ENSMUSG00000020184


Mus musculus

Features
Gene ID: ENSMUSG00000020184
  
Biological name :Mdm2
  
Synonyms : E3 ubiquitin-protein ligase Mdm2 / Mdm2 / P23804
  
Possible biological names infered from orthology : MDM2 proto-oncogene / Q00987
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 117688875
Gene end: 117710758
  
Corresponding Affymetrix probe sets: 10372668 (MoGene1.0st)   1423605_a_at (Mouse Genome 430 2.0 Array)   1427718_a_at (Mouse Genome 430 2.0 Array)   1457929_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020408
Ensembl peptide - ENSMUSP00000100898
Ensembl peptide - ENSMUSP00000137039
NCBI entrez gene - 17246     See in Manteia.
MGI - MGI:96952
RefSeq - NM_001288586
RefSeq - NM_010786
RefSeq Peptide - NP_001275515
RefSeq Peptide - NP_034916
swissprot - J3QP04
swissprot - P23804
Ensembl - ENSMUSG00000020184
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mdm2ENSDARG00000033443Danio rerio
 MDM2ENSGALG00000009942Gallus gallus
 MDM2ENSG00000135679Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mdm4 / O35618 / transformed mouse 3T3 cell double minute 4 / O15151* / MDM4, p53 regulator*ENSMUSG0000005438723


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR001876  Zinc finger, RanBP2-type
 IPR003121  SWIB/MDM2 domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015459  Ubiquitin-protein ligase E3 MDM2
 IPR016495  p53 negative regulator Mdm2/Mdm4
 IPR028340  E3 ubiquitin-protein ligase Mdm2
 IPR036443  Zinc finger, RanBP2-type superfamily
 IPR036885  SWIB/MDM2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0002027 regulation of heart rate IGI
 biological_processGO:0003170 heart valve development IGI
 biological_processGO:0003181 atrioventricular valve morphogenesis IGI
 biological_processGO:0003203 endocardial cushion morphogenesis IMP
 biological_processGO:0003281 ventricular septum development IGI
 biological_processGO:0003283 atrial septum development IGI
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
 biological_processGO:0007089 traversing start control point of mitotic cell cycle IDA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010955 negative regulation of protein processing IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0018205 peptidyl-lysine modification ISO
 biological_processGO:0031648 protein destabilization ISO
 biological_processGO:0032026 response to magnesium ion IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0034504 protein localization to nucleus ISO
 biological_processGO:0042176 regulation of protein catabolic process ISO
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
 biological_processGO:0045184 establishment of protein localization ISO
 biological_processGO:0045472 response to ether IEA
 biological_processGO:0045787 positive regulation of cell cycle IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045931 positive regulation of mitotic cell cycle ISO
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0046827 positive regulation of protein export from nucleus IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process ISO
 biological_processGO:0051865 protein autoubiquitination ISO
 biological_processGO:0060411 cardiac septum morphogenesis IGI
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IEA
 biological_processGO:0071236 cellular response to antibiotic IEA
 biological_processGO:0071301 cellular response to vitamin B1 IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0071312 cellular response to alkaloid IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IEA
 biological_processGO:0071391 cellular response to estrogen stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071480 cellular response to gamma radiation ISO
 biological_processGO:0071494 cellular response to UV-C IEA
 biological_processGO:0072717 cellular response to actinomycin D ISO
 biological_processGO:1901797 negative regulation of signal transduction by p53 class mediator ISO
 biological_processGO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
 biological_processGO:1904404 response to formaldehyde IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IEA
 biological_processGO:1990000 amyloid fibril formation ISO
 biological_processGO:1990785 response to water-immersion restraint stress IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0002039 p53 binding ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008097 5S rRNA binding ISO
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016874 ligase activity ISO
 molecular_functionGO:0019789 SUMO transferase activity ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042975 peroxisome proliferator activated receptor binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding ISO
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISO
 molecular_functionGO:0061663 NEDD8 ligase activity ISO
 molecular_functionGO:0097110 scaffold protein binding IPI
 molecular_functionGO:0097718 disordered domain specific binding ISO


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the cytosol
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
SUMOylation of ubiquitinylation proteins
Trafficking of AMPA receptors
Ub-specific processing proteases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Stabilization of p53
Regulation of RUNX3 expression and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Mdm4tm1Glo/Mdm4+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL * C57BL/6 * SJL

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mdm2tm1Glo/Mdm2+,Trp53tm2Wahl/Trp53tm2Wahl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm2Glo/Trp53tm2Glo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mdm2tm1Glo/Mdm2+,Trp53tm1.1Tldo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprttm57(Ple26-lacZ)Ems/Y
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mdm2tm1Mep/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0000575 dark foot pads "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mdm2tm1Glo/Mdm2+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm2.1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Mdm2tm1.1Ypz/Mdm2tm1.1Ypz,Tg(IghMyc)22Bri/0
Genetic Background: B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm2.1Snj/Mdm2tm2.1Snj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Mdm2tm1.1Ypz/Mdm2tm1.1Ypz,Tg(IghMyc)22Bri/0
Genetic Background: B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1.1Ypz/Mdm2tm1.1Ypz,Tg(IghMyc)22Bri/0
Genetic Background: B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Trp53tm2Wahl/Trp53tm2Wahl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Mdm2tm1.1Ypz/Mdm2tm1.1Ypz,Tg(IghMyc)22Bri/0
Genetic Background: B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm2Glo/Trp53tm2Glo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm2Glo/Trp53tm2Glo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1Mep/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: B6.129S2-Stab2tm1.1Cger

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Glo/Trp53tm4Glo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sortm1(cre/ERT)Nat,Tg(H2-K-BCL2)1Josd/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm2Glo/Trp53tm2Glo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: Galnstm2(GALNS)Toma/Galnstm2(GALNS)Toma
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Mdm2tm1Bay/Mdm2+
Genetic Background: B6.129S7-Mdm2tm1Bay

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mir155tm1.1Rsky/Mir155tm1.1Rsky
Genetic Background: involves: 129 * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Hprttm74(Ple232-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax

Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
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Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Hprttm74(Ple232-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax

Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

Allelic Composition: Mdm2tm2.1Snj/Mdm2tm2.1Snj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mdm2tm2.1Snj/Mdm2tm2.1Snj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mdm2tm2.1Snj/Mdm2tm2.1Snj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Hprttm74(Ple232-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax

Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

Allelic Composition: Mdm2tm4.1Glo/Mdm2tm4.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm4.1Glo Trp53tm3.1Glo

 MP:0002035 leiomyosarcoma "malignant tumor derived from smooth (nonstriated) muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

Allelic Composition: Mdm2tm4.1Glo/Mdm2tm4.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm4.1Glo Trp53tm3.1Glo

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm74(Ple232-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax

Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

Allelic Composition: Mdm2tm1.1Ypz/Mdm2tm1.1Ypz,Tg(IghMyc)22Bri/0
Genetic Background: B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri

Allelic Composition: Mdm2tm1.1Ypz/Mdm2+,Tg(IghMyc)22Bri/0
Genetic Background: B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri

Allelic Composition: Mdm2tm1Glo/Mdm2+,Trp53tm1.1Tldo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mdm2tm2.1Glo/Mdm2tm2.1Glo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mdm2tm1Glo/Mdm2tm2.1Glo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mdm2tm1Glo/Mdm2tm2Glo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mdm2tm1Snj/Mdm2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mdm2tm1Bay/Mdm2tm1.2Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsf1tm1.1Echr/Hsf1tm1.1Echr,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Mep/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mdm2tm1Glo/Mdm2+,Trp53tm2Wahl/Trp53tm2Wahl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0003010 decreased mortality induced by ionizing radiation "reduced sensitivity to lethal doses of ionizing radiation such as ultraviolet light, X-rays, or gamma rays" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88888]
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Allelic Composition: Mdm2tm1Mep/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm2.1Snj/Mdm2tm2.1Snj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: C57BL/6

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mdm2tm1Glo/Mdm2+,Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129

Allelic Composition: Mdm2tm2.1Snj/Mdm2tm2.1Snj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Trp53tm1.1Tldo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mdm2tm1Glo/Mdm2+,Trp53tm2Wahl/Trp53tm2Wahl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1Mep/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mdm2tm1Glo/Mdm2+,Trp53tm2Wahl/Trp53tm2Wahl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

Allelic Composition: Mdm2tm4.1Glo/Mdm2tm4.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm4.1Glo Trp53tm3.1Glo

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1Mep/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm4tm1Glo/Mdm4+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL * C57BL/6 * SJL

Allelic Composition: Mdm2tm1Glo/Mdm2+,Trp53tm2Wahl/Trp53tm2Wahl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

Allelic Composition: Mdm2tm4.1Glo/Mdm2tm4.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm4.1Glo Trp53tm3.1Glo

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0004228 decreased cellular sensitivity to ionizing radiation "decreased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprttm74(Ple232-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax

Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1Mep/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1Mep/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm4tm1Glo/Mdm4+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL * C57BL/6 * SJL

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm2.1Snj/Mdm2tm2.1Snj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008136 enlarged Peyer s patches "increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Mdm2tm1.1Ypz/Mdm2tm1.1Ypz,Tg(IghMyc)22Bri/0
Genetic Background: B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0008924 decreased granule neuron number "reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm2Glo/Trp53tm2Glo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

Allelic Composition: Mdm2tm4.1Glo/Mdm2tm4.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm4.1Glo Trp53tm3.1Glo

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

Allelic Composition: Mdm2tm4.1Glo/Mdm2tm4.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm4.1Glo Trp53tm3.1Glo

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm2.1Snj/Mdm2tm2.1Snj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009591 liver adenocarcinoma "malignant neoplasm of epithelial cells in the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

Allelic Composition: Mdm2tm4.1Glo/Mdm2tm4.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm4.1Glo Trp53tm3.1Glo

 MP:0009687 empty decidua capsularis "the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010318 increased salivary gland tumor incidence "greater than the expected number of neoplams in the salivary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm2.1Snj/Mdm2tm2.1Snj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010343 increased lipoma incidence "greater than the expected number of a benign neoplasia derived from lipoblasts or lipocytes of white or brown fat, occurring in a specific population in a given time period" [MPATH:417]
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Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

 MP:0010363 increased fibrosarcoma incidence "greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

Allelic Composition: Mdm2tm4.1Glo/Mdm2tm4.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm4.1Glo Trp53tm3.1Glo

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Glo/Trp53tm4Glo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm2.1Glo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1.1Mep/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mdm2tm1Bay/Mdm2+,Rpl27aSfa/Rpl27a+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm2.1Kasa/Trp53tm2.1Kasa
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Glo/Trp53tm1Glo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss

Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Adv/Trp53tm1Adv
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Hprttm74(Ple232-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Hprttm74(Ple232-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax

Allelic Composition: Mdm2tm3.1Glo/Mdm2tm3.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo

Allelic Composition: Mdm2tm4.1Glo/Mdm2tm4.1Glo,Trp53tm3.1Glo/Trp53+
Genetic Background: B6.129S-Mdm2tm4.1Glo Trp53tm3.1Glo

Allelic Composition: Mdm2tm1.1Ypz/Mdm2tm1.1Ypz,Tg(IghMyc)22Bri/0
Genetic Background: B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000020326 Ccng1 / P51945 / Cyclin-G1 / P51959*  / complex / reaction
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000019146 Cacng2 / O88602 / Voltage-dependent calcium channel gamma-2 subunit / Q9Y698* / calcium voltage-gated channel auxiliary subunit gamma 2*  / complex
 ENSMUSG00000032010 Usp2 / O88623 / ubiquitin specific peptidase 2 / O75604*  / complex / reaction
 ENSMUSG00000066189 Cacng3 / Q9JJV5 / Voltage-dependent calcium channel gamma-3 subunit / O60359* / calcium voltage-gated channel auxiliary subunit gamma 3*  / complex
 ENSMUSG00000002307 Daxx / Mus musculus Fas death domain-associated protein (Daxx), transcript variant 3, mRNA. / Q9UER7* / death domain associated protein*  / reaction / complex
 ENSMUSG00000017843 Q60996 / Ppp2r5c / protein phosphatase 2, regulatory subunit B, gamma / Q13362* / protein phosphatase 2 regulatory subunit Bgamma*  / complex / reaction
 ENSMUSG00000054387 Mdm4 / O35618 / transformed mouse 3T3 cell double minute 4 / O15151* / MDM4, p53 regulator*  / complex / reaction
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / reaction / complex
 ENSMUSG00000020723 Cacng4 / Q9JJV4 / Voltage-dependent calcium channel gamma-4 subunit / Q9UBN1* / calcium voltage-gated channel auxiliary subunit gamma 4*  / complex
 ENSMUSG00000019970 Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*  / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / reaction
 ENSMUSG00000070691 Runx3 / Q64131 / Runt-related transcription factor 3 / Q13761*  / complex / reaction
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction
 ENSMUSG00000022710 Usp7 / ubiquitin specific peptidase 7 / Q93009*  / complex / reaction






 

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