ENSDARG00000070573


Danio rerio

Features
Gene ID: ENSDARG00000070573
  
Biological name :mapk3
  
Synonyms : mapk3 / mitogen-activated protein kinase 3
  
Possible biological names infered from orthology : P27361 / Q63844
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 26211974
Gene end: 26222381
  
Corresponding Affymetrix probe sets: Dr.10552.1.S1_at (Zebrafish Array)   Dr.16331.2.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000094521
NCBI entrez gene - 399480     See in Manteia.
RefSeq - NM_201507
RefSeq Peptide - NP_958915
swissprot - Q7ZVK8
ZFIN ID - ZDB-GENE-040121-1
Ensembl - ENSDARG00000070573
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAPK3ENSG00000102882Homo sapiens
 Mapk3ENSMUSG00000063065Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*ENSDARG0000002755278
mapk7 / mitogen-activated protein kinase 7 / Q13164* / Q9WVS8*ENSDARG0000002311046
mapk6 / mitogen-activated protein kinase 6 / Q16659* / Q61532*ENSDARG0000003210340
nlk2 / nemo-like kinase, type 2 / NLK* / O54949* / Q9UBE8* / nemo like kinase* / Serine/threonine-protein kinase NLK *ENSDARG0000002879340
mapk4 / mitogen-activated protein kinase 4 / P31152* / Q6P5G0*ENSDARG0000011058136
mapk15 / mitogen-activated protein kinase 15 / Q80Y86* / Q8TD08*ENSDARG0000010082235
nlk1 / nemo-like kinase, type 1ENSDARG0000000656635


