ENSMUSG00000045045


Mus musculus

Features
Gene ID: ENSMUSG00000045045
  
Biological name :Lrfn4
  
Synonyms : Leucine-rich repeat and fibronectin type-III domain-containing protein 4 / Lrfn4 / Q80XU8
  
Possible biological names infered from orthology : leucine rich repeat and fibronectin type III domain containing 4 / Q6PJG9
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 4611785
Gene end: 4615667
  
Corresponding Affymetrix probe sets: 10464775 (MoGene1.0st)   1454700_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050039
Ensembl peptide - ENSMUSP00000109453
NCBI entrez gene - 225875     See in Manteia.
MGI - MGI:2385612
RefSeq - XM_017318142
RefSeq - NM_153388
RefSeq Peptide - NP_700437
swissprot - Q80XU8
Ensembl - ENSMUSG00000045045
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrfn4aENSDARG00000055132Danio rerio
 lrfn4bENSDARG00000078078Danio rerio
 LRFN4ENSG00000173621Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrfn2 / Q80TG9 / Leucine-rich repeat and fibronectin type-III domain-containing protein 2 / Q9ULH4* / leucine rich repeat and fibronectin type III domain containing 2*ENSMUSG0000004049054
Lrfn1 / Q2WF71 / Leucine-rich repeat and fibronectin type III domain-containing protein 1 / Q9P244* / leucine rich repeat and fibronectin type III domain containing 1*ENSMUSG0000003060049
Lrfn3 / Q8BLY3 / Leucine-rich repeat and fibronectin type-III domain-containing protein 3 / Q9BTN0* / leucine rich repeat and fibronectin type III domain containing 3*ENSMUSG0000003695748
Lrfn5 / Q8BXA0 / Leucine-rich repeat and fibronectin type-III domain-containing protein 5 / Q96NI6* / leucine rich repeat and fibronectin type III domain containing 5*ENSMUSG0000003565347
Lrrn2 / leucine rich repeat protein 2, neuronal / O75325* / leucine rich repeat neuronal 2*ENSMUSG0000002644323
Lingo2 / Q3URE9 / leucine rich repeat and Ig domain containing 2 / Q7L985*ENSMUSG0000004508322
Lrrc4b / P0C192 / Leucine-rich repeat-containing protein 4B / Q9NT99* / leucine rich repeat containing 4B*ENSMUSG0000004708521
Lingo3 / Q6GQU6 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 / P0C6S8* / leucine rich repeat and Ig domain containing 3*ENSMUSG0000005106721
Lrrn1 / Q61809 / Leucine-rich repeat neuronal protein 1 / Q6UXK5* / leucine rich repeat neuronal 1*ENSMUSG0000003464821
Lrrn3 / Q8CBC6 / Leucine-rich repeat neuronal protein 3 / Q9H3W5* / leucine rich repeat neuronal 3*ENSMUSG0000003629521
Lingo1 / Q9D1T0 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 / Q96FE5* / leucine rich repeat and Ig domain containing 1*ENSMUSG0000004955620
Lingo4 / leucine rich repeat and Ig domain containing 4 / Q6UY18*ENSMUSG0000004450519
Lrrc4c / Q8C031 / Leucine-rich repeat-containing protein 4C / Q9HCJ2* / leucine rich repeat containing 4C*ENSMUSG0000005058718
Lrrc4 / Q99PH1 / Leucine-rich repeat-containing protein 4 / Q9HBW1* / leucine rich repeat containing 4*ENSMUSG0000004993918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007409 axonogenesis IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Juptm1.1Chen/Juptm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lrfn3tm1(KOMP)Vlcg/Lrfn3tm1(KOMP)Vlcg,Lrfn4tm1(KOMP)Vlcg/Lrfn4tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juptm1.1Chen/Juptm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008035 behavioral arrest "locomotor activity is interrupted by sudden periods of no movement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juptm1.1Chen/Juptm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Lrfn3tm1(KOMP)Vlcg/Lrfn3tm1(KOMP)Vlcg,Lrfn4tm1(KOMP)Vlcg/Lrfn4tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0020357 abnormal excitatory synapse morphology "any structural anomaly of a synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell" [GO:0060076]
Show

Allelic Composition: Juptm1.1Chen/Juptm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000013236 Ptprs / B0V2N1 / Receptor-type tyrosine-protein phosphatase S / Q13332* / protein tyrosine phosphatase, receptor type S*  / reaction / complex
 ENSMUSG00000033295 Ptprf / A2A8L5 / Receptor-type tyrosine-protein phosphatase F / P10586* / protein tyrosine phosphatase, receptor type F*  / complex / reaction
 ENSMUSG00000028399 Ptprd / Q64487 / protein tyrosine phosphatase, receptor type, D / P23468*  / complex / reaction
 ENSMUSG00000040490 Lrfn2 / Q80TG9 / Leucine-rich repeat and fibronectin type-III domain-containing protein 2 / Q9ULH4* / leucine rich repeat and fibronectin type III domain containing 2*  / reaction / complex
 ENSMUSG00000030600 Lrfn1 / Q2WF71 / Leucine-rich repeat and fibronectin type III domain-containing protein 1 / Q9P244* / leucine rich repeat and fibronectin type III domain containing 1*  / reaction / complex
 ENSMUSG00000022770 Dlg1 / Q811D0 / Disks large homolog 1 / Q12959* / discs large MAGUK scaffold protein 1*  / complex / reaction
 ENSMUSG00000000881 Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*  / complex / reaction
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / reaction / complex
 ENSMUSG00000045045 Lrfn4 / Q80XU8 / Leucine-rich repeat and fibronectin type-III domain-containing protein 4 / Q6PJG9* / leucine rich repeat and fibronectin type III domain containing 4*  / reaction / complex






 

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