ENSMUSG00000040490


Mus musculus

Features
Gene ID: ENSMUSG00000040490
  
Biological name :Lrfn2
  
Synonyms : Leucine-rich repeat and fibronectin type-III domain-containing protein 2 / Lrfn2 / Q80TG9
  
Possible biological names infered from orthology : leucine rich repeat and fibronectin type III domain containing 2 / Q9ULH4
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: C
Gene start: 48932379
Gene end: 49097588
  
Corresponding Affymetrix probe sets: 10445816 (MoGene1.0st)   1453126_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047573
NCBI entrez gene - 70530     See in Manteia.
MGI - MGI:1917780
RefSeq - NM_027452
RefSeq Peptide - NP_081728
swissprot - Q80TG9
Ensembl - ENSMUSG00000040490
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX548062.1ENSDARG00000106248Danio rerio
 lrfn2bENSDARG00000077489Danio rerio
 LRFN2ENSGALG00000010050Gallus gallus
 LRFN2ENSG00000156564Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrfn5 / Q8BXA0 / Leucine-rich repeat and fibronectin type-III domain-containing protein 5 / Q96NI6* / leucine rich repeat and fibronectin type III domain containing 5*ENSMUSG0000003565347
Lrfn1 / Q2WF71 / Leucine-rich repeat and fibronectin type III domain-containing protein 1 / Q9P244* / leucine rich repeat and fibronectin type III domain containing 1*ENSMUSG0000003060046
Lrfn4 / Q80XU8 / Leucine-rich repeat and fibronectin type-III domain-containing protein 4 / Q6PJG9* / leucine rich repeat and fibronectin type III domain containing 4*ENSMUSG0000004504544
Lrfn3 / Q8BLY3 / Leucine-rich repeat and fibronectin type-III domain-containing protein 3 / Q9BTN0* / leucine rich repeat and fibronectin type III domain containing 3*ENSMUSG0000003695739
Lingo2 / Q3URE9 / leucine rich repeat and Ig domain containing 2 / Q7L985*ENSMUSG0000004508319
Lingo3 / Q6GQU6 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 / P0C6S8* / leucine rich repeat and Ig domain containing 3*ENSMUSG0000005106718
Lrrc4c / Q8C031 / Leucine-rich repeat-containing protein 4C / Q9HCJ2* / leucine rich repeat containing 4C*ENSMUSG0000005058718
Lrrn3 / Q8CBC6 / Leucine-rich repeat neuronal protein 3 / Q9H3W5* / leucine rich repeat neuronal 3*ENSMUSG0000003629518
Lrrc4b / P0C192 / Leucine-rich repeat-containing protein 4B / Q9NT99* / leucine rich repeat containing 4B*ENSMUSG0000004708518
Lingo1 / Q9D1T0 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 / Q96FE5* / leucine rich repeat and Ig domain containing 1*ENSMUSG0000004955617
Lrrn2 / leucine rich repeat protein 2, neuronal / O75325* / leucine rich repeat neuronal 2*ENSMUSG0000002644317
Lrrn1 / Q61809 / Leucine-rich repeat neuronal protein 1 / Q6UXK5* / leucine rich repeat neuronal 1*ENSMUSG0000003464816
Lrrc4 / Q99PH1 / Leucine-rich repeat-containing protein 4 / Q9HBW1* / leucine rich repeat containing 4*ENSMUSG0000004993916
Lingo4 / leucine rich repeat and Ig domain containing 4 / Q6UY18*ENSMUSG0000004450515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007409 axonogenesis IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vegfatm3Gne/Vegfatm3Gne
Genetic Background: involves: C57BL/6N

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Vegfatm3Gne/Vegfatm3Gne
Genetic Background: involves: C57BL/6N

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2Tg(CD2-Myb/en)5Kmw
Genetic Background: involves: C57BL/10 * CBA

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Vegfatm3Gne/Vegfatm3Gne
Genetic Background: involves: C57BL/6N

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vegfatm3Gne/Vegfatm3Gne
Genetic Background: involves: C57BL/6N

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vegfatm3Gne/Vegfatm3Gne
Genetic Background: involves: C57BL/6N

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vegfatm3Gne/Vegfatm3Gne
Genetic Background: involves: C57BL/6N

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vegfatm3Gne/Vegfatm3Gne
Genetic Background: involves: C57BL/6N

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2Tg(CD2-Myb/en)5Kmw
Genetic Background: involves: C57BL/10 * CBA

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2Tg(CD2-Myb/en)5Kmw
Genetic Background: involves: C57BL/10 * CBA

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Vegfatm3Gne/Vegfatm3Gne
Genetic Background: involves: C57BL/6N

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2Tg(CD2-Myb/en)5Kmw
Genetic Background: involves: C57BL/10 * CBA

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vegfatm3Gne/Vegfatm3Gne
Genetic Background: involves: C57BL/6N

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2Tg(CD2-Myb/en)5Kmw
Genetic Background: involves: C57BL/10 * CBA

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0012306 enhanced spatial learning "enhanced ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0020338 abnormal hippocampal pyramidal neuron dendrite morphology "structural anomaly of the highly branched tree-like process of the hippocampal neurons that have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base" [CL_1001571, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0020421 increased freezing behavior "an elevated display, frequency, or duration of freezing behavior" []
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0020551 abnormal postsynaptic density morphology "any structural anomaly of the electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymetric, neuron-neuron synapse" [GO:0014069]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024758 Rtn3 / Q9ES97 / Reticulon-3 / O95197*  / reaction / complex
 ENSMUSG00000045045 Lrfn4 / Q80XU8 / Leucine-rich repeat and fibronectin type-III domain-containing protein 4 / Q6PJG9* / leucine rich repeat and fibronectin type III domain containing 4*  / reaction / complex
 ENSMUSG00000030600 Lrfn1 / Q2WF71 / Leucine-rich repeat and fibronectin type III domain-containing protein 1 / Q9P244* / leucine rich repeat and fibronectin type III domain containing 1*  / reaction / complex
 ENSMUSG00000040490 Lrfn2 / Q80TG9 / Leucine-rich repeat and fibronectin type-III domain-containing protein 2 / Q9ULH4* / leucine rich repeat and fibronectin type III domain containing 2*  / reaction / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / reaction / complex
 ENSMUSG00000059003 Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*  / complex / reaction
 ENSMUSG00000002771 Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*  / reaction / complex
 ENSMUSG00000000881 Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*  / reaction / complex
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / reaction / complex
 ENSMUSG00000022770 Dlg1 / Q811D0 / Disks large homolog 1 / Q12959* / discs large MAGUK scaffold protein 1*  / complex / reaction
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / reaction / complex
 ENSMUSG00000020734 Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr