ENSMUSG00000003518


Mus musculus

Features
Gene ID: ENSMUSG00000003518
  
Biological name :Dusp3
  
Synonyms : Dual specificity protein phosphatase 3 / Dusp3 / Q9D7X3
  
Possible biological names infered from orthology : dual specificity phosphatase 3 / P51452
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 101971143
Gene end: 101987013
  
Corresponding Affymetrix probe sets: 10391513 (MoGene1.0st)   1425608_at (Mouse Genome 430 2.0 Array)   1434472_at (Mouse Genome 430 2.0 Array)   1456769_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135821
Ensembl peptide - ENSMUSP00000135384
Ensembl peptide - ENSMUSP00000135443
Ensembl peptide - ENSMUSP00000003612
Ensembl peptide - ENSMUSP00000102790
Ensembl peptide - ENSMUSP00000102791
Ensembl peptide - ENSMUSP00000135343
NCBI entrez gene - 72349     See in Manteia.
MGI - MGI:1919599
RefSeq - XM_006534306
RefSeq - NM_028207
RefSeq - XM_006534305
RefSeq Peptide - NP_082483
swissprot - B1AQF4
swissprot - H3BKD1
swissprot - Q9D7X3
swissprot - H3BKL8
swissprot - H3BLK2
swissprot - Q3V2Y9
Ensembl - ENSMUSG00000003518
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp3aENSDARG00000061255Danio rerio
 dusp3bENSDARG00000060130Danio rerio
 DUSP3ENSGALG00000035369Gallus gallus
 DUSP3ENSG00000108861Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dusp27 / Q148W8 / Inactive dual specificity phosphatase 27 / Q5VZP5* / dual specificity phosphatase 27, atypical*ENSMUSG0000002656440
Dupd1 / Q8BK84 / Dual specificity phosphatase DUPD1 / Q68J44* / dual specificity phosphatase and pro isomerase domain containing 1*ENSMUSG0000006382140
Dusp26 / Q9D700 / Mus musculus dual specificity phosphatase 26 (putative) (Dusp26), transcript variant 2, mRNA. / Q9BV47* / dual specificity phosphatase 26*ENSMUSG0000003966139
Q9QYJ7 / Dusp13 / Q6B8I0 / Dual specificity protein phosphatase 13 isoform A / Q9UII6* / Q6B8I1* / dual specificity phosphatase 13*ENSMUSG0000002176838
Dusp19 / dual specificity phosphatase 19 / Q8WTR2*ENSMUSG0000002700128
Dusp22 / Q99N11 / Dual specificity protein phosphatase 22 / Q9NRW4* / dual specificity phosphatase 22*ENSMUSG0000006925527
Dusp15 / Q8R4V2 / Dual specificity protein phosphatase 15 / Q9H1R2* / dual specificity phosphatase 15*ENSMUSG0000004266225
Dusp12 / Q9D0T2 / Mus musculus dual specificity phosphatase 12 (Dusp12), transcript variant 3, mRNA. / Q9UNI6* / dual specificity phosphatase 12*ENSMUSG0000002665925
Dusp14 / Q9JLY7 / Dual specificity protein phosphatase 14 / O95147* / dual specificity phosphatase 14*ENSMUSG0000001864825
Q60969 / Gm14698 / predicted gene 14698 / STYX* / Q8WUJ0* / serine/threonine/tyrosine interacting protein*ENSMUSG0000007174825
Styx / Q60969 / serine/threonine/tyrosine interaction protein / Q8WUJ0* / serine/threonine/tyrosine interacting protein*ENSMUSG0000005320525
Dusp21 / Q9D9D8 / Dual specificity phosphatase 21 / Q9H596*ENSMUSG0000002504323
Dusp18 / Q8VE01 / Dual specificity protein phosphatase 18 / Q8NEJ0* / dual specificity phosphatase 18*ENSMUSG0000004720522
Dusp28 / Q8BTR5 / Dual specificity phosphatase 28 / Q4G0W2*ENSMUSG0000004706722


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020405  Atypical dual specificity phosphatase, subfamily A
 IPR020417  Atypical dual specificity phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IEA
 biological_processGO:0050868 negative regulation of T cell activation IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IDA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0033549 MAP kinase phosphatase activity IEA


Pathways (from Reactome)
Pathway description
ERKs are inactivated


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000001034 Mapk7 / Q9WVS8 / Mitogen-activated protein kinase 7 / Q13164*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000002205 Vrk3 / Q8K3G5 / vaccinia related kinase 3 / Q8IV63*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr