Manteia - Molecule gene

ENSMUSG00000029458

Mus musculus

Features

Gene ID:	ENSMUSG00000029458

Biological name :	Brap

Synonyms :	Brap / BRCA1-associated protein / Q99MP8

Possible biological names infered from orthology :	Q7Z569

Species:	Mus musculus

Chr. number:	5
Strand:	1
Band:	F
Gene start:	121660563
Gene end:	121687256

Corresponding Affymetrix probe sets:	10525296 (MoGene1.0st) 1416738_at (Mouse Genome 430 2.0 Array) 1416739_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000122536 Ensembl peptide - ENSMUSP00000143350 Ensembl peptide - ENSMUSP00000143043 Ensembl peptide - ENSMUSP00000031414 Ensembl peptide - ENSMUSP00000107395 NCBI entrez gene - 72399 See in Manteia. MGI - MGI:1919649 RefSeq - XM_006530469 RefSeq - NM_001289543 RefSeq - NM_001289544 RefSeq - NM_028227 RefSeq Peptide - NP_001276473 RefSeq Peptide - NP_001276472 RefSeq Peptide - NP_082503 swissprot - Q99MP8 swissprot - A0A0G2JFY1 swissprot - D6RG84 swissprot - A0A0G2JF68 Ensembl - ENSMUSG00000029458

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
brap	ENSDARG00000008560	Danio rerio
BRAP	ENSGALG00000004650	Gallus gallus
BRAP	ENSG00000089234	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001607	Zinc finger, UBP-type
IPR001841	Zinc finger, RING-type
IPR011422	BRCA1-associated 2
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR034932	BRAP2, RNA recognition motif
IPR035979	RNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	ISO
biological_process	GO:0007265	Ras protein signal transduction	ISO
biological_process	GO:0009968	negative regulation of signal transduction	ISO
biological_process	GO:0016567	protein ubiquitination	IEA
cellular_component	GO:0000151	ubiquitin ligase complex	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0031965	nuclear membrane	ISO
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0004842	ubiquitin-protein transferase activity	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008139	nuclear localization sequence binding	ISO
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0042802	identical protein binding	ISO
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0061630	ubiquitin protein ligase activity	ISO

Pathways (from Reactome)

Pathway description

Negative regulation of MAPK pathway

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000923	abnormal roof plate morphology	"malformation or absence of a transient group of neuroepithelial cells located at the dorsal midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Brap^tm1.1Yfng/Brap^tm1.1Yfng,Pafah1b1^tm1Awb/Pafah1b1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Brap^tm1.1Yfng/Brap^tm1.1Yfng,Pafah1b1^tm1Awb/Pafah1b1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0004046	abnormal mitosis	"anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Brap^tm1.1Yfng/Brap^tm1.1Yfng,Pafah1b1^tm1Awb/Pafah1b1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Brap^tm1.1Yfng/Brap^tm1.1Yfng Genetic Background: involves: C57BL/6 * FVB/N
MP:0006207	embryonic lethality during organogenesis	"death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Brap^tm1.1Yfng/Brap^tm1.1Yfng,Pafah1b1^tm1Awb/Pafah1b1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Brap^tm1.1Yfng/Brap^tm1.1Yfng Genetic Background: involves: C57BL/6 * FVB/N

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000018334	Ksr1 / Q61097 / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q8IVT5* / kinase suppressor of ras 1*	/ reaction / complex
ENSMUSG00000025499	Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*	/ reaction / complex
ENSMUSG00000030265	Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*	/ reaction / complex
ENSMUSG00000007411	Mark3 / Q03141 / MAP/microtubule affinity-regulating kinase 3 / P27448* / microtubule affinity regulating kinase 3*	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr