| MP:0000023 | abnormal ear distance/ position | "anomaly in the space between or the placement of the outer ears " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0000208 | decreased hematocrit | "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
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| MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Lrrc17tm1Nik/Lrrc17+,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0000219 | increased neutrophil count | "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0000220 | increased monocyte count | "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0000230 | abnormal blood pressure | "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hgstm1Tkh/Hgstm1Tkh
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000231 | hypertension | "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hgstm1Tkh/Hgstm1Tkh
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000240 | extramedullary hematopoiesis | "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0000245 | abnormal erythropoiesis | "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm1Mok/Kras+
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He
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| MP:0000275 | heart hyperplasia | "increased cell number in the heart" [J:18048] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
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Allelic Composition: Krastm1Mok/Kras+
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0000292 | distended pericardial sacs | "stretched outer parietal layer of the pericardium" [J:25248] |
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0000316 | cellular necrosis | "pathologic death of cells, usually from irreversible damage" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0000322 | increased granulocyte number | "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
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| MP:0000350 | abnormal cell proliferation | "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm1Bbd/Krastm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000351 | increased cell proliferation | "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
Allelic Composition: Krastm4Tyj/Krastm4Tyj
Genetic Background: B6.129S4-Krastm4Tyj
Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N
Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pggt1btm1Mbrg/Pggt1btm1Mbrg,Krastm4Tyj/Kras+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0000358 | abnormal cell content/ morphology | "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S
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| MP:0000420 | ruffled hair | "fuzzy, irregular appearance of the hair" [J:50844] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
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| MP:0000438 | abnormal skull morphology | "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm5(ASPSCR1/TFE3)Mrc/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000441 | wide skull | |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0000447 | flattened snout | |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0000477 | abnormal intestine morphology | "malformation of the digestive tube passing from the stomach to the anus" [J:48968] |
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Allelic Composition: Cntn1m1J/Cntn1m1J
Genetic Background: B6;C-Cntn1m1J/GrsrJ
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
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| MP:0000488 | abnormal intestinal epithelium morphology | "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0000495 | abnormal colon morphology | "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He
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| MP:0000592 | short tail | "reduced length of tail compared to control " [J:55583] |
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Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
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| MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0000600 | liver hypoplasia | "reduced size of liver due to decreased cell number " [J:57631] |
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Allelic Composition: Krastm1Mok/Krastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0000601 | small liver | "reduced size of the liver" [J:23170] |
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Allelic Composition: Krastm1Mok/Krastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0000603 | pale liver | "liver lacking normal coloration, often refers to bloodless condition" [J:18048] |
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Allelic Composition: Krastm1Mok/Krastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0000610 | cholestasis | "impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0000611 | jaundice | "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
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| MP:0000652 | enlarged sebaceous gland | "increased size of the sebum secreting glands of the hair shaft" [J:30249] |
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Allelic Composition: Tbx4tm1(cre)Tmj/Tbx4tm1(cre)Tmj
Genetic Background: Not Specified
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| MP:0000659 | prostate gland hyperplasia | "increased cell number in the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764] |
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Allelic Composition: Btkxid/?,Tg(IGH-Btk)1Witt/Tg(IGH-Btk)1Witt
Genetic Background: involves: BALB/c * C3H * C57BL/6 * CBA/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
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| MP:0000688 | lymphoid hyperplasia | "increased cell number in lymphatic tissues" [J:62478] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
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| MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
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| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Krastm4.1Bbd/Kras+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0000753 | paralysis | "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0000807 | abnormal hippocampus morphology | "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0000858 | altered metastatic potential | |
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Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000913 | abnormal brain development | "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840] |
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Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He
Allelic Composition: Krastm4Tyj/Kras+,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0000952 | abnormal CNS glia | "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0001126 | abnormal ovary morphology | "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg
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| MP:0001154 | seminiferous tubule degeneration | "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm4Tyj/Kras+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0001158 | abnormal prostate morphology | "mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764] |
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
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| MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
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Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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| MP:0001176 | abnormal lung development | "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
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| MP:0001179 | thicker alveolar septa | |
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Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
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| MP:0001188 | hyperpigmentation | "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311] |
