ENSMUSG00000028399


Mus musculus

Features
Gene ID: ENSMUSG00000028399
  
Biological name :Ptprd
  
Synonyms : protein tyrosine phosphatase, receptor type, D / Ptprd / Q64487
  
Possible biological names infered from orthology : P23468
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C3
Gene start: 75941238
Gene end: 78211961
  
Corresponding Affymetrix probe sets: 10513957 (MoGene1.0st)   1424886_at (Mouse Genome 430 2.0 Array)   1429052_at (Mouse Genome 430 2.0 Array)   1435537_at (Mouse Genome 430 2.0 Array)   1443860_at (Mouse Genome 430 2.0 Array)   1444492_at (Mouse Genome 430 2.0 Array)   1445767_at (Mouse Genome 430 2.0 Array)   1459173_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133973
Ensembl peptide - ENSMUSP00000133832
Ensembl peptide - ENSMUSP00000134190
Ensembl peptide - ENSMUSP00000148560
Ensembl peptide - ENSMUSP00000134229
Ensembl peptide - ENSMUSP00000058466
Ensembl peptide - ENSMUSP00000095614
Ensembl peptide - ENSMUSP00000099898
Ensembl peptide - ENSMUSP00000102910
Ensembl peptide - ENSMUSP00000133328
Ensembl peptide - ENSMUSP00000133468
Ensembl peptide - ENSMUSP00000133562
Ensembl peptide - ENSMUSP00000133580
NCBI entrez gene - 19266     See in Manteia.
MGI - MGI:97812
RefSeq - XM_017320081
RefSeq - XM_017320067
RefSeq - XM_017320068
RefSeq - XM_017320069
RefSeq - XM_017320070
RefSeq - XM_017320071
RefSeq - XM_017320072
RefSeq - XM_017320073
RefSeq - XM_017320074
RefSeq - XM_017320075
RefSeq - XM_017320076
RefSeq - XM_017320077
RefSeq - XM_017320078
RefSeq - XM_017320079
RefSeq - XM_017320080
RefSeq - NM_011211
RefSeq - XM_006537681
RefSeq - XM_011249949
RefSeq - XM_011249950
RefSeq - XM_011249954
RefSeq - XM_011249958
RefSeq - XM_011249960
RefSeq - XM_011249961
RefSeq - XM_011249962
RefSeq - XM_011249963
RefSeq - XM_011249964
RefSeq - XM_011249965
RefSeq - XM_011249966
RefSeq - XM_017320046
RefSeq - XM_017320047
RefSeq - XM_017320048
RefSeq - XM_017320049
RefSeq - XM_017320050
RefSeq - XM_017320051
RefSeq - XM_017320052
RefSeq - XM_017320053
RefSeq - XM_017320054
RefSeq - XM_017320055
RefSeq - XM_017320056
RefSeq - XM_017320057
RefSeq - XM_017320058
RefSeq - XM_017320059
RefSeq - XM_017320060
RefSeq - XM_017320061
RefSeq - XM_017320062
RefSeq - XM_017320063
RefSeq - XM_017320064
RefSeq - XM_017320065
RefSeq - XM_017320066
RefSeq Peptide - NP_035341
swissprot - E9PVW8
swissprot - G3UWK6
swissprot - G3UX60
swissprot - G3UX75
swissprot - G3UXU8
swissprot - G3UY75
swissprot - G3UYR6
swissprot - G3UYU6
swissprot - B9EJA3
swissprot - A0A1D5RLZ1
swissprot - Q5SPA9
swissprot - E9Q7I7
swissprot - Q64487
Ensembl - ENSMUSG00000028399
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTPRDENSGALG00000015058Gallus gallus
 PTPRDENSG00000153707Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptprs / B0V2N1 / Receptor-type tyrosine-protein phosphatase S / Q13332* / protein tyrosine phosphatase, receptor type S*ENSMUSG0000001323675
Ptprf / A2A8L5 / Receptor-type tyrosine-protein phosphatase F / P10586* / protein tyrosine phosphatase, receptor type F*ENSMUSG0000003329571
Ptprm / P28828 / protein tyrosine phosphatase, receptor type, M / P28827*ENSMUSG0000003327825
Ptprk / P35822 / protein tyrosine phosphatase, receptor type, K / Q15262*ENSMUSG0000001988925
Ptprt / Q99M80 / Receptor-type tyrosine-protein phosphatase T / O14522* / protein tyrosine phosphatase, receptor type T*ENSMUSG0000005314124
B9EKR1 / Ptprz1 / protein tyrosine phosphatase, receptor type Z, polypeptide 1 / P23471* / protein tyrosine phosphatase, receptor type Z1*ENSMUSG0000006874824
Ptpru / B1AUH1 / protein tyrosine phosphatase, receptor type, U / Q92729*ENSMUSG0000002890923
Ptpra / P18052 / protein tyrosine phosphatase, receptor type, A / P18433*ENSMUSG0000002730322
Ptprg / receptor-type tyrosine-protein phosphatase gamma isoform 2 / P23470* / protein tyrosine phosphatase, receptor type G*ENSMUSG0000002174522
Ptprc / protein tyrosine phosphatase, receptor type, CENSMUSG0000002639521
Ptpre / P49446 / Receptor-type tyrosine-protein phosphatase epsilon / P23469* / protein tyrosine phosphatase, receptor type E*ENSMUSG0000004183620


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030182 neuron differentiation IDA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IMP
 biological_processGO:0050775 positive regulation of dendrite morphogenesis IMP
 biological_processGO:0050776 regulation of immune response IMP
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0097105 presynaptic membrane assembly IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IPI


Pathways (from Reactome)
Pathway description
Receptor-type tyrosine-protein phosphatases
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000071 axial skeleton hypoplasia "reduced cell number in the skeletal elements of the trunk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:55583]
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Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
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Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

Allelic Composition: Ptprdtm1Yiw/Ptprd+,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

Allelic Composition: Ptprdtm1Yiw/Ptprdtm1Yiw,Ptprstm1Mtr/Ptprs+
Genetic Background: B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr

Allelic Composition: Ptprdtm1Yiw/Ptprd+,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr

 MP:0001201 translucent skin "skin that is more transparent to light than normal " [J:15108]
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Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

 MP:0001244 thin dermal layer "reduced thickness of the dermis" [J:65030]
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Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003359 hypaxial muscle hypoplasia "reduced cell number in the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

 MP:0005162 carpoptosis "paralysis of the extensors of the wrist and fingers; most often caused by a lesion of the radial nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:81738]
Show

Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

 MP:0010934 increased subcutaneous adipose tissue amount "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003863 P60469 / Ppfia3 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 / O75145* / PTPRF interacting protein alpha 3*  / reaction / complex
 ENSMUSG00000016487 Q8C8U0 / Ppfibp1 / PTPRF interacting protein, binding protein 1 (liprin beta 1) / Q86W92* / PPFIA binding protein 1*  / reaction / complex
 ENSMUSG00000036528 O35711 / Ppfibp2 / PTPRF interacting protein, binding protein 2 (liprin beta 2) / Q8ND30* / PPFIA binding protein 2*  / complex / reaction
 ENSMUSG00000053825 Ppfia2 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 / O75334* / PTPRF interacting protein alpha 2*  / reaction / complex
 ENSMUSG00000047085 Lrrc4b / P0C192 / Leucine-rich repeat-containing protein 4B / Q9NT99* / leucine rich repeat containing 4B*  / complex / reaction
 ENSMUSG00000045045 Lrfn4 / Q80XU8 / Leucine-rich repeat and fibronectin type-III domain-containing protein 4 / Q6PJG9* / leucine rich repeat and fibronectin type III domain containing 4*  / reaction / complex
 ENSMUSG00000022514 Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*  / complex / reaction
 ENSMUSG00000059203 Q9ERS6 / Il1rapl2 / X-linked interleukin-1 receptor accessory protein-like 2 / Q9NP60* / interleukin 1 receptor accessory protein like 2*  / reaction / complex
 ENSMUSG00000037519 Ppfia1 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 / Q13136* / PTPRF interacting protein alpha 1*  / reaction / complex
 ENSMUSG00000026458 Ppfia4 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 / O75335* / PTPRF interacting protein alpha 4*  / reaction / complex






 

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