ENSG00000108861


Homo sapiens

Features
Gene ID: ENSG00000108861
  
Biological name :DUSP3
  
Synonyms : dual specificity phosphatase 3 / DUSP3 / P51452
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.31
Gene start: 43766121
Gene end: 43778988
  
Corresponding Affymetrix probe sets: 201536_at (Human Genome U133 Plus 2.0 Array)   201537_s_at (Human Genome U133 Plus 2.0 Array)   201538_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000226004
Ensembl peptide - ENSP00000467424
Ensembl peptide - ENSP00000468604
Ensembl peptide - ENSP00000466069
NCBI entrez gene - 1845     See in Manteia.
OMIM - 600183
RefSeq - NM_004090
RefSeq Peptide - NP_004081
swissprot - P51452
swissprot - K7ELG5
swissprot - K7EPK5
swissprot - K7ES89
Ensembl - ENSG00000108861
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp3aENSDARG00000061255Danio rerio
 dusp3bENSDARG00000060130Danio rerio
 DUSP3ENSGALG00000035369Gallus gallus
 Dusp3ENSMUSG00000003518Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUSP13 / Q6B8I1 / Q9UII6 / dual specificity phosphatase 13ENSG0000007939340
DUPD1 / Q68J44 / dual specificity phosphatase and pro isomerase domain containing 1ENSG0000018871640
DUSP26 / Q9BV47 / dual specificity phosphatase 26ENSG0000013387839
DUSP27 / Q5VZP5 / dual specificity phosphatase 27, atypicalENSG0000019884237
DUSP19 / Q8WTR2 / dual specificity phosphatase 19ENSG0000016299927
DUSP14 / O95147 / dual specificity phosphatase 14ENSG0000027602326
DUSP22 / Q9NRW4 / dual specificity phosphatase 22ENSG0000011267926
STYX / Q8WUJ0 / serine/threonine/tyrosine interacting proteinENSG0000019825225
DUSP12 / Q9UNI6 / dual specificity phosphatase 12ENSG0000008172124
DUSP15 / Q9H1R2 / dual specificity phosphatase 15ENSG0000014959924
DUSP18 / Q8NEJ0 / dual specificity phosphatase 18ENSG0000016706523
DUSP21 / Q9H596 / dual specificity phosphatase 21ENSG0000018903723
DUSP28 / Q4G0W2 / dual specificity phosphatase 28ENSG0000018854220


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020405  Atypical dual specificity phosphatase, subfamily A
 IPR020417  Atypical dual specificity phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IMP
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IMP
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0046329 negative regulation of JNK cascade IMP
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IDA
 biological_processGO:0050868 negative regulation of T cell activation IDA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IDA
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0033549 MAP kinase phosphatase activity IMP


Pathways (from Reactome)
Pathway description
ERKs are inactivated


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000166484 MAPK7 / Q13164 / mitogen-activated protein kinase 7  / reaction
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000105053 VRK3 / Q8IV63 / vaccinia related kinase 3  / complex






 

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