / myosin IXB*  / reaction
 ENSDARG00000098112 btc / betacellulin, epidermal growth factor family member / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / reaction / complex
 ENSDARG00000098936 kif5aa / kinesin family member 5A, a / KIF5A* / Q12840* / kinesin family member 5A*  / complex / reaction
 ENSDARG00000100918 prc1a / protein regulator of cytokinesis 1a / PRC1* / O43663* / protein regulator of cytokinesis 1*  / reaction / complex
 ENSDARG00000100913 arhgef12b / Rho guanine nucleotide exchange factor (GEF) 12b / Q8R4H2* / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12* / Mus musculus Rho guanine nucleotide exchange fact...  / reaction
 ENSDARG00000058993 rock1 / Rho-associated, coiled-coil containing protein kinase 1 / Q13464*  / complex / reaction






 

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