ENSMUSG00000007411


Mus musculus

Features
Gene ID: ENSMUSG00000007411
  
Biological name :Mark3
  
Synonyms : MAP/microtubule affinity-regulating kinase 3 / Mark3 / Q03141
  
Possible biological names infered from orthology : microtubule affinity regulating kinase 3 / P27448
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 111574523
Gene end: 111656221
  
Corresponding Affymetrix probe sets: 10398695 (MoGene1.0st)   1418316_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152483
Ensembl peptide - ENSMUSP00000152377
Ensembl peptide - ENSMUSP00000152727
Ensembl peptide - ENSMUSP00000152833
Ensembl peptide - ENSMUSP00000074757
Ensembl peptide - ENSMUSP00000082017
NCBI entrez gene - 17169     See in Manteia.
MGI - MGI:1341865
RefSeq - XM_011244007
RefSeq - XM_006515515
RefSeq - XM_006515517
RefSeq - XM_006515518
RefSeq - XM_006515519
RefSeq - XM_006515522
RefSeq - XM_011244006
RefSeq - NM_021516
RefSeq - NM_022801
RefSeq - XM_006515511
RefSeq - XM_006515512
RefSeq - XM_006515513
RefSeq - XM_006515514
RefSeq Peptide - NP_067491
RefSeq Peptide - NP_073712
swissprot - A0A1Y7VNZ6
swissprot - A0A1Y7VK86
swissprot - Q03141
swissprot - A0A1Y7VJB1
Ensembl - ENSMUSG00000007411
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mark3bENSDARG00000026630Danio rerio
 MARK3ENSGALG00000011505Gallus gallus
 MARK3ENSG00000075413Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mark1 / Q8VHJ5 / Serine/threonine-protein kinase MARK1 / Q9P0L2* / microtubule affinity regulating kinase 1*ENSMUSG0000002662074
Mark2 / microtubule affinity regulating kinase 2 / Q7KZI7*ENSMUSG0000002496966
Mark4 / Q8CIP4 / MAP/microtubule affinity-regulating kinase 4 / Q96L34* / microtubule affinity regulating kinase 4*ENSMUSG0000003039764
Sik3 / SIK family kinase 3ENSMUSG0000003413534
Sik1 / Q60670 / Serine/threonine-protein kinase SIK1 / SIK1B* / P57059* / salt inducible kinase 1* / salt inducible kinase 1B (putative)*ENSMUSG0000002404231
Sik2 / salt inducible kinase 2 / Q9H0K1*ENSMUSG0000003711230
Snrk / Q8VDU5 / Mus musculus SNF related kinase (Snrk), transcript variant 5, mRNA. / Q9NRH2* / SNF related kinase*ENSMUSG0000003814529
Nim1k / Q8BHI9 / Serine/threonine-protein kinase NIM1 / Q8IY84* / NIM1 serine/threonine protein kinase*ENSMUSG0000009593021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001772  Kinase associated domain 1 (KA1)
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR033628  Serine/threonine-protein kinase MARK3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0035331 negative regulation of hippo signaling ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

Allelic Composition: Mark2tm1Hpw/Mark2+,Mark3tm1Hpw/Mark3tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw,Mark3tm1Hpw/Mark3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

Allelic Composition: Mark2tm1Hpw/Mark2+,Mark3tm1Hpw/Mark3tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw,Mark3tm1Hpw/Mark3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0004185 abnormal adipocyte glucose uptake "anomaly in the ability of adipocytes to take in glucose" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator ""]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000004936 Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*  / complex / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / reaction / complex
 ENSMUSG00000018334 Ksr1 / Q61097 / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q8IVT5* / kinase suppressor of ras 1*  / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction / complex
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction / complex
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction / complex
 ENSMUSG00000035027 Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*  / complex / reaction
 ENSMUSG00000029458 Brap / Q99MP8 / BRCA1-associated protein / Q7Z569*  / complex / reaction






 

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