ENSG00000169783


Homo sapiens

Features
Gene ID: ENSG00000169783
  
Biological name :LINGO1
  
Synonyms : leucine rich repeat and Ig domain containing 1 / LINGO1 / Q96FE5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q24.3
Gene start: 77613027
Gene end: 77820900
  
Corresponding Affymetrix probe sets: 227933_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457101
Ensembl peptide - ENSP00000455605
Ensembl peptide - ENSP00000456516
Ensembl peptide - ENSP00000347451
Ensembl peptide - ENSP00000453780
Ensembl peptide - ENSP00000453853
Ensembl peptide - ENSP00000454051
Ensembl peptide - ENSP00000454245
Ensembl peptide - ENSP00000454465
Ensembl peptide - ENSP00000454577
Ensembl peptide - ENSP00000454687
NCBI entrez gene - 84894     See in Manteia.
OMIM - 609791
RefSeq - NM_001301199
RefSeq - NM_001301186
RefSeq - NM_001301187
RefSeq - NM_001301189
RefSeq - NM_001301191
RefSeq - NM_001301192
RefSeq - NM_001301194
RefSeq - NM_001301195
RefSeq - NM_001301197
RefSeq - NM_001301198
RefSeq - NM_001301200
RefSeq - NM_032808
RefSeq - XM_011522118
RefSeq - XM_017022682
RefSeq Peptide - NP_001288127
RefSeq Peptide - NP_001288128
RefSeq Peptide - NP_001288129
RefSeq Peptide - NP_116197
RefSeq Peptide - NP_001288115
RefSeq Peptide - NP_001288116
RefSeq Peptide - NP_001288118
RefSeq Peptide - NP_001288120
RefSeq Peptide - NP_001288121
RefSeq Peptide - NP_001288123
RefSeq Peptide - NP_001288124
RefSeq Peptide - NP_001288126
swissprot - H0YMX3
swissprot - H3BN48
swissprot - Q96FE5
swissprot - H3BQ49
swissprot - H3BS32
swissprot - H0YNK7
swissprot - H3BM59
swissprot - H3BMN3
swissprot - H3BMW2
Ensembl - ENSG00000169783
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lingo1aENSDARG00000034165Danio rerio
 Q66HV9ENSDARG00000035899Danio rerio
 LINGO1ENSGALG00000002708Gallus gallus
 Lingo1ENSMUSG00000049556Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LINGO2 / Q7L985 / leucine rich repeat and Ig domain containing 2ENSG0000017448259
LINGO3 / P0C6S8 / leucine rich repeat and Ig domain containing 3ENSG0000022000852
LINGO4 / Q6UY18 / leucine rich repeat and Ig domain containing 4ENSG0000021317142
LRRC4C / Q9HCJ2 / leucine rich repeat containing 4CENSG0000014894826
LRRC4B / Q9NT99 / leucine rich repeat containing 4BENSG0000013140925
LRRN3 / Q9H3W5 / leucine rich repeat neuronal 3ENSG0000017311425
LRRN1 / Q6UXK5 / leucine rich repeat neuronal 1ENSG0000017592825
LRRC4 / Q9HBW1 / leucine rich repeat containing 4ENSG0000012859424
LRRN2 / O75325 / leucine rich repeat neuronal 2ENSG0000017038224
LRFN5 / Q96NI6 / leucine rich repeat and fibronectin type III domain containing 5ENSG0000016537923
LRFN2 / Q9ULH4 / leucine rich repeat and fibronectin type III domain containing 2ENSG0000015656422
LRFN1 / Q9P244 / leucine rich repeat and fibronectin type III domain containing 1ENSG0000012801122
LRFN3 / Q9BTN0 / leucine rich repeat and fibronectin type III domain containing 3ENSG0000012624321
LRFN4 / Q6PJG9 / leucine rich repeat and fibronectin type III domain containing 4ENSG0000017362121


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR026906  Leucine rich repeat 5
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007409 axonogenesis IBA
 biological_processGO:0050771 negative regulation of axonogenesis TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000040608 RTN4R / Q9BZR6 / reticulon 4 receptor  / reaction / complex
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / reaction / complex
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction / complex
 ENSG00000141522 P52565 / ARHGDIA / Rho GDP dissociation inhibitor alpha  / complex / reaction
 ENSG00000126861 OMG / P23515 / oligodendrocyte myelin glycoprotein  / reaction / complex
 ENSG00000115310 RTN4 / Q9NQC3 / reticulon 4  / reaction / complex
 ENSG00000105695 MAG / P20916 / myelin associated glycoprotein  / reaction / complex






 

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