ENSG00000128594


Homo sapiens

Features
Gene ID: ENSG00000128594
  
Biological name :LRRC4
  
Synonyms : leucine rich repeat containing 4 / LRRC4 / Q9HBW1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q32.1
Gene start: 128027071
Gene end: 128032107
  
Corresponding Affymetrix probe sets: 223552_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000249363
Ensembl peptide - ENSP00000418254
Ensembl peptide - ENSP00000418093
Ensembl peptide - ENSP00000417795
NCBI entrez gene - 64101     See in Manteia.
OMIM - 610486
RefSeq - NM_022143
RefSeq - XM_017012505
RefSeq - XM_011516461
RefSeq Peptide - NP_071426
swissprot - C9JA92
swissprot - Q9HBW1
swissprot - C9J7K7
swissprot - C9J7V8
Ensembl - ENSG00000128594
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrc4.1ENSDARG00000069402Danio rerio
 lrrc4.2ENSDARG00000003020Danio rerio
 Lrrc4ENSMUSG00000049939Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRC4B / Q9NT99 / leucine rich repeat containing 4BENSG0000013140957
LRRC4C / Q9HCJ2 / leucine rich repeat containing 4CENSG0000014894855
LINGO4 / Q6UY18 / leucine rich repeat and Ig domain containing 4ENSG0000021317124
LINGO1 / Q96FE5 / leucine rich repeat and Ig domain containing 1ENSG0000016978323
LINGO2 / Q7L985 / leucine rich repeat and Ig domain containing 2ENSG0000017448223
LINGO3 / P0C6S8 / leucine rich repeat and Ig domain containing 3ENSG0000022000823
LRRN2 / O75325 / leucine rich repeat neuronal 2ENSG0000017038222
LRRN3 / Q9H3W5 / leucine rich repeat neuronal 3ENSG0000017311421
LRRN1 / Q6UXK5 / leucine rich repeat neuronal 1ENSG0000017592821
LRFN1 / Q9P244 / leucine rich repeat and fibronectin type III domain containing 1ENSG0000012801120
LRFN2 / Q9ULH4 / leucine rich repeat and fibronectin type III domain containing 2ENSG0000015656419
LRFN5 / Q96NI6 / leucine rich repeat and fibronectin type III domain containing 5ENSG0000016537919
LRFN4 / Q6PJG9 / leucine rich repeat and fibronectin type III domain containing 4ENSG0000017362118
LRFN3 / Q9BTN0 / leucine rich repeat and fibronectin type III domain containing 3ENSG0000012624318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR026882  Leucine-rich repeat-containing protein 4
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0050807 regulation of synapse organization IEA
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0097119 postsynaptic density protein 95 clustering IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044309 neuron spine IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0060076 excitatory synapse IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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