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008349  Mitogen-activated protein (MAP) kinase, ERK1/2
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0001654 eye development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IMP
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0071310 cellular response to organic substance IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005769 early endosome IBA
 cellular_componentGO:0005770 late endosome IBA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005856 cytoskeleton IBA
 cellular_componentGO:0005901 caveola IBA
 cellular_componentGO:0005925 focal adhesion IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
MAPK3 (ERK1) activation
RAF-independent MAPK1/3 activation
ISG15 antiviral mechanism
Spry regulation of FGF signaling
Golgi Cisternae Pericentriolar Stack Reorganization
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
RNA Polymerase I Promoter Opening
Signal attenuation
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
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 ZFA:0000029 hindbrain hindbrain axon decreased length , abnormal
hindbrain axon disorganized , abnormal
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 ZFA:0000038 margin margin disorganized , abnormal
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 ZFA:0000107 eye eye morphology , abnormal
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 ZFA:0000109 forebrain forebrain axon decreased size , abnormal
forebrain axon disorganized , abnormal
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 ZFA:0000135 notochord notochord deformed , abnormal
notochord increased width , abnormal
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 ZFA:0000155 somite somite morphology , abnormal
somite U-shaped , abnormal
somite deformed , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism pigmented , abnormal
whole organism decreased length , abnormal
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 ZFA:0001114 head head deformed , abnormal
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 ZFA:0001115 trunk trunk decreased length , abnormal
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 ZFA:0001117 post-vent region post-vent region curved , abnormal
post-vent region decreased length , abnormal
post-vent region shape , abnormal
post-vent region deformed , abnormal
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 ZFA:0001655 pericardial cavity pericardial cavity edematous , abnormal
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 ZFA:0009090 pigment cell pigment cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006609 map2k2a / mitogen-activated protein kinase kinase 2a / P36507* / MAP2K2* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein kinase...  / reaction / complex
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / complex / reaction
 ENSDARG00000019307 dusp5 / dual specificity phosphatase 5 / Q16690*  / reaction
 ENSDARG00000017661 braf / B-Raf proto-oncogene, serine/threonine kinase / P15056* / P28028* / Serine/threonine-protein kinase B-raf *  / complex / reaction
 ENSDARG00000013078 ywhaba / Q5PRD0 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a / YWHAB* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activat...  / reaction / complex
 ENSDARG00000026630 mark3b / MAP/microtubule affinity-regulating kinase 3b / MARK1* / MARK3* / P27448* / Q9P0L2* / Q8VHJ5* / Q03141* / Serine/threonine-protein kinase MARK1 * / microtubule affinity regulating ...  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / complex / reaction
 ENSDARG00000060012 f2r / coagulation factor II (thrombin) receptor / P25116* / P30558* / Proteinase-activated receptor 1 *  / reaction / complex
 ENSDARG00000060130 dusp3b / dual specificity phosphatase 3b / DUSP3* / Q9D7X3* / P51452* / dual specificity phosphatase 3* / Dual specificity protein phosphatase 3 *  / reaction
 ENSDARG00000044688 dusp4 / dual specificity phosphatase 4 / Q13115* / Q8BFV3* / Dual specificity protein phosphatase 4 *  / reaction
 ENSDARG00000061255 dusp3a / dual specificity phosphatase 3a / DUSP3* / Q9D7X3* / P51452* / dual specificity phosphatase 3* / Dual specificity protein phosphatase 3 *  / reaction
 ENSDARG00000069105 fgfr4 / fibroblast growth factor receptor 4 / P22455*  / reaction
 ENSDARG00000057075 lamtor3 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 / O88653* / Q9UHA4*  / reaction / complex
 ENSDARG00000011190 fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*  / reaction
 ENSDARG00000011027 fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*  / reaction
 ENSDARG00000102778 fgf17 / Q6SJP8 / fibroblast growth factor 17 / O60258* / P63075*  / reaction
 ENSDARG00000043962 fgf18b / fibroblast growth factor 18b / FGF18* / O89101* / O76093* / fibroblast growth factor 18*  / reaction
 ENSDARG00000007356 fgf20a / fibroblast growth factor 20a / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*  / reaction
 ENSDARG00000060551 rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / Q8C050* / ribosomal protein S6 kinase A5*  / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / reaction
 ENSDARG00000008818 hsf1 / heat shock transcription factor 1 / P38532* / Q00613* / heat shock factor 1*  / reaction
 ENSDARG00000079862 kl / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / reaction
 ENSDARG00000079771 pea15 / proliferation and apoptosis adaptor protein 15 / Q15121*  / reaction / complex
 ENSDARG00000035066 ubtf / upstream binding transcription factor, RNA polymerase I / P17480* / Q3USZ2* / P0CB47* / UBTFL1* / upstream binding transcription factor, RNA polymerase I-like 1*  / reaction
 ENSDARG00000030932 fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*  / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000011545 arrb2b / arrestin, beta 2b / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex / reaction
 ENSDARG00000039872 lamtor2 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 / Q9JHS3* / Q9Y2Q5* / Ragulator complex protein LAMTOR2 *  / complex / reaction
 ENSDARG00000076294 klb / klotho beta / Q86Z14* / Q99N32* / Beta-klotho *  / reaction
 ENSDARG00000086070 fgf20b / fibroblast growth factor 20b / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*  / reaction
 ENSDARG00000028469 rps6ka2 / ribosomal protein S6 kinase, polypeptide 2 / Q15349* / ribosomal protein S6 kinase A2*  / reaction
 ENSDARG00000059387 fgf7 / fibroblast growth factor 7 / P21781*  / reaction
 ENSDARG00000101540 fgf3 / P48802 / fibroblast growth factor 3 / P11487*  / reaction
 ENSDARG00000103980 ets2 / v-ets avian erythroblastosis virus E26 oncogene homolog 2 / ETS1* / P14921* / P27577* / Protein C-ets-1 * / ETS proto-oncogene 1, transcription factor*  / reaction
 ENSDARG00000075282 irs2b / insulin receptor substrate 2b / IRS2* / Irs3* / P81122* / Q9Y4H2* / insulin receptor substrate 2*  / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction / complex
 ENSDARG00000098663 fgf19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / reaction
 ENSDARG00000039215 arrb2a / arrestin, beta 2a / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / reaction
 ENSDARG00000054087 irs1 / insulin receptor substrate 1 / P35568*  / reaction
 ENSDARG00000004782 fgfr3 / fibroblast growth factor receptor 3 / P22607*  / reaction
 ENSDARG00000031683 fosab / v-fos FBJ murine osteosarcoma viral oncogene homolog Ab / FOS* / P01100* / P01101* / Proto-onco c-Fos * / Fos proto-oncogene, AP-1 transcription factor subunit*  / reaction
 ENSDARG00000100475 fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*  / reaction
 ENSDARG00000076510 fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*  / reaction
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction
 ENSDARG00000043241 arrb1 / arrestin, beta 1 / P49407*  / complex / reaction
 ENSDARG00000070914 dusp6 / dual specificity phosphatase 6 / Q16828* / Q9DBB1* / Dual specificity protein phosphatase 6 *  / reaction
 ENSDARG00000101413 dusp7 / dual specificity phosphatase 7 / Q16829*  / reaction
 ENSDARG00000098359 il17rd / interleukin 17 receptor D / Q8NFM7*  / complex / reaction






 

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