ENSMUSG00000020886


Mus musculus

Features
Gene ID: ENSMUSG00000020886
  
Biological name :Dlg4
  
Synonyms : Disks large homolog 4 / Dlg4 / Q62108
  
Possible biological names infered from orthology : discs large MAGUK scaffold protein 4 / P78352
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 70017085
Gene end: 70045532
  
Corresponding Affymetrix probe sets: 10377725 (MoGene1.0st)   1419580_at (Mouse Genome 430 2.0 Array)   1419581_at (Mouse Genome 430 2.0 Array)   1460261_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134545
Ensembl peptide - ENSMUSP00000126707
Ensembl peptide - ENSMUSP00000135994
Ensembl peptide - ENSMUSP00000136419
Ensembl peptide - ENSMUSP00000018700
Ensembl peptide - ENSMUSP00000104229
Ensembl peptide - ENSMUSP00000104230
Ensembl peptide - ENSMUSP00000114165
Ensembl peptide - ENSMUSP00000115206
Ensembl peptide - ENSMUSP00000121053
NCBI entrez gene - 13385     See in Manteia.
MGI - MGI:1277959
RefSeq - XM_017314248
RefSeq - NM_001109752
RefSeq - NM_007864
RefSeq - XM_006532144
RefSeq - XM_006532147
RefSeq - XM_006532148
RefSeq - XM_006532149
RefSeq - XM_006532150
RefSeq Peptide - NP_031890
RefSeq Peptide - NP_001103222
swissprot - F6TPQ6
swissprot - G3UZL5
swissprot - J3KMS4
swissprot - J3QMR8
swissprot - E9PXG2
swissprot - B1AR31
swissprot - Q62108
swissprot - E9Q3Z8
Ensembl - ENSMUSG00000020886
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlg4aENSDARG00000041926Danio rerio
 DLG4ENSG00000132535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dlg1 / Q811D0 / Disks large homolog 1 / Q12959* / discs large MAGUK scaffold protein 1*ENSMUSG0000002277074
Dlg2 / Q91XM9 / Disks large homolog 2 / Q15700* / discs large MAGUK scaffold protein 2*ENSMUSG0000005257271
Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*ENSMUSG0000000088167
Dlg5 / E9Q9R9 / Disks large homolog 5 / Q8TDM6* / discs large MAGUK scaffold protein 5*ENSMUSG0000002178224
Tjp3 / tight junction protein 3 / O95049*ENSMUSG0000003491722
Tjp1 / P39447 / tight junction protein 1 / Q07157*ENSMUSG0000003051622
Mpp5 / Q9JLB2 / membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) / Q8N3R9* / membrane palmitoylated protein 5*ENSMUSG0000002111221
Tjp2 / Q9Z0U1 / Tight junction protein ZO-2 / Q9UDY2* / AL358113.1* / tight junction protein 2*ENSMUSG0000002481221
Mpp7 / MAGUK p55 subfamily member 7 isoform 2 / Q5T2T1* / membrane palmitoylated protein 7*ENSMUSG0000005744020
Mpp6 / Q9JLB0 / membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) / Q9NZW5* / membrane palmitoylated protein 6*ENSMUSG0000003838820
Mpp2 / Q9WV34 / Mus musculus membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (Mpp2), transcript variant 1, mRNA. / Q14168* / membrane palmitoylated protein 2*ENSMUSG0000001731420
Mpp3 / membrane palmitoylated protein 3 / Q13368*ENSMUSG0000005237319
Mpp4 / Q6P7F1 / MAGUK p55 subfamily member 4 / Q96JB8* / membrane palmitoylated protein 4*ENSMUSG0000007955019
Cask / O70589 / Peripheral plasma membrane protein CASK / O14936* / calcium/calmodulin dependent serine protein kinase*ENSMUSG0000003101218
Mpp1 / P70290 / membrane protein, palmitoylated / Q00013* / membrane palmitoylated protein 1*ENSMUSG0000003140216
Guk1 / guanylate kinase 1 / Q16774*ENSMUSG0000002044410


