ENSMUSG00000024777


Mus musculus

Features
Gene ID: ENSMUSG00000024777
  
Biological name :Ppp2r5b
  
Synonyms : Ppp2r5b / protein phosphatase 2, regulatory subunit B, beta / Q6PD28
  
Possible biological names infered from orthology : protein phosphatase 2 regulatory subunit Bbeta / Q15173
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 6227765
Gene end: 6235872
  
Corresponding Affymetrix probe sets: 10465395 (MoGene1.0st)   1426811_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025695
NCBI entrez gene - 225849     See in Manteia.
MGI - MGI:2388480
RefSeq - NM_198168
RefSeq Peptide - NP_937811
swissprot - Q6PD28
Ensembl - ENSMUSG00000024777
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r5bENSDARG00000054931Danio rerio
 Q15173ENSG00000068971Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6PD03 / Ppp2r5a / protein phosphatase 2, regulatory subunit B, alpha / Q15172* / protein phosphatase 2 regulatory subunit Balpha*ENSMUSG0000002662668
Q61151 / Ppp2r5e / protein phosphatase 2, regulatory subunit B, epsilon / Q16537* / protein phosphatase 2 regulatory subunit Bepsilon*ENSMUSG0000002105168
Ppp2r5d / protein phosphatase 2, regulatory subunit B, delta / Q14738* / protein phosphatase 2 regulatory subunit Bdelta*ENSMUSG0000005940962
Q60996 / Ppp2r5c / protein phosphatase 2, regulatory subunit B, gamma / Q13362* / protein phosphatase 2 regulatory subunit Bgamma*ENSMUSG0000001784359


Protein motifs (from Interpro)
Interpro ID Name
 IPR002554  Protein phosphatase 2A, regulatory B subunit, B56
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0031952 regulation of protein autophosphorylation IEA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 cellular_componentGO:0000159 protein phosphatase type 2A complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003541 Ier3 / immediate early response 3 / P46695*  / reaction / complex
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction / complex
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / complex / reaction






 

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