ENSG00000173621


Homo sapiens

Features
Gene ID: ENSG00000173621
  
Biological name :LRFN4
  
Synonyms : leucine rich repeat and fibronectin type III domain containing 4 / LRFN4 / Q6PJG9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.2
Gene start: 66856647
Gene end: 66860475
  
Corresponding Affymetrix probe sets: 219491_at (Human Genome U133 Plus 2.0 Array)   238092_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000312535
Ensembl peptide - ENSP00000377524
NCBI entrez gene - 78999     See in Manteia.
OMIM - 612810
RefSeq - NM_024036
RefSeq - XM_005274239
RefSeq Peptide - NP_076941
swissprot - E7ENX6
swissprot - A0A024R5I6
swissprot - Q6PJG9
Ensembl - ENSG00000173621
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrfn4aENSDARG00000055132Danio rerio
 lrfn4bENSDARG00000078078Danio rerio
 Lrfn4ENSMUSG00000045045Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRFN2 / Q9ULH4 / leucine rich repeat and fibronectin type III domain containing 2ENSG0000015656455
LRFN1 / Q9P244 / leucine rich repeat and fibronectin type III domain containing 1ENSG0000012801150
LRFN3 / Q9BTN0 / leucine rich repeat and fibronectin type III domain containing 3ENSG0000012624349
LRFN5 / Q96NI6 / leucine rich repeat and fibronectin type III domain containing 5ENSG0000016537946
LINGO3 / P0C6S8 / leucine rich repeat and Ig domain containing 3ENSG0000022000823
LRRN2 / O75325 / leucine rich repeat neuronal 2ENSG0000017038223
LINGO2 / Q7L985 / leucine rich repeat and Ig domain containing 2ENSG0000017448222
LRRN1 / Q6UXK5 / leucine rich repeat neuronal 1ENSG0000017592821
LRRC4B / Q9NT99 / leucine rich repeat containing 4BENSG0000013140921
LRRN3 / Q9H3W5 / leucine rich repeat neuronal 3ENSG0000017311420
LINGO1 / Q96FE5 / leucine rich repeat and Ig domain containing 1ENSG0000016978320
LINGO4 / Q6UY18 / leucine rich repeat and Ig domain containing 4ENSG0000021317120
LRRC4C / Q9HCJ2 / leucine rich repeat containing 4CENSG0000014894819
LRRC4 / Q9HBW1 / leucine rich repeat containing 4ENSG0000012859418


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007409 axonogenesis IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000156564 LRFN2 / Q9ULH4 / leucine rich repeat and fibronectin type III domain containing 2  / complex / reaction
 ENSG00000105426 PTPRS / Q13332 / protein tyrosine phosphatase, receptor type S  / reaction / complex
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / reaction / complex
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / reaction / complex
 ENSG00000075711 DLG1 / Q12959 / discs large MAGUK scaffold protein 1  / complex / reaction
 ENSG00000153707 PTPRD / P23468 / protein tyrosine phosphatase, receptor type D  / reaction / complex
 ENSG00000173621 LRFN4 / Q6PJG9 / leucine rich repeat and fibronectin type III domain containing 4  / complex / reaction
 ENSG00000142949 PTPRF / P10586 / protein tyrosine phosphatase, receptor type F  / reaction / complex
 ENSG00000128011 LRFN1 / Q9P244 / leucine rich repeat and fibronectin type III domain containing 1  / complex / reaction






 

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