ENSG00000112679


Homo sapiens

Features
Gene ID: ENSG00000112679
  
Biological name :DUSP22
  
Synonyms : dual specificity phosphatase 22 / DUSP22 / Q9NRW4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p25.3
Gene start: 291630
Gene end: 351355
  
Corresponding Affymetrix probe sets: 218845_at (Human Genome U133 Plus 2.0 Array)   226440_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000475061
Ensembl peptide - ENSP00000475106
Ensembl peptide - ENSP00000345281
Ensembl peptide - ENSP00000397459
Ensembl peptide - ENSP00000474000
Ensembl peptide - ENSP00000474082
Ensembl peptide - ENSP00000474330
Ensembl peptide - ENSP00000474450
Ensembl peptide - ENSP00000474505
Ensembl peptide - ENSP00000474646
Ensembl peptide - ENSP00000474827
NCBI entrez gene - 56940     See in Manteia.
OMIM - 616778
RefSeq - NM_001286555
RefSeq - NM_020185
RefSeq Peptide - NP_001273484
RefSeq Peptide - NP_064570
swissprot - Q9NRW4
swissprot - S4R378
swissprot - S4R3A4
swissprot - S4R3K1
swissprot - S4R3M1
swissprot - S4R459
Ensembl - ENSG00000112679
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q566R7ENSDARG00000039850Danio rerio
 DUSP22ENSGALG00000027397Gallus gallus
 Dusp22ENSMUSG00000069255Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUSP15 / Q9H1R2 / dual specificity phosphatase 15ENSG0000014959941
STYX / Q8WUJ0 / serine/threonine/tyrosine interacting proteinENSG0000019825227
DUPD1 / Q68J44 / dual specificity phosphatase and pro isomerase domain containing 1ENSG0000018871626
DUSP27 / Q5VZP5 / dual specificity phosphatase 27, atypicalENSG0000019884226
DUSP14 / O95147 / dual specificity phosphatase 14ENSG0000027602325
DUSP18 / Q8NEJ0 / dual specificity phosphatase 18ENSG0000016706525
DUSP19 / Q8WTR2 / dual specificity phosphatase 19ENSG0000016299924
DUSP3 / P51452 / dual specificity phosphatase 3ENSG0000010886124
DUSP26 / Q9BV47 / dual specificity phosphatase 26ENSG0000013387824
DUSP13 / Q6B8I1 / Q9UII6 / dual specificity phosphatase 13ENSG0000007939323
DUSP12 / Q9UNI6 / dual specificity phosphatase 12ENSG0000008172122
DUSP21 / Q9H596 / dual specificity phosphatase 21ENSG0000018903721
DUSP28 / Q4G0W2 / dual specificity phosphatase 28ENSG0000018854221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR020417  Atypical dual specificity phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000188 inactivation of MAPK activity TAS
 biological_processGO:0002710 negative regulation of T cell mediated immunity IEA
 biological_processGO:0006470 protein dephosphorylation TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IEA
 biological_processGO:0050868 negative regulation of T cell activation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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