ENSGALG00000035369


Gallus gallus

Features
Gene ID: ENSGALG00000035369
  
Biological name :DUSP3
  
Synonyms : dual specificity phosphatase 3 / DUSP3
  
Possible biological names infered from orthology : Dual specificity protein phosphatase 3 / P51452 / Q9D7X3
  
Species: Gallus gallus
  
Chr. number: 27
Strand: 1
Band:
Gene start: 3491886
Gene end: 3498724
  
Corresponding Affymetrix probe sets: Gga.8205.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052455
Ensembl peptide - ENSGALP00000064641
NCBI entrez gene - 425527     See in Manteia.
RefSeq - XM_015299465
swissprot - A0A1D5PI23
swissprot - A0A1L1S0I4
Ensembl - ENSGALG00000035369
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp3aENSDARG00000061255Danio rerio
 dusp3bENSDARG00000060130Danio rerio
 DUSP3ENSG00000108861Homo sapiens
 Dusp3ENSMUSG00000003518Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000000500742
DUSP26 / dual specificity phosphatase 26 / Q9BV47* / Q9D700* / Mus musculus dual specificity phosphatase 26 (putative) (Dusp26), transcript variant 2, mRNA.*ENSGALG0000000163342
DUSP27 / dual specificity phosphatase 27, atypical / Q148W8* / Q5VZP5* / Inactive dual specificity phosphatase 27 *ENSGALG0000001545339
DUPD1 / dual specificity phosphatase and pro isomerase domain containing 1 / Q68J44* / Q8BK84* / Dual specificity phosphatase DUPD1 *ENSGALG0000000501938
DUSP13 / dual specificity phosphatase 13 / Q9QYJ7* / Q9UII6* / Q6B8I0* / Q6B8I1* / Dual specificity protein phosphatase 13 isoform A *ENSGALG0000000501737
DUSP19 / dual specificity phosphatase 19 / Q8WTR2*ENSGALG0000004326828
Q9H596* / Q8NEJ0* / Q8VE01* / Q9D9D8* / DUSP18* / DUSP21* / dual specificity phosphatase 21* / dual specificity phosphatase 18* / Dual specificity protein phosphatase 18 *ENSGALG0000000776526
DUSP14 / dual specificity phosphatase 14 / O95147* / Q9JLY7* / Dual specificity protein phosphatase 14 *ENSGALG0000002764125
ENSGALG0000000575424
DUSP22 / dual specificity phosphatase 22 / Q99N11* / Q9NRW4* / Dual specificity protein phosphatase 22 *ENSGALG0000002739724
DUSP15 / dual specificity phosphatase 15 / Q8R4V2* / Q9H1R2* / Dual specificity protein phosphatase 15 *ENSGALG0000002101723
DUSP12 / dual specificity phosphatase 12 / Q9D0T2* / Q9UNI6* / Mus musculus dual specificity phosphatase 12 (Dusp12), transcript variant 3, mRNA.*ENSGALG0000000708422
DUSP28 / dual specificity phosphatase 28 / Q4G0W2* / Q8BTR5*ENSGALG0000000039921


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020405  Atypical dual specificity phosphatase, subfamily A
 IPR020417  Atypical dual specificity phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IEA
 biological_processGO:0050868 negative regulation of T cell activation IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0033549 MAP kinase phosphatase activity IEA


Pathways (from Reactome)
Pathway description
ERKs are inactivated


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction






 

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