ENSMUSG00000059409


Mus musculus

Features
Gene ID: ENSMUSG00000059409
  
Biological name :Ppp2r5d
  
Synonyms : Ppp2r5d / protein phosphatase 2, regulatory subunit B, delta
  
Possible biological names infered from orthology : protein phosphatase 2 regulatory subunit Bdelta / Q14738
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 46682991
Gene end: 46705002
  
Corresponding Affymetrix probe sets: 10451434 (MoGene1.0st)   1450560_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002839
NCBI entrez gene - 21770     See in Manteia.
MGI - MGI:2388481
RefSeq - XM_006524029
RefSeq - NM_001357684
RefSeq - NM_009358
RefSeq Peptide - NP_033384
RefSeq Peptide - NP_001344613
swissprot - Q91V89
Ensembl - ENSMUSG00000059409
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r5dENSDARG00000014428Danio rerio
 PPP2R5DENSGALG00000040005Gallus gallus
 Q14738ENSG00000112640Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60996 / Ppp2r5c / protein phosphatase 2, regulatory subunit B, gamma / Q13362* / protein phosphatase 2 regulatory subunit Bgamma*ENSMUSG0000001784369
Q61151 / Ppp2r5e / protein phosphatase 2, regulatory subunit B, epsilon / Q16537* / protein phosphatase 2 regulatory subunit Bepsilon*ENSMUSG0000002105154
Q6PD03 / Ppp2r5a / protein phosphatase 2, regulatory subunit B, alpha / Q15172* / protein phosphatase 2 regulatory subunit Balpha*ENSMUSG0000002662653
Q6PD28 / Ppp2r5b / protein phosphatase 2, regulatory subunit B, beta / Q15173* / protein phosphatase 2 regulatory subunit Bbeta*ENSMUSG0000002477752


Protein motifs (from Interpro)
Interpro ID Name
 IPR002554  Protein phosphatase 2A, regulatory B subunit, B56
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation ISO
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010976 positive regulation of neuron projection development ISO
 biological_processGO:0031952 regulation of protein autophosphorylation ISO
 biological_processGO:0035307 positive regulation of protein dephosphorylation IDA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway ISO
 biological_processGO:0071363 cellular response to growth factor stimulus ISO
 cellular_componentGO:0000159 protein phosphatase type 2A complex IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019888 protein phosphatase regulator activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm38.1(CAG-GCaMP3)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

Allelic Composition: Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan,Tg(Thy1-MAPT)5Vln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm38.1(CAG-GCaMP3)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

Allelic Composition: Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan,Tg(Thy1-MAPT)5Vln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm38.1(CAG-GCaMP3)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

Allelic Composition: Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan,Tg(Thy1-MAPT)5Vln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000001034 Mapk7 / Q9WVS8 / Mitogen-activated protein kinase 7 / Q13164*  / reaction






 

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