ENSMUSG00000003541


Mus musculus

Features
Gene ID: ENSMUSG00000003541
  
Biological name :Ier3
  
Synonyms : Ier3 / immediate early response 3
  
Possible biological names infered from orthology : P46695
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 35821684
Gene end: 35822923
  
Corresponding Affymetrix probe sets: 10444890 (MoGene1.0st)   1419647_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003635
NCBI entrez gene - 15937     See in Manteia.
MGI - MGI:104814
RefSeq - NM_133662
RefSeq Peptide - NP_598423
swissprot - Q91VZ5
Ensembl - ENSMUSG00000003541
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IER3ENSG00000137331Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024829  Radiation-inducible immediate-early gene IEX-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:2001020 regulation of response to DNA damage stimulus IEA
 cellular_componentGO:0005634 nucleus IEA


Pathways (from Reactome)
Pathway description
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pbx1tm1Mlc/Pbx1tm2.1Mlc
Genetic Background: involves: 129S6/SvEvTac

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pbx1tm1Mlc/Pbx1tm2.1Mlc
Genetic Background: involves: 129S6/SvEvTac

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pbx1tm1Mlc/Pbx1tm2.1Mlc
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pbx1tm1Mlc/Pbx1tm2.1Mlc
Genetic Background: involves: 129S6/SvEvTac

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pbx1tm1Mlc/Pbx1tm2.1Mlc
Genetic Background: involves: 129S6/SvEvTac

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008556 abnormal tumor necrosis factor secretion "anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

 MP:0010219 increased T-helper 17 cell number "increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024777 Q6PD28 / Ppp2r5b / protein phosphatase 2, regulatory subunit B, beta / Q15173* / protein phosphatase 2 regulatory subunit Bbeta*  / complex / reaction
 ENSMUSG00000017843 Q60996 / Ppp2r5c / protein phosphatase 2, regulatory subunit B, gamma / Q13362* / protein phosphatase 2 regulatory subunit Bgamma*  / complex / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction / complex
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / complex / reaction






 

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