ENSMUSG00000047085


Mus musculus

Features
Gene ID: ENSMUSG00000047085
  
Biological name :Lrrc4b
  
Synonyms : Leucine-rich repeat-containing protein 4B / Lrrc4b / P0C192
  
Possible biological names infered from orthology : leucine rich repeat containing 4B / Q9NT99
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 44429018
Gene end: 44463351
  
Corresponding Affymetrix probe sets: 10552668 (MoGene1.0st)   1437183_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053123
Ensembl peptide - ENSMUSP00000123389
Ensembl peptide - ENSMUSP00000119374
NCBI entrez gene - 272381     See in Manteia.
MGI - MGI:3027390
RefSeq - NM_198250
RefSeq Peptide - NP_937893
swissprot - D3Z2D1
swissprot - D3YZP3
swissprot - P0C192
Ensembl - ENSMUSG00000047085
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrc4baENSDARG00000004597Danio rerio
 lrrc4bbENSDARG00000014792Danio rerio
 LRRC4BENSG00000131409Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrc4c / Q8C031 / Leucine-rich repeat-containing protein 4C / Q9HCJ2* / leucine rich repeat containing 4C*ENSMUSG0000005058758
Lrrc4 / Q99PH1 / Leucine-rich repeat-containing protein 4 / Q9HBW1* / leucine rich repeat containing 4*ENSMUSG0000004993952
Lingo3 / Q6GQU6 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 / P0C6S8* / leucine rich repeat and Ig domain containing 3*ENSMUSG0000005106723
Lingo2 / Q3URE9 / leucine rich repeat and Ig domain containing 2 / Q7L985*ENSMUSG0000004508323
Lingo1 / Q9D1T0 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 / Q96FE5* / leucine rich repeat and Ig domain containing 1*ENSMUSG0000004955622
Lrrn2 / leucine rich repeat protein 2, neuronal / O75325* / leucine rich repeat neuronal 2*ENSMUSG0000002644321
Lingo4 / leucine rich repeat and Ig domain containing 4 / Q6UY18*ENSMUSG0000004450521
Lrrn3 / Q8CBC6 / Leucine-rich repeat neuronal protein 3 / Q9H3W5* / leucine rich repeat neuronal 3*ENSMUSG0000003629520
Lrfn2 / Q80TG9 / Leucine-rich repeat and fibronectin type-III domain-containing protein 2 / Q9ULH4* / leucine rich repeat and fibronectin type III domain containing 2*ENSMUSG0000004049020
Lrfn1 / Q2WF71 / Leucine-rich repeat and fibronectin type III domain-containing protein 1 / Q9P244* / leucine rich repeat and fibronectin type III domain containing 1*ENSMUSG0000003060020
Lrrn1 / Q61809 / Leucine-rich repeat neuronal protein 1 / Q6UXK5* / leucine rich repeat neuronal 1*ENSMUSG0000003464819
Lrfn4 / Q80XU8 / Leucine-rich repeat and fibronectin type-III domain-containing protein 4 / Q6PJG9* / leucine rich repeat and fibronectin type III domain containing 4*ENSMUSG0000004504518
Lrfn5 / Q8BXA0 / Leucine-rich repeat and fibronectin type-III domain-containing protein 5 / Q96NI6* / leucine rich repeat and fibronectin type III domain containing 5*ENSMUSG0000003565318
Lrfn3 / Q8BLY3 / Leucine-rich repeat and fibronectin type-III domain-containing protein 3 / Q9BTN0* / leucine rich repeat and fibronectin type III domain containing 3*ENSMUSG0000003695717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR026883  Leucine-rich repeat-containing protein 4B
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0044300 cerebellar mossy fiber IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Receptor-type tyrosine-protein phosphatases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000013236 Ptprs / B0V2N1 / Receptor-type tyrosine-protein phosphatase S / Q13332* / protein tyrosine phosphatase, receptor type S*  / reaction / complex
 ENSMUSG00000033295 Ptprf / A2A8L5 / Receptor-type tyrosine-protein phosphatase F / P10586* / protein tyrosine phosphatase, receptor type F*  / reaction / complex
 ENSMUSG00000028399 Ptprd / Q64487 / protein tyrosine phosphatase, receptor type, D / P23468*  / complex / reaction






 

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