ENSMUSG00000001034


Mus musculus

Features
Gene ID: ENSMUSG00000001034
  
Biological name :Mapk7
  
Synonyms : Mapk7 / Mitogen-activated protein kinase 7 / Q9WVS8
  
Possible biological names infered from orthology : Q13164
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B2
Gene start: 61488812
Gene end: 61494406
  
Corresponding Affymetrix probe sets: 10386723 (MoGene1.0st)   1418060_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078087
Ensembl peptide - ENSMUSP00000098646
Ensembl peptide - ENSMUSP00000104354
Ensembl peptide - ENSMUSP00000116084
NCBI entrez gene - 23939     See in Manteia.
MGI - MGI:1346347
RefSeq - NM_001291033
RefSeq - NM_001291034
RefSeq - NM_001291035
RefSeq - XM_006533286
RefSeq - NM_001291037
RefSeq - NM_011841
RefSeq - NM_001291036
RefSeq - XM_006533285
RefSeq - XM_006533277
RefSeq - XM_006533280
RefSeq - XM_006533281
RefSeq - XM_006533284
RefSeq Peptide - NP_001277963
RefSeq Peptide - NP_001277962
RefSeq Peptide - NP_001277964
RefSeq Peptide - NP_001277965
RefSeq Peptide - NP_001277966
RefSeq Peptide - NP_035971
swissprot - Q9WVS8
swissprot - Q5NCN8
swissprot - Z4YLV8
Ensembl - ENSMUSG00000001034
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk7ENSDARG00000023110Danio rerio
 MAPK7ENSG00000166484Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*ENSMUSG0000006306523
Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*ENSMUSG0000006335822
Mapk6 / Q61532 / Mitogen-activated protein kinase 6 / Q16659*ENSMUSG0000004268822
Mapk15 / Q80Y86 / Mitogen-activated protein kinase 15 / Q8TD08*ENSMUSG0000006370421
Nlk / O54949 / Serine/threonine-protein kinase NLK / Q9UBE8* / nemo like kinase*ENSMUSG0000001737621
Mapk4 / Q6P5G0 / Mitogen-activated protein kinase 4 / P31152*ENSMUSG0000002455818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0034115 negative regulation of heterotypic cell-cell adhesion ISO
 biological_processGO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress ISO
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 biological_processGO:0045765 regulation of angiogenesis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0051247 positive regulation of protein metabolic process ISO
 biological_processGO:0060761 negative regulation of response to cytokine stimulus ISO
 biological_processGO:0070301 cellular response to hydrogen peroxide ISO
 biological_processGO:0070377 negative regulation of ERK5 cascade IDA
 biological_processGO:0071310 cellular response to organic substance IBA
 biological_processGO:0071363 cellular response to growth factor stimulus ISO
 biological_processGO:0071499 cellular response to laminar fluid shear stress ISO
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus ISO
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process ISO
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016605 PML body ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding ISO


Pathways (from Reactome)
Pathway description
ERK/MAPK targets
Signalling to ERK5
ERKs are inactivated
Senescence-Associated Secretory Phenotype (SASP)
Gastrin-CREB signalling pathway via PKC and MAPK
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000264 failure of vascular branching "failure of vasculature to form divisions (offshoots)" [J:53370]
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Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001619 abnormal vascular permeability "anomaly in the ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Tek-cre)12Flv/0
Genetic Background: Not Specified

Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

 MP:0003542 abnormal vascular endothelial cell development "malformation or aberrant differentiation of the cells that line the vasculature" [J:95387, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0003649 reduced right ventricle 
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Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Tek-cre)12Flv/0
Genetic Background: Not Specified

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

 MP:0006341 small first branchial arch "reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0006344 small second branchial arch "reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Tek-cre)12Flv/0
Genetic Background: Not Specified

Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
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Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0011667 double outlet right ventricle with atrioventricular septal defect "a form of DORV in which there is also a complete atrioventricular canal" [MGI:csmith]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0012252 abnormal septum transversum morphology "any structural anomaly of the thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions; the cranial part of the septum transversum gives rise to the central tendon of the diaphragm and is the origin of the myoblasts that invade the pleuroperitoneal folds resulting in the formation of the muscular diaphragm, and the caudal part of the septum transversum is invaded by the hepatic diverticulum which divides within it to form the liver and thus gives rise to the ventral mesentery of the foregut" [MGI:anna, VHOG:0000019]
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Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
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Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Flgft/Flgft
Genetic Background: STOCK a/a Tmem79ma Flgft/J

Allelic Composition: Mapk7tm1.1Ctr/Mapk7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003518 Dusp3 / Q9D7X3 / Dual specificity protein phosphatase 3 / P51452* / dual specificity phosphatase 3*  / reaction
 ENSMUSG00000059409 Ppp2r5d / protein phosphatase 2, regulatory subunit B, delta / Q14738* / protein phosphatase 2 regulatory subunit Bdelta*  / reaction
 ENSMUSG00000019960 Dusp6 / Q9DBB1 / Dual specificity protein phosphatase 6 / Q16828* / dual specificity phosphatase 6*  / reaction
 ENSMUSG00000031530 Dusp4 / Q8BFV3 / Dual specificity protein phosphatase 4 / Q13115* / dual specificity phosphatase 4*  / reaction
 ENSMUSG00000031309 P18654 / Rps6ka3 / ribosomal protein S6 kinase polypeptide 3 / P51812* / ribosomal protein S6 kinase A3*  / reaction
 ENSMUSG00000003644 P18653 / Rps6ka1 / ribosomal protein S6 kinase polypeptide 1 / Q15418* / ribosomal protein S6 kinase A1*  / reaction
 ENSMUSG00000023809 Q9WUT3 / Rps6ka2 / ribosomal protein S6 kinase, polypeptide 2 / Q15349* / ribosomal protein S6 kinase A2*  / reaction
 ENSMUSG00000053716 Dusp7 / Q91Z46 / Dual specificity protein phosphatase 7 / Q16829* / dual specificity phosphatase 7*  / reaction






 

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