ENSG00000137331


Homo sapiens

Features
Gene ID: ENSG00000137331
  
Biological name :IER3
  
Synonyms : IER3 / immediate early response 3 / P46695
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.33
Gene start: 30743199
Gene end: 30744554
  
Corresponding Affymetrix probe sets: 201631_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000259874
Ensembl peptide - ENSP00000365557
NCBI entrez gene - 8870     See in Manteia.
OMIM - 602996
RefSeq - NM_003897
RefSeq Peptide - NP_003888
swissprot - A0A1U9X7X2
swissprot - P46695
swissprot - Q5ST79
Ensembl - ENSG00000137331
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Ier3ENSMUSG00000003541Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024829  Radiation-inducible immediate-early gene IEX-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0010941 regulation of cell death IBA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:2001020 regulation of response to DNA damage stimulus IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000078304 Q13362 / PPP2R5C / protein phosphatase 2 regulatory subunit Bgamma  / complex / reaction
 ENSG00000068971 Q15173 / PPP2R5B / protein phosphatase 2 regulatory subunit Bbeta  / complex / reaction
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / complex / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / complex / reaction






 

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contact: otassy@igbmc.fr