ENSG00000078304


Homo sapiens

Features
Gene ID: ENSG00000078304
  
Biological name :PPP2R5C
  
Synonyms : PPP2R5C / protein phosphatase 2 regulatory subunit Bgamma / Q13362
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.31
Gene start: 101761798
Gene end: 101927989
  
Corresponding Affymetrix probe sets: 1554364_at (Human Genome U133 Plus 2.0 Array)   1554365_a_at (Human Genome U133 Plus 2.0 Array)   1557718_at (Human Genome U133 Plus 2.0 Array)   201877_s_at (Human Genome U133 Plus 2.0 Array)   213305_s_at (Human Genome U133 Plus 2.0 Array)   214083_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454124
Ensembl peptide - ENSP00000453906
Ensembl peptide - ENSP00000454035
Ensembl peptide - ENSP00000262239
Ensembl peptide - ENSP00000329009
Ensembl peptide - ENSP00000333905
Ensembl peptide - ENSP00000408389
Ensembl peptide - ENSP00000412324
Ensembl peptide - ENSP00000450525
Ensembl peptide - ENSP00000450626
Ensembl peptide - ENSP00000450743
Ensembl peptide - ENSP00000450816
Ensembl peptide - ENSP00000450867
Ensembl peptide - ENSP00000450931
Ensembl peptide - ENSP00000451179
Ensembl peptide - ENSP00000452124
Ensembl peptide - ENSP00000452500
Ensembl peptide - ENSP00000452533
Ensembl peptide - ENSP00000452630
Ensembl peptide - ENSP00000452632
Ensembl peptide - ENSP00000453875
NCBI entrez gene - 5527     See in Manteia.
OMIM - 601645
RefSeq - XM_017021424
RefSeq - NM_001161725
RefSeq - NM_001161726
RefSeq - NM_001352913
RefSeq - NM_001352914
RefSeq - NM_001352915
RefSeq - NM_002719
RefSeq - NM_178586
RefSeq - NM_178587
RefSeq - XM_005267819
RefSeq - XM_005267820
RefSeq - XM_005267822
RefSeq - XM_005267823
RefSeq - XM_005267824
RefSeq - XM_005267826
RefSeq - XM_005267827
RefSeq - XM_011536914
RefSeq - XM_011536915
RefSeq - XM_011536916
RefSeq - XM_011536918
RefSeq - XM_011536919
RefSeq - XM_011536920
RefSeq - XM_011536921
RefSeq - XM_017021422
RefSeq - XM_017021423
RefSeq Peptide - NP_001339841
RefSeq Peptide - NP_001339842
RefSeq Peptide - NP_001339843
RefSeq Peptide - NP_001339844
RefSeq Peptide - NP_002710
RefSeq Peptide - NP_848701
RefSeq Peptide - NP_848702
RefSeq Peptide - NP_001155197
RefSeq Peptide - NP_001155198
swissprot - H0YJZ3
swissprot - H0YK25
swissprot - H0YK26
swissprot - H0YN58
swissprot - H0YN84
swissprot - H0YNJ3
swissprot - H0YNR8
swissprot - Q96B13
swissprot - G3V292
swissprot - Q13362
swissprot - G3V2U3
swissprot - G3V5T2
swissprot - H0YJ12
swissprot - H0YJ35
swissprot - H0YJ49
swissprot - H0YJ75
swissprot - H0YJU0
Ensembl - ENSG00000078304
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r5caENSDARG00000059083Danio rerio
 ppp2r5cbENSDARG00000031200Danio rerio
 PPP2R5CENSGALG00000029996Gallus gallus
 Q60996ENSMUSG00000017843Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q14738 / PPP2R5D / protein phosphatase 2 regulatory subunit BdeltaENSG0000011264077
Q15172 / PPP2R5A / protein phosphatase 2 regulatory subunit BalphaENSG0000006602755
Q16537 / PPP2R5E / protein phosphatase 2 regulatory subunit BepsilonENSG0000015400155
Q15173 / PPP2R5B / protein phosphatase 2 regulatory subunit BbetaENSG0000006897154


Protein motifs (from Interpro)
Interpro ID Name
 IPR002554  Protein phosphatase 2A, regulatory B subunit, B56
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling TAS
 cellular_componentGO:0000159 protein phosphatase type 2A complex NAS
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016021 integral component of membrane IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0019888 protein phosphatase regulator activity NAS


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Misspliced GSK3beta mutants stabilize beta-catenin
S33 mutants of beta-catenin arent phosphorylated
S37 mutants of beta-catenin arent phosphorylated
S45 mutants of beta-catenin arent phosphorylated
T41 mutants of beta-catenin arent phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction / complex
 ENSG00000135679 MDM2 / Q00987 / MDM2 proto-oncogene  / reaction / complex
 ENSG00000137331 IER3 / P46695 / immediate early response 3  / reaction / complex
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / complex / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000113328 CCNG1 / P51959 / cyclin G1  / complex / reaction






 

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contact: otassy@igbmc.fr