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR016313  Disks large 1-like
 IPR019583  PDZ-associated domain of NMDA receptors
 IPR019590  Disks large homologue 1, N-terminal PEST domain
 IPR020590  Guanylate kinase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002091 negative regulation of receptor internalization ISS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0007626 locomotory behavior NAS
 biological_processGO:0016188 synaptic vesicle maturation IGI
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0035418 protein localization to synapse IEA
 biological_processGO:0035641 locomotory exploration behavior IMP
 biological_processGO:0042220 response to cocaine NAS
 biological_processGO:0043113 receptor clustering IBA
 biological_processGO:0045184 establishment of protein localization IEA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IBA
 biological_processGO:0046037 GMP metabolic process IEA
 biological_processGO:0046710 GDP metabolic process IEA
 biological_processGO:0048168 regulation of neuronal synaptic plasticity NAS
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IGI
 biological_processGO:0050806 positive regulation of synaptic transmission ISS
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0060997 dendritic spine morphogenesis IDA
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0071625 vocalization behavior IMP
 biological_processGO:0097113 AMPA glutamate receptor clustering ISS
 biological_processGO:0097120 receptor localization to synapse IBA
 biological_processGO:0099562 maintenance of postsynaptic density structure IEA
 biological_processGO:2000310 regulation of NMDA receptor activity ISS
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential ISS
 biological_processGO:2000821 regulation of grooming behavior IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISS
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IDA
 cellular_componentGO:0014069 postsynaptic density ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016323 basolateral plasma membrane IBA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0030863 cortical cytoskeleton IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IDA
 cellular_componentGO:0032839 dendrite cytoplasm ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0044224 juxtaparanode region of axon ISO
 cellular_componentGO:0044300 cerebellar mossy fiber IDA
 cellular_componentGO:0044306 neuron projection terminus IDA
 cellular_componentGO:0044309 neuron spine IDA
 cellular_componentGO:0045202 synapse IMP
 cellular_componentGO:0045211 postsynaptic membrane IDA
 cellular_componentGO:0060076 excitatory synapse IDA
 cellular_componentGO:0071944 cell periphery IDA
 cellular_componentGO:0097060 synaptic membrane IDA
 cellular_componentGO:0098794 postsynapse IDA
 cellular_componentGO:0098839 postsynaptic density membrane IDA
 molecular_functionGO:0004385 guanylate kinase activity IBA
 molecular_functionGO:0005198 structural molecule activity NAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding ISS
 molecular_functionGO:0030165 PDZ domain binding ISS
 molecular_functionGO:0031697 beta-1 adrenergic receptor binding ISS
 molecular_functionGO:0031748 D1 dopamine receptor binding ISS
 molecular_functionGO:0031812 P2Y1 nucleotide receptor binding ISS
 molecular_functionGO:0033130 acetylcholine receptor binding ISS
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IPI
 molecular_functionGO:0042043 neurexin family protein binding NAS
 molecular_functionGO:0044877 protein-containing complex binding ISS
 molecular_functionGO:0097109 neuroligin family protein binding ISS
 molecular_functionGO:0097110 scaffold protein binding IPI
 molecular_functionGO:0098919 structural constituent of postsynaptic density IC


Pathways (from Reactome)
Pathway description
Trafficking of AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation upon Ca2+ influx through NMDA receptor
Activation of Ca-permeable Kainate Receptor
RHO GTPases activate CIT
RAF/MAP kinase cascade
LGI-ADAM interactions
Neurexins and neuroligins
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000647 abnormal sebaceous gland morphology "malformation of the holocrine glands of the dermis that secrete sebum into the hair follicles" [MGI:tc]
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6-Mysm1tm1a(KOMP)Wtsi

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: L1camtm1.1Pfm/Y
Genetic Background: Not Specified

Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: L1camtm1.1Pfm/Y
Genetic Background: Not Specified

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: L1camtm1.1Pfm/Y
Genetic Background: Not Specified

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Dlg4tm2.1Grnt/Dlg4tm2.1Grnt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dlg4tm2.1Grnt/Dlg4tm2.1Grnt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: L1camtm1.1Pfm/Y
Genetic Background: Not Specified

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Dlg4tm2.1Grnt/Dlg4tm2.1Grnt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Dlg4tm2.1Grnt/Dlg4tm2.1Grnt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: L1camtm1.1Pfm/Y
Genetic Background: Not Specified

Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002802 abnormal discrimination learning "defects in the ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0002885 abnormal AMPA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of AMPA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002888 abnormal NMDA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

Allelic Composition: Dlg4tm1Rlh/Dlg4tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dlg4tm2.1Grnt/Dlg4tm2.1Grnt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0003177 decreased pain threshold "ordinarily painless stimuli, once perceived, are experienced as being painful" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:81734]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0003908 decreased stereotypic behavior "less frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [RGD:Rat Genome Database submission]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlg4tm2.1Grnt/Dlg4tm2.1Grnt
Genetic Background: involves: 129P2/OlaHsd

 MP:0009758 impaired behavioral response to cocaine "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlg4tm2.1Grnt/Dlg4tm2.1Grnt
Genetic Background: involves: 129P2/OlaHsd

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlg4tm2.1Grnt/Dlg4tm2.1Grnt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Dlg4tm2.1Grnt/Dlg4tm2.1Grnt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010166 increased response to stress-induced hyperthermia "greater increase or faster than expected increase in core body termperature in response to stress or anticipatory anxiety" [PMID:18722480]
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Allelic Composition: Dlg4tm2.1Grnt/Dlg4tm2.1Grnt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Hectd1Gt(XC266)Byg/Hectd1Gt(XC266)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dlg3tm1Grnt/Dlg3tm1Grnt,Dlg4tm1Grnt/Dlg4tm1Grnt
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Hectd1Gt(XC266)Byg/Hectd1Gt(XC266)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
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Allelic Composition: Dlg4tm2.1Grnt/Dlg4tm2.1Grnt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000881 Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*  / complex
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / complex / reaction
 ENSMUSG00000002233 Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction
 ENSMUSG00000020598 Nrcam / Q810U4 / Neuronal cell adhesion molecule / Q92823*  / reaction / complex
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / complex
 ENSMUSG00000020476 Dbnl / Q62418 / Drebrin-like protein / Q9UJU6* / drebrin like*  / reaction / complex
 ENSMUSG00000019146 Cacng2 / O88602 / Voltage-dependent calcium channel gamma-2 subunit / Q9Y698* / calcium voltage-gated channel auxiliary subunit gamma 2*  / complex
 ENSMUSG00000032356 P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*  / complex / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000067242 Lgi1 / Q9JIA1 / Leucine-rich glioma-inactivated protein 1 / O95970* / leucine rich glioma inactivated 1*  / complex / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / reaction / complex
 ENSMUSG00000061689 B1AZP2 / Dlgap4 / Disks large-associated protein 4 / Q9Y2H0* / DLG associated protein 4*  / complex
 ENSMUSG00000063887 Nlgn1 / Q99K10 / Neuroligin-1 / Q8N2Q7*  / complex
 ENSMUSG00000042388 Dlgap3 / Q6PFD5 / Disks large-associated protein 3 / O95886* / DLG associated protein 3*  / complex
 ENSMUSG00000020734 Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*  / reaction / complex
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / reaction / complex
 ENSMUSG00000051790 Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*  / complex
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction / complex
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction / complex
 ENSMUSG00000031302 Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*  / complex
 ENSMUSG00000059003 Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*  / complex / reaction
 ENSMUSG00000001985 Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*  / complex
 ENSMUSG00000002771 Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*  / reaction / complex
 ENSMUSG00000056073 Grik2 / P39087 / Glutamate receptor ionotropic, kainate 2 / Q13002* / glutamate ionotropic receptor kainate type subunit 2*  / complex
 ENSMUSG00000047495 Dlgap2 / Q8BJ42 / Disks large-associated protein 2 / Q9P1A6* / DLG associated protein 2*  / complex
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / reaction / complex
 ENSMUSG00000020723 Cacng4 / Q9JJV4 / Voltage-dependent calcium channel gamma-4 subunit / Q9UBN1* / calcium voltage-gated channel auxiliary subunit gamma 4*  / complex
 ENSMUSG00000025964 Adam23 / Q9R1V7 / Disintegrin and metalloproteinase domain-containing protein 23 / O75077* / ADAM metallopeptidase domain 23*  / reaction / complex
 ENSMUSG00000022055 Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*  / complex
 ENSMUSG00000003279 Dlgap1 / Q9D415 / Mus musculus DLG associated protein 1 (Dlgap1), transcript variant 6, mRNA. / O14490* / DLG associated protein 1*  / complex
 ENSMUSG00000066189 Cacng3 / Q9JJV5 / Voltage-dependent calcium channel gamma-3 subunit / O60359* / calcium voltage-gated channel auxiliary subunit gamma 3*  / complex
 ENSMUSG00000025892 Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSMUSG00000032017 Grik4 / Q8BMF5 / Glutamate receptor ionotropic, kainate 4 / Q16099* / glutamate ionotropic receptor kainate type subunit 4*  / complex
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSMUSG00000040537 Adam22 / Q9R1V6 / Disintegrin and metalloproteinase domain-containing protein 22 / Q9P0K1* / ADAM metallopeptidase domain 22*  / complex
 ENSMUSG00000054364 Rhob / P62746 / ras homolog family member B / P62745*  / complex / reaction
 ENSMUSG00000052374 Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*  / complex
 ENSMUSG00000040490 Lrfn2 / Q80TG9 / Leucine-rich repeat and fibronectin type-III domain-containing protein 2 / Q9ULH4* / leucine rich repeat and fibronectin type III domain containing 2*  / reaction / complex
 ENSMUSG00000030600 Lrfn1 / Q2WF71 / Leucine-rich repeat and fibronectin type III domain-containing protein 1 / Q9P244* / leucine rich repeat and fibronectin type III domain containing 1*  / complex / reaction
 ENSMUSG00000045045 Lrfn4 / Q80XU8 / Leucine-rich repeat and fibronectin type-III domain-containing protein 4 / Q6PJG9* / leucine rich repeat and fibronectin type III domain containing 4*  / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000037541 Q80Z38 / Shank2 / SH3 and multiple ankyrin repeat domains protein 2 / Q9UPX8* / SH3 and multiple ankyrin repeat domains 2*  / complex
 ENSMUSG00000001986 Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*  / reaction
 ENSMUSG00000038738 D3YZU1 / Shank1 / SH3 and multiple ankyrin repeat domains protein 1 / Q9Y566* / SH3 and multiple ankyrin repeat domains 1*  / complex






 

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