ENSDARG00000035899


Danio rerio

Features
Gene ID: ENSDARG00000035899
  
Biological name :lingo1b
  
Synonyms : leucine rich repeat and Ig domain containing 1b / lingo1b / Q66HV9
  
Possible biological names infered from orthology : leucine rich repeat and Ig domain containing 1 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 / LINGO1 / Q96FE5 / Q9D1T0
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 48460239
Gene end: 48484917
  
Corresponding Affymetrix probe sets: Dr.12903.1.A1_at (Zebrafish Array)   NM_001004576_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000052112
NCBI entrez gene - 447837     See in Manteia.
RefSeq - NM_001004576
RefSeq Peptide - NP_001004576
swissprot - Q66HV9
ZFIN ID - ZDB-GENE-040912-136
Ensembl - ENSDARG00000035899
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LINGO1ENSGALG00000002708Gallus gallus
 LINGO1ENSG00000169783Homo sapiens
 Lingo1ENSMUSG00000049556Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lingo1a / leucine rich repeat and Ig domain containing 1a / Q9D1T0* / LINGO1* / Q96FE5* / leucine rich repeat and Ig domain containing 1* / Leucine-rich repeat and immunoglobulin-like domai...ENSDARG0000003416578
lingo2a / leucine rich repeat and Ig domain containing 2a / LINGO2* / Q7L985* / Q3URE9* / leucine rich repeat and Ig domain containing 2*ENSDARG0000007453550
CABZ01060891.1 / LINGO3* / P0C6S8* / leucine rich repeat and Ig domain containing 3*ENSDARG0000006781548
lingo4b / leucine rich repeat and Ig domain containing 4b / LINGO4* / Q6UY18* / leucine rich repeat and Ig domain containing 4*ENSDARG0000007852747
lingo3a / leucine rich repeat and Ig domain containing 3a / Q6GQU6* / LINGO3* / P0C6S8* / leucine rich repeat and Ig domain containing 3* / Leucine-rich repeat and immunoglobulin-like domai...ENSDARG0000006197047
lingo4a / leucine rich repeat and Ig domain containing 4a / LINGO4* / Q6UY18* / leucine rich repeat and Ig domain containing 4*ENSDARG0000009490844
lingo2b / leucine rich repeat and Ig domain containing 2b / LINGO2* / Q7L985* / Q3URE9* / leucine rich repeat and Ig domain containing 2*ENSDARG0000006997042
lrrc4c / leucine rich repeat containing 4C / Q9HCJ2*ENSDARG0000011341125
lrrn1 / leucine rich repeat neuronal 1 / Q61809* / Q6UXK5* / Leucine-rich repeat neuronal protein 1 *ENSDARG0000006011525
lrrc4ba / leucine rich repeat containing 4Ba / Q9NT99* / LRRC4B* / P0C192* / leucine rich repeat containing 4B* / Leucine-rich repeat-containing protein 4B *ENSDARG0000000459724
si:dkey-6l15.1 / LRRC4C (1 of many) / LRRC4C* / Q8C031* / Q9HCJ2* / leucine rich repeat containing 4C* / Leucine-rich repeat-containing protein 4C *ENSDARG0000001673924
si:ch211-180f4.1ENSDARG0000007711224
lrrc4bb / leucine rich repeat containing 4Bb / Q9NT99* / LRRC4B* / P0C192* / leucine rich repeat containing 4B* / Leucine-rich repeat-containing protein 4B *ENSDARG0000001479224
lrrc4.2 / leucine rich repeat containing 4.2 / LRRC4* / Q99PH1* / Q9HBW1* / leucine rich repeat containing 4* / Leucine-rich repeat-containing protein 4 *ENSDARG0000000302023
lrrn3a / leucine rich repeat neuronal 3a / LRRN3* / Q8CBC6* / Q9H3W5* / leucine rich repeat neuronal 3* / Leucine-rich repeat neuronal protein 3 *ENSDARG0000007756922
lrfn4b / leucine rich repeat and fibronectin type III domain containing 4b / LRFN4* / Q6PJG9* / Q80XU8* / leucine rich repeat and fibronectin type III domain containing 4* / Leucine-rich re...ENSDARG0000007807822
lrrc4.1 / leucine rich repeat containing 4.1 / LRRC4* / Q99PH1* / Q9HBW1* / leucine rich repeat containing 4* / Leucine-rich repeat-containing protein 4 *ENSDARG0000006940222
LRFN3 / zmp:0000001073 / Q8BLY3* / Q9BTN0* / leucine rich repeat and fibronectin type III domain containing 3* / Leucine-rich repeat and fibronectin type-III domain-containing protein 3 *ENSDARG0000003950021
lrrn3b / leucine rich repeat neuronal 3b / LRRN3* / Q9H3W5* / leucine rich repeat neuronal 3*ENSDARG0000010270221
lrfn5b / leucine rich repeat and fibronectin type III domain containing 5b / LRFN5* / Q8BXA0* / Q96NI6* / leucine rich repeat and fibronectin type III domain containing 5* / Leucine-rich re...ENSDARG0000007939621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007409 axonogenesis IBA
 biological_processGO:0042552 myelination IMP
 biological_processGO:0048666 neuron development IMP
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord curved , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0009076 oligodendrocyte oligodendrocyte cell migration decreased process quality , abnormal
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 ZFA:0009149 Mauthner neuron Mauthner neuron decreased diameter , abnormal
Mauthner neuron myelination increased process quality , abnormal
Mauthner neuron myelin sheath increased thickness , abnormal
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 ZFA:0009248 neuron neuron myelination increased process quality , abnormal
neuron myelin sheath increased thickness , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / reaction / complex
 ENSDARG00000089444 omgb / oligodendrocyte myelin glycoprotein b / OMG* / P23515* / oligodendrocyte myelin glycoprotein*  / complex / reaction
 ENSDARG00000104023 mag / myelin associated glycoprotein / P20917* / P20916* / AC011452.1* / Mus musculus myelin-associated glycoprotein (Mag), transcript variant 5, mRNA.*  / reaction / complex
 ENSDARG00000088708 ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor*  / reaction / complex
 ENSDARG00000089223 ngfrb / nerve growth factor receptor b / NGFR* / P08138* / nerve growth factor receptor*  / reaction / complex






 

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