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Allelic Composition: Agtpbp1pcd-2J/Agtpbp1pcd-2J
Genetic Background: SM/J
Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Krastm4Tyj/Kras+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129S4/SvJae * FVB
Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2a+,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Krastm4Tyj/Kras+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129S4/SvJae * FVB
Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Krastm4Tyj/Kras+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: B6J.Cg-Cdkn2atm2.1Nesh Krastm4Tyj Tg(Tyr-cre/ERT2)13Bos
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| MP:0001212 | skin lesions | "focal patches of inflammation on the skin" [J:30162] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac
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| MP:0001219 | thickened epidermis | "increase in the width of the epidermal cell layer in the skin" [J:65146] |
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Allelic Composition: Hprttm75(Ple143-lacZ)Ems/Y
Genetic Background: B6.Cg-Hprttm75(Ple143-lacZ)Ems/Mmjax
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| MP:0001222 | epidermal hyperplasia | "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Hprttm75(Ple143-lacZ)Ems/Y
Genetic Background: B6.Cg-Hprttm75(Ple143-lacZ)Ems/Mmjax
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| MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Gt(ROSA)26Sortm5(ASPSCR1/TFE3)Mrc/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001270 | distended abdomen | "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
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| MP:0001272 | increased metastatic potential | |
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Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm3Glo/Trp53+,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB * ICR
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/?
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Mir182)Dgk/Gt(ROSA)26Sortm1(CAG-Mir182)Dgk,Krastm4Tyj/Krastm4Tyj,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk
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| MP:0001273 | decreased metastatic potential | |
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Krastm4Tyj/Krastm4Tyj,Mir182tm1.1Dgk/Mir182tm1.1Dgk,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Krastm4Tyj,Mir182tm1.1Dgk/Mir182+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Rab11fip1tm1.1Jicn/Rab11fip1tm1.1Jicn,Tg(Pdx1-cre)6Tuv/0,Trp53tm2.1Tyj/Trp53+
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Epha2tm1Jrui/Epha2tm1Jrui,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm2.1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * FVB/N
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| MP:0001286 | abnormal eye development | "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840] |
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Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0001300 | ocular hypertelorism | "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0001347 | absent lacrimal glands | "missing the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Krastm4Tyj,Ugdhtm1.1Xzh/Ugdhtm1.1Xzh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J
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| MP:0001505 | hunched posture | "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+
Genetic Background: involves: 129S4/SvJae
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| MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4.1Tyj/Kras+,Spry2tm1Mrt/Spry2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Lrrc17tm1Nik/Lrrc17+,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0001601 | abnormal myelopoiesis | "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0001654 | hepatic necrosis | "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He
Allelic Composition: Krastm1Mok/Krastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0001716 | abnormal placental labyrinth | "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129S4/SvJae
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| MP:0001719 | absent vitelline blood vessels | "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129S4/SvJae
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| MP:0001721 | absent blood islands | "missing pools of blood in the yolk sac" [J:12623] |
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0001722 | pale yolk sac | "bloodless yolk sac" [J:62571] |
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129S4/SvJae
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| MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
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Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm4Tyj/Kras+,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129S4/SvJae
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pggt1btm1Mbrg/Pggt1btm1Mbrg,Krastm4Tyj/Kras+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
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| MP:0001750 | increased circulating follicle stimulating hormone level | "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm4Tyj/Kras+,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0001751 | increased circulating luteinizing hormone level | "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm4Tyj/Kras+,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
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| MP:0001787 | pericardial edema | "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] |
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Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0001846 | increased inflammatory response | "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Scgb1a1-cre)1Kkw/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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| MP:0001869 | pancreas inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Klrk1tm1.1Bpol/Klrk1tm1.1Bpol
Genetic Background: C57BL/6-Klrk1tm1.1Bpol
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| MP:0001879 | abnormal lymphatic vessel morphology | "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Flt4tm1.1Ichi/Flt4+
Genetic Background: B6.Cg-Flt4tm1.1Ichi
Allelic Composition: Flt4tm1.1Ichi/Flt4+,Krastm1Mok/Kras+
Genetic Background: involves: 129S/SvEv * C57BL/6
Allelic Composition: Flt4tm1.1Ichi/Flt4+,Krastm1Mok/Kras+,Tg(HRAS)2Jic/0
Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
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| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0001944 | abnormal pancreas morphology | "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Klrk1tm1.1Bpol/Klrk1tm1.1Bpol
Genetic Background: C57BL/6-Klrk1tm1.1Bpol
Allelic Composition: Krastm4Tyj/Kras+,Pdpk1tm1Mlw/Pdpk1tm1Mlw,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae
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| MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre/ERT)1Ipc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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| MP:0002014 | papilloma | "benign epithelial tumor" [J:47225] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Allelic Composition: Cdk4tm1.1Bbd/Cdk4+,Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
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| MP:0002018 | malignant tumors | "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427] |
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Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J
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| MP:0002019 | abnormal tumor incidence | "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
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| MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/?
