Manteia

ENSDARG00000060130

Danio rerio

Features

Gene ID:	ENSDARG00000060130

Biological name :	dusp3b

Synonyms :	dual specificity phosphatase 3b / dusp3b

Possible biological names infered from orthology :	dual specificity phosphatase 3 / Dual specificity protein phosphatase 3 / DUSP3 / P51452 / Q9D7X3

Species:	Danio rerio

Chr. number:	3
Strand:	1
Band:
Gene start:	34683096
Gene end:	34688277

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSDARP00000078867 NCBI entrez gene - 568344 See in Manteia. swissprot - B3DHB2 ZFIN ID - ZDB-GENE-030616-38 Ensembl - ENSDARG00000060130

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
DUSP3	ENSGALG00000035369	Gallus gallus
DUSP3	ENSG00000108861	Homo sapiens
Dusp3	ENSMUSG00000003518	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
dusp3a / dual specificity phosphatase 3a / DUSP3* / Q9D7X3* / P51452* / dual specificity phosphatase 3* / Dual specificity protein phosphatase 3 *	ENSDARG00000061255	63
DUSP26 / dual specificity phosphatase 26 / Q9BV47*	ENSDARG00000103752	41
zgc:153981	ENSDARG00000069529	40
si:ch211-121a2.2 / DUPD1* / Q68J44* / Q8BK84* / Dual specificity phosphatase DUPD1 * / dual specificity phosphatase and pro isomerase domain containing 1*	ENSDARG00000039682	40
dusp13a / dual specificity phosphatase 13a / Q9UII6* / DUSP13* / Q6B8I1* / Q9QYJ7* / Q6B8I0* / dual specificity phosphatase 13* / Dual specificity protein phosphatase 13 isoform A *	ENSDARG00000061498	39
si:ch211-223p8.8	ENSDARG00000092650	37
CABZ01097761.1	ENSDARG00000116119	35
si:dkey-194e6.2 / DUPD1* / Q68J44* / Q8BK84* / Dual specificity phosphatase DUPD1 * / dual specificity phosphatase and pro isomerase domain containing 1*	ENSDARG00000095001	32
si:dkeyp-27c8.1 / DUPD1 (1 of many) / DUPD1* / Q68J44* / Q8BK84* / Dual specificity phosphatase DUPD1 * / dual specificity phosphatase and pro isomerase domain containing 1*	ENSDARG00000067808	32
si:dkeyp-27c8.1 / DUPD1* / Q68J44* / Q8BK84* / Dual specificity phosphatase DUPD1 * / dual specificity phosphatase and pro isomerase domain containing 1*	ENSDARG00000092956	32
dusp19a / dual specificity phosphatase 19a / DUSP19* / Q8WTR2* / dual specificity phosphatase 19*	ENSDARG00000040490	28
dusp19b / dual specificity phosphatase 19b / DUSP19* / Q8WTR2* / dual specificity phosphatase 19*	ENSDARG00000045200	28
styx / serine/threonine/tyrosine interacting protein / Q60969* / Q8WUJ0* / Gm14698* / predicted gene 14698* / serine/threonine/tyrosine interaction protein*	ENSDARG00000057699	28
zgc:153044 / DUSP18* / DUSP21* / Q8NEJ0* / Q9H596* / dual specificity phosphatase 21* / dual specificity phosphatase 18*	ENSDARG00000067564	27
dusp14 / dual specificity phosphatase 14 / O95147* / Q9JLY7* / Dual specificity protein phosphatase 14 *	ENSDARG00000057625	27
BX005321.1 / DUPD1* / Q68J44* / dual specificity phosphatase and pro isomerase domain containing 1*	ENSDARG00000112213	25
Q566R7 / dusp22b / dual specificity phosphatase 22b / Q9NRW4* / DUSP22* / Q99N11* / dual specificity phosphatase 22* / Dual specificity protein phosphatase 22 *	ENSDARG00000039850	24
Q1LWL2 / dusp22a / dual specificity phosphatase 22a	ENSDARG00000056396	24
si:dkey-24f15.2	ENSDARG00000094665	24
dusp12 / dual specificity phosphatase 12 / Q9D0T2* / Q9UNI6* / Mus musculus dual specificity phosphatase 12 (Dusp12), transcript variant 3, mRNA.*	ENSDARG00000076330	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR000340	Dual specificity phosphatase, catalytic domain
IPR000387	Tyrosine specific protein phosphatases domain
IPR016130	Protein-tyrosine phosphatase, active site
IPR020405	Atypical dual specificity phosphatase, subfamily A
IPR020417	Atypical dual specificity phosphatase
IPR020422	Dual specificity protein phosphatase domain
IPR024950	Dual specificity phosphatase
IPR029021	Protein-tyrosine phosphatase-like

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000188	inactivation of MAPK activity	IEA
biological_process	GO:0006470	protein dephosphorylation	IEA
biological_process	GO:0016311	dephosphorylation	IEA
biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	IEA
biological_process	GO:0045931	positive regulation of mitotic cell cycle	IBA
biological_process	GO:0046329	negative regulation of JNK cascade	IBA
biological_process	GO:0050860	negative regulation of T cell receptor signaling pathway	IBA
biological_process	GO:0050868	negative regulation of T cell activation	IBA
biological_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IBA
cellular_component	GO:0005829	cytosol	IBA
molecular_function	GO:0004725	protein tyrosine phosphatase activity	IEA
molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEA
molecular_function	GO:0016791	phosphatase activity	IEA
molecular_function	GO:0033549	MAP kinase phosphatase activity	IBA

Pathways (from Reactome)

Pathway description

ERKs are inactivated

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000027552	mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*	/ reaction
ENSDARG00000023110	mapk7 / mitogen-activated protein kinase 7 / Q13164* / Q9WVS8*	/ reaction
ENSDARG00000070573	mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*	/ reaction

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr