ENSG00000162999


Homo sapiens

Features
Gene ID: ENSG00000162999
  
Biological name :DUSP19
  
Synonyms : dual specificity phosphatase 19 / DUSP19 / Q8WTR2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q32.1
Gene start: 183078559
Gene end: 183100005
  
Corresponding Affymetrix probe sets: 1552705_at (Human Genome U133 Plus 2.0 Array)   1552708_a_at (Human Genome U133 Plus 2.0 Array)   1555598_a_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000343905
Ensembl peptide - ENSP00000346160
NCBI entrez gene - 142679     See in Manteia.
OMIM - 611437
RefSeq - NM_001321519
RefSeq - NM_001142314
RefSeq - NM_080876
RefSeq Peptide - NP_001135786
RefSeq Peptide - NP_001308448
RefSeq Peptide - NP_543152
swissprot - Q8WTR2
Ensembl - ENSG00000162999
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp19aENSDARG00000040490Danio rerio
 dusp19bENSDARG00000045200Danio rerio
 DUSP19ENSGALG00000043268Gallus gallus
 Dusp19ENSMUSG00000027001Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STYX / Q8WUJ0 / serine/threonine/tyrosine interacting proteinENSG0000019825227
DUSP12 / Q9UNI6 / dual specificity phosphatase 12ENSG0000008172124
DUSP14 / O95147 / dual specificity phosphatase 14ENSG0000027602324
DUSP13 / Q6B8I1 / Q9UII6 / dual specificity phosphatase 13ENSG0000007939323
DUSP22 / Q9NRW4 / dual specificity phosphatase 22ENSG0000011267923
DUSP3 / P51452 / dual specificity phosphatase 3ENSG0000010886123
DUSP27 / Q5VZP5 / dual specificity phosphatase 27, atypicalENSG0000019884223
DUPD1 / Q68J44 / dual specificity phosphatase and pro isomerase domain containing 1ENSG0000018871623
DUSP26 / Q9BV47 / dual specificity phosphatase 26ENSG0000013387823
DUSP21 / Q9H596 / dual specificity phosphatase 21ENSG0000018903722
DUSP18 / Q8NEJ0 / dual specificity phosphatase 18ENSG0000016706522
DUSP15 / Q9H1R2 / dual specificity phosphatase 15ENSG0000014959921
DUSP28 / Q4G0W2 / dual specificity phosphatase 28ENSG0000018854221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR020417  Atypical dual specificity phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity ISS
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043410 positive regulation of MAPK cascade ISS
 biological_processGO:0043507 positive regulation of JUN kinase activity ISS
 biological_processGO:0043508 negative regulation of JUN kinase activity ISS
 biological_processGO:0045860 positive regulation of protein kinase activity ISS
 biological_processGO:0046329 negative regulation of JNK cascade ISS
 biological_processGO:0046330 positive regulation of JNK cascade ISS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity ISS
 molecular_functionGO:0005078 MAP-kinase scaffold activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0008579 JUN kinase phosphatase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0030295 protein kinase activator activity ISS
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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