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
Allelic Composition: Braftm1Rima/Braf+,Krastm4Tyj/Kras+,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Pax7tm2.1(cre/ERT2)Fan/Pax7+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Myod1tm1.1(cre/ERT,TVA)Gcg/Myod1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Plcl1tm1.1Matk/Plcl1tm1.1Matk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002024 | T cell derived lymphoma | "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm3Tyj/Krastm3Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm3Tyj/Kras+,Mir21atm1.1Eno/Mir21atm1.1Eno
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
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| MP:0002027 | lung adenocarcinoma | "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542] |
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Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre/ERT)1Ipc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Krastm4Tyj/Kras+,Tg(Scgb1a1-cre)1Kkw/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Map2k7tm1.1Twad/Map2k7tm1.2Twad
Genetic Background: B6.Cg-Krastm4Tyj Map2k7tm1.1Twad/Map2k7tm1.2Twad
Allelic Composition: Krastm4Tyj/Kras+,Map2k7tm1.1Twad/Map2k7tm1.2Twad,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm
Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj
Allelic Composition: Krastm5Tyj/Kras+,Trp53tm1.1Dgk/Trp53tm1.1Dgk
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(RAC1*)Jkis/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Lejo/Trp53tm1Lejo
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1.1(cre/ERT2)Ptch/Sftpc+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Rnf7Gt(XE423)Byg/Rnf7+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB/N * SJL
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
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| MP:0002030 | neurofibrosarcoma | "malignant neoplasm of fibrous tissue of the nervous system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542] |
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd
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| MP:0002032 | sarcoma | "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Allelic Composition: Cdk4tm1.1Bbd/Cdk4+,Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm5Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm5Tyj/Kras+,Trp53tm1.1Dgk/Trp53tm1.1Dgk
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Pax7tm2.1(cre/ERT2)Fan/Pax7+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Myod1tm1.1(cre/ERT,TVA)Gcg/Myod1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002038 | carcinoma | "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm3Glo/Trp53+,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB * ICR
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * FVB * ICR
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm3Glo,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * FVB * ICR
Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
Allelic Composition: Apctm2Rak/Apctm2Rak,Krastm4Tyj/Kras+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6J * SJL
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| MP:0002041 | pituitary adenoma | "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042] |
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Allelic Composition: Cdk4tm1.1Bbd/Cdk4+,Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
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| MP:0002044 | colonic adenoma | "benign tumors of the large intestine" [J:38772] |
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Allelic Composition: Apctm2Rak/Apctm2Rak,Krastm4Tyj/Kras+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6J * SJL
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| MP:0002048 | lung adenoma | "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Fntbtm1Bbd/Fntbtm1Bbd,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Allelic Composition: Cdk4tm1.1Bbd/Cdk4+,Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre/ERT)1Ipc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1(MYC/ERT2)Gev,Krastm4Tyj/Krastm4Tyj
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krasa/Krasa
Genetic Background: multiple strains
Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj
Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1(cre/ERT2)Blh/Sftpc+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Krastm3Tyj/Kras+,Mir21atm1.1Eno/Mir21atm1.1Eno
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
Allelic Composition: Braftm2Cpri/Braf+,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1.1(cre/ERT2)Ptch/Sftpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1.1(cre/ERT2)Ptch/Sftpc+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB
Allelic Composition: Krastm4Tyj/Kras+,Mapkapk2tm1.1Yaff/Mapkapk2tm1.1Yaff,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Mapkapk2tm1.1Yaff/Mapkapk2tm1.1Yaff
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Rnf7Gt(XE423)Byg/Rnf7+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm1.1Hbji/Krastm1.1Hbji,Trp53tm5Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S4/SvJae
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| MP:0002051 | skin papilloma | "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB * ICR
Allelic Composition: Krastm3Tyj/Krastm3Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Fgfr3tm4Cxd/Fgfr3+,Krastm4Tyj/Kras+,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
Allelic Composition: Krastm4Tyj/Kras+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J
Allelic Composition: Krastm4Tyj/Kras+,Tg(IVL-cre/ERT2)1Blpn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Y
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Usp9x+
Genetic Background: involves: 129S4/SvJae * FVB/N
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| MP:0002052 | decreased tumor incidence | "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Atoh1tm1(cre)Gan/Atoh1tm1(cre)Gan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Cdk2tm2Sgo/Cdk2tm2Sgo,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm3Tyj/Kras+,Tg(CAG-Mir21,-EGFP)#Eno/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6
Allelic Composition: Krastm3Tyj/Kras+,Mir21atm1.1Eno/Mir21atm1.1Eno
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm3Tyj/Krastm3Tyj,Mir301tm1Yoli/Mir301tm1Yoli
Genetic Background: involves: 129S4/SvJae * C57BL/6J
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| MP:0002053 | decreased incidence of induced tumors | "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886] |
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Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J
Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre/ERT)1Ipc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Ccne1tm1Jro/?,Krastm3Tyj/?
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)
Allelic Composition: Krastm4Tyj/Kras+,Tg(Scgb1a1-cre)1Kkw/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm3Tyj/Krastm3Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Apctm2.1Cip/Apc+,Krastm4Tyj/Kras+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm1Bbd/Kras+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Lrrc17tm1Nik/Lrrc17+,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Cdk2tm2Sgo/Cdk2tm2Sgo,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cdk6tm1Bbd/Cdk6tm1Bbd,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd
Allelic Composition: Brca2tm1Brn/Brca2tm1Cam,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm3Tyj/Trp53+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2+,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2+,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Map2k7tm1.1Twad/Map2k7tm1.2Twad
Genetic Background: B6.Cg-Krastm4Tyj Map2k7tm1.1Twad/Map2k7tm1.2Twad
Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Fgfr3tm4Cxd/Fgfr3+,Krastm4Tyj/Kras+,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm
Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj
Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1(cre/ERT2)Blh/Sftpc+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Krastm3Tyj/Kras+,Tg(CAG-Mir21,-EGFP)#Eno/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm4Tyj/Kras+,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(sb13)Tuv/Gt(ROSA)26Sor+,Tg(Pdx1-cre)6Tuv/0,TgTn(sb-T2/Onc)#Dla/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Y
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Usp9x+
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Gfi1tm5.1(GFI1*)Tmo/Gfi1tm5.1(GFI1*)Tmo,Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gfi1tm5.1(GFI1*)Tmo/Gfi1+,Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gfi1tm6.1(GFI1)Tmo/Gfi1tm6.1(GFI1)Tmo,Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1.1(cre/ERT2)Ptch/Sftpc+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB
Allelic Composition: Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/?
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
Allelic Composition: Krastm1Bbd/Kras+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Mapk1tm1.1Hed/Mapk1tm1.1Hed
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Mapk1tm1.1Hed/Mapk1tm1.1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Map2k1tm1Chrn/Map2k1tm1Chrn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Map2k2tm1Chrn/Map2k2tm1Chrn
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Krastm1Bbd/Kras+,Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Rnf7Gt(XE423)Byg/Rnf7tm1.1Ysun
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Rnf7Gt(XE423)Byg/Rnf7+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Krastm4.1Bbd/Kras+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB/N * SJL
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Krastm4Tyj/Kras+,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * FVB/N
Allelic Composition: Krastm3Tyj/Krastm3Tyj,Mir301tm1Yoli/Mir301tm1Yoli
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk
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| MP:0002123 | abnormal hematopoiesis | "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
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| MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm5(ASPSCR1/TFE3)Mrc/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002138 | abnormal liver/biliary system morphology