ENSMUSG00000068748


Mus musculus

Features
Gene ID: ENSMUSG00000068748
  
Biological name :Ptprz1
  
Synonyms : B9EKR1 / protein tyrosine phosphatase, receptor type Z, polypeptide 1 / Ptprz1
  
Possible biological names infered from orthology : P23471 / protein tyrosine phosphatase, receptor type Z1
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A3.1
Gene start: 22875502
Gene end: 23052916
  
Corresponding Affymetrix probe sets: 10536667 (MoGene1.0st)   1418690_at (Mouse Genome 430 2.0 Array)   1427019_at (Mouse Genome 430 2.0 Array)   1452284_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143902
Ensembl peptide - ENSMUSP00000144605
Ensembl peptide - ENSMUSP00000088056
NCBI entrez gene - 19283     See in Manteia.
MGI - MGI:97816
RefSeq - XM_006505018
RefSeq - XM_006505012
RefSeq - XM_006505013
RefSeq - XM_006505014
RefSeq - XM_006505015
RefSeq - XM_006505017
RefSeq - NM_001081306
RefSeq - NM_001311064
RefSeq Peptide - NP_001297993
RefSeq Peptide - NP_001074775
swissprot - B9EKR1
swissprot - B2RXS8
swissprot - A0A0J9YVD2
Ensembl - ENSMUSG00000068748
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprz1aENSDARG00000051814Danio rerio
 ptprz1bENSDARG00000020871Danio rerio
 PTPRZ1ENSGALG00000040114Gallus gallus
 P23471ENSG00000106278Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptprg / receptor-type tyrosine-protein phosphatase gamma isoform 2 / P23470* / protein tyrosine phosphatase, receptor type G*ENSMUSG0000002174530
Ptprs / B0V2N1 / Receptor-type tyrosine-protein phosphatase S / Q13332* / protein tyrosine phosphatase, receptor type S*ENSMUSG0000001323618
Ptprf / A2A8L5 / Receptor-type tyrosine-protein phosphatase F / P10586* / protein tyrosine phosphatase, receptor type F*ENSMUSG0000003329518
Ptprd / Q64487 / protein tyrosine phosphatase, receptor type, D / P23468*ENSMUSG0000002839916
Ptprt / Q99M80 / Receptor-type tyrosine-protein phosphatase T / O14522* / protein tyrosine phosphatase, receptor type T*ENSMUSG0000005314114
Ptprm / P28828 / protein tyrosine phosphatase, receptor type, M / P28827*ENSMUSG0000003327814
Ptprk / P35822 / protein tyrosine phosphatase, receptor type, K / Q15262*ENSMUSG0000001988913
Ptpru / B1AUH1 / protein tyrosine phosphatase, receptor type, U / Q92729*ENSMUSG0000002890912
Ptprc / protein tyrosine phosphatase, receptor type, CENSMUSG0000002639511
Ptpra / P18052 / protein tyrosine phosphatase, receptor type, A / P18433*ENSMUSG0000002730311
Ptpre / P49446 / Receptor-type tyrosine-protein phosphatase epsilon / P23469* / protein tyrosine phosphatase, receptor type E*ENSMUSG0000004183610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001148  Alpha carbonic anhydrase domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR023561  Carbonic anhydrase, alpha-class
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily
 IPR036398  Alpha carbonic anhydrase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007409 axonogenesis IDA
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation ISS
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0070445 regulation of oligodendrocyte progenitor proliferation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane ISS
 cellular_componentGO:0072534 perineuronal net IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Adra1atm1Pcs/Adra1a+
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031750 Il34 / Q8R1R4 / Interleukin-34 / Q6ZMJ4*  / reaction / complex






 

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