ENSDARG00000026630


Danio rerio

Features
Gene ID: ENSDARG00000026630
  
Biological name :mark3b
  
Synonyms : MAP/microtubule affinity-regulating kinase 3b / mark3b
  
Possible biological names infered from orthology : MAP/microtubule affinity-regulating kinase 3 / MARK1 / MARK3 / microtubule affinity regulating kinase 1 / microtubule affinity regulating kinase 3 / P27448 / Q03141 / Q8VHJ5 / Q9P0L2 / Serine/threonine-protein kinase MARK1
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 43792866
Gene end: 43917689
  
Corresponding Affymetrix probe sets: Dr.15872.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000008926
Ensembl peptide - ENSDARP00000127106
NCBI entrez gene - 767634     See in Manteia.
swissprot - A2CEF7
swissprot - U3JA41
ZFIN ID - ZDB-GENE-060929-80
Ensembl - ENSDARG00000026630
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MARK1ENSGALG00000009483Gallus gallus
 MARK3ENSGALG00000011505Gallus gallus
 MARK1ENSG00000116141Homo sapiens
 MARK3ENSG00000075413Homo sapiens
 Mark1ENSMUSG00000026620Mus musculus
 Mark3ENSMUSG00000007411Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mark3a / MAP/microtubule affinity-regulating kinase 3aENSDARG0000001934573
mark2b / MAP/microtubule affinity-regulating kinase 2b / MARK2* / Q7KZI7* / microtubule affinity regulating kinase 2*ENSDARG0000003245862
mark2a / MAP/microtubule affinity-regulating kinase 2a / MARK2* / Q7KZI7* / microtubule affinity regulating kinase 2*ENSDARG0000007990561
mark1 / MAP/microtubule affinity-regulating kinase 1ENSDARG0000010401458
MARK4 / si:dkey-31m14.7 / Q96L34* / Q8CIP4* / microtubule affinity regulating kinase 4* / MAP/microtubule affinity-regulating kinase 4 *ENSDARG0000002496658
mark4a / MAP/microtubule affinity-regulating kinase 4a / MARK4* / Q8CIP4* / Q96L34* / microtubule affinity regulating kinase 4* / MAP/microtubule affinity-regulating kinase 4 *ENSDARG0000002391457
sik2b / salt-inducible kinase 2b / SIK2* / Q9H0K1* / salt inducible kinase 2*ENSDARG0000006231529
sik1 / salt-inducible kinase 1 / SIK1B* / Q60670* / P57059* / salt inducible kinase 1B (putative)* / Serine/threonine-protein kinase SIK1 *ENSDARG0000005860629
snrka / SNF related kinase a / SNRK* / Q9NRH2* / SNF related kinase*ENSDARG0000007083228
sik2a / salt-inducible kinase 2a / SIK2* / Q9H0K1* / salt inducible kinase 2*ENSDARG0000007961828
sik3 / SIK family kinase 3ENSDARG0000008808327
snrkb / SNF related kinase bENSDARG0000001766522
si:ch211-22d5.2ENSDARG0000007903119
nim1k / NIM1 serine/threonine protein kinase / Q8BHI9* / Q8IY84* / Serine/threonine-protein kinase NIM1 *ENSDARG0000007408719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001772  Kinase associated domain 1 (KA1)
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR033628  Serine/threonine-protein kinase MARK3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006609 map2k2a / mitogen-activated protein kinase kinase 2a / P36507* / MAP2K2* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein kinase...  / complex / reaction
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction / complex
 ENSDARG00000017661 braf / B-Raf proto-oncogene, serine/threonine kinase / P15056* / P28028* / Serine/threonine-protein kinase B-raf *  / complex / reaction
 ENSDARG00000013078 ywhaba / Q5PRD0 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a / YWHAB* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activat...  / reaction / complex
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / complex / reaction
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction / complex






 

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