ENSMUSG00000017843


Mus musculus

Features
Gene ID: ENSMUSG00000017843
  
Biological name :Ppp2r5c
  
Synonyms : Ppp2r5c / protein phosphatase 2, regulatory subunit B, gamma / Q60996
  
Possible biological names infered from orthology : protein phosphatase 2 regulatory subunit Bgamma / Q13362
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 110447120
Gene end: 110583062
  
Corresponding Affymetrix probe sets: 10398453 (MoGene1.0st)   10398455 (MoGene1.0st)   10398459 (MoGene1.0st)   10398461 (MoGene1.0st)   1425542_a_at (Mouse Genome 430 2.0 Array)   1425725_s_at (Mouse Genome 430 2.0 Array)   1425726_x_at (Mouse Genome 430 2.0 Array)   1427003_at (Mouse Genome 430 2.0 Array)   1434205_at (Mouse Genome 430 2.0 Array)   1434206_s_at (Mouse Genome 430 2.0 Array)   1455520_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152369
Ensembl peptide - ENSMUSP00000152282
Ensembl peptide - ENSMUSP00000152865
Ensembl peptide - ENSMUSP00000082053
Ensembl peptide - ENSMUSP00000105458
Ensembl peptide - ENSMUSP00000152095
NCBI entrez gene - 26931     See in Manteia.
MGI - MGI:1349475
RefSeq - XM_017315086
RefSeq - XM_006515923
RefSeq - XM_006515924
RefSeq - XM_017315081
RefSeq - XM_017315082
RefSeq - XM_017315083
RefSeq - XM_017315084
RefSeq - XM_017315085
RefSeq - NM_001081457
RefSeq - NM_001081458
RefSeq - NM_001135001
RefSeq - NM_012023
RefSeq - XM_006515917
RefSeq - XM_006515918
RefSeq - XM_006515919
RefSeq - XM_006515920
RefSeq - XM_006515921
RefSeq - XM_006515922
RefSeq Peptide - NP_036153
RefSeq Peptide - NP_001074926
RefSeq Peptide - NP_001074927
RefSeq Peptide - NP_001128473
swissprot - Q60996
swissprot - A0A1Y7VJC8
swissprot - A0A1Y7VIR0
Ensembl - ENSMUSG00000017843
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r5caENSDARG00000059083Danio rerio
 ppp2r5cbENSDARG00000031200Danio rerio
 PPP2R5CENSGALG00000029996Gallus gallus
 Q13362ENSG00000078304Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppp2r5d / protein phosphatase 2, regulatory subunit B, delta / Q14738* / protein phosphatase 2 regulatory subunit Bdelta*ENSMUSG0000005940979
Q6PD03 / Ppp2r5a / protein phosphatase 2, regulatory subunit B, alpha / Q15172* / protein phosphatase 2 regulatory subunit Balpha*ENSMUSG0000002662658
Q61151 / Ppp2r5e / protein phosphatase 2, regulatory subunit B, epsilon / Q16537* / protein phosphatase 2 regulatory subunit Bepsilon*ENSMUSG0000002105158
Q6PD28 / Ppp2r5b / protein phosphatase 2, regulatory subunit B, beta / Q15173* / protein phosphatase 2 regulatory subunit Bbeta*ENSMUSG0000002477756


Protein motifs (from Interpro)
Interpro ID Name
 IPR002554  Protein phosphatase 2A, regulatory B subunit, B56
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 cellular_componentGO:0000159 protein phosphatase type 2A complex ISS
 cellular_componentGO:0000775 chromosome, centromeric region ISS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011392 increased fetal cardiomyocyte apoptosis "increase in the number of fetal cardiomyocytes undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003541 Ier3 / immediate early response 3 / P46695*  / reaction / complex
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / complex / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction / complex
 ENSMUSG00000020326 Ccng1 / P51945 / Cyclin-G1 / P51959*  / reaction / complex
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction






 

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