ENSMUSG00000033295


Mus musculus

Features
Gene ID: ENSMUSG00000033295
  
Biological name :Ptprf
  
Synonyms : A2A8L5 / Ptprf / Receptor-type tyrosine-protein phosphatase F
  
Possible biological names infered from orthology : P10586 / protein tyrosine phosphatase, receptor type F
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.1
Gene start: 118208213
Gene end: 118291405
  
Corresponding Affymetrix probe sets: 10515613 (MoGene1.0st)   1420841_at (Mouse Genome 430 2.0 Array)   1420842_at (Mouse Genome 430 2.0 Array)   1420843_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152568
Ensembl peptide - ENSMUSP00000039368
Ensembl peptide - ENSMUSP00000117313
Ensembl peptide - ENSMUSP00000119954
NCBI entrez gene - 19268     See in Manteia.
MGI - MGI:102695
RefSeq - XM_006502876
RefSeq - XM_006502870
RefSeq - XM_006502871
RefSeq - XM_006502872
RefSeq - XM_006502874
RefSeq - XM_006502875
RefSeq - NM_011213
RefSeq - XM_006502864
RefSeq - XM_006502865
RefSeq - XM_006502866
RefSeq - XM_006502867
RefSeq - XM_006502868
RefSeq - XM_006502869
RefSeq Peptide - NP_035343
swissprot - F6S1X8
swissprot - F6Y3V0
swissprot - A2A8L5
swissprot - A0A1Y7VNR5
Ensembl - ENSMUSG00000033295
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A4IFW2ENSDARG00000005754Danio rerio
 ptprfaENSDARG00000103479Danio rerio
 PTPRFENSGALG00000010053Gallus gallus
 PTPRFENSG00000142949Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptprs / B0V2N1 / Receptor-type tyrosine-protein phosphatase S / Q13332* / protein tyrosine phosphatase, receptor type S*ENSMUSG0000001323667
Ptprd / Q64487 / protein tyrosine phosphatase, receptor type, D / P23468*ENSMUSG0000002839957
B9EKR1 / Ptprz1 / protein tyrosine phosphatase, receptor type Z, polypeptide 1 / P23471* / protein tyrosine phosphatase, receptor type Z1*ENSMUSG0000006874822
Ptprk / P35822 / protein tyrosine phosphatase, receptor type, K / Q15262*ENSMUSG0000001988921
Ptprm / P28828 / protein tyrosine phosphatase, receptor type, M / P28827*ENSMUSG0000003327821
Ptprt / Q99M80 / Receptor-type tyrosine-protein phosphatase T / O14522* / protein tyrosine phosphatase, receptor type T*ENSMUSG0000005314120
Ptpru / B1AUH1 / protein tyrosine phosphatase, receptor type, U / Q92729*ENSMUSG0000002890919
Ptprg / receptor-type tyrosine-protein phosphatase gamma isoform 2 / P23470* / protein tyrosine phosphatase, receptor type G*ENSMUSG0000002174519
Ptpra / P18052 / protein tyrosine phosphatase, receptor type, A / P18433*ENSMUSG0000002730318
Ptprc / protein tyrosine phosphatase, receptor type, CENSMUSG0000002639518
Ptpre / P49446 / Receptor-type tyrosine-protein phosphatase epsilon / P23469* / protein tyrosine phosphatase, receptor type E*ENSMUSG0000004183617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010975 regulation of neuron projection development IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0031102 neuron projection regeneration IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0048679 regulation of axon regeneration IMP
 biological_processGO:1900121 negative regulation of receptor binding IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity ISO
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0035373 chondroitin sulfate proteoglycan binding IPI


Pathways (from Reactome)
Pathway description
Receptor-type tyrosine-protein phosphatases
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mecp2tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0000536 hydroureter "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0003586 ureter dilation "abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0003672 abnormal ureter development "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0003838 abnormal milk ejection "impaired milk ejection reflex in response to suckling during lactation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:36926]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0004017 duplex kidney "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0004220 abnormal peripheral nervous system regeneration "changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mecp2tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0008512 disorganized retinal inner nuclear layer "derangement of the normal pattern of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011493 double ureter "two ureters open separately into the renal pelvis superiorly and drain separately into the urinary bladder or genital tract; if two ureteral buds arise from the Wolffian duct, a duplex kidney with complete ureteral duplication ensues" [http://emedicine.medscape.com/article/378075-overview, MGI:anna]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0011767 ureterocele "saccular dilation of the terminal portion of the ureter that protrudes into the lumen of the urinary bladder, probably due to a congenital stenosis of the ureteric orifice meatus; most often associated with a duplicated collection system, where two ureters drain their respective kidney instead of one" [MGI:anna]
Show

Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0012538 persistent hyaloid artery "incomplete regression of the hyaloid artery, usually accompanied by persistence of the hyperplastic primary vitreous; small remnants of the artery may remain with free remnants sometimes seen as floating material (aka muscae volitantes); an anterior remnant of the hyaloid artery can be seen as Mittendorf s dot, a small pinpoint-like scar on the posterior surface of the lens; a posterior remnant may be seen where the artery left the optic disc, and is known as Bergmeister s papilla" [MGI:anna]
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Allelic Composition: Ptprftm1Wjh/Ptprftm1Wjh,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

 MP:0030012 impaired central nervous system regeneration "reduced or delayed ability to regenerate healthy central nervous system tissue following injury or disease" [MGI:anna]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003863 P60469 / Ppfia3 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 / O75145* / PTPRF interacting protein alpha 3*  / complex / reaction
 ENSMUSG00000016487 Q8C8U0 / Ppfibp1 / PTPRF interacting protein, binding protein 1 (liprin beta 1) / Q86W92* / PPFIA binding protein 1*  / reaction / complex
 ENSMUSG00000036528 O35711 / Ppfibp2 / PTPRF interacting protein, binding protein 2 (liprin beta 2) / Q8ND30* / PPFIA binding protein 2*  / complex / reaction
 ENSMUSG00000053825 Ppfia2 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 / O75334* / PTPRF interacting protein alpha 2*  / reaction / complex
 ENSMUSG00000045045 Lrfn4 / Q80XU8 / Leucine-rich repeat and fibronectin type-III domain-containing protein 4 / Q6PJG9* / leucine rich repeat and fibronectin type III domain containing 4*  / reaction / complex
 ENSMUSG00000047085 Lrrc4b / P0C192 / Leucine-rich repeat-containing protein 4B / Q9NT99* / leucine rich repeat containing 4B*  / reaction / complex
 ENSMUSG00000037519 Ppfia1 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 / Q13136* / PTPRF interacting protein alpha 1*  / complex / reaction
 ENSMUSG00000026458 Ppfia4 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 / O75335* / PTPRF interacting protein alpha 4*  / complex / reaction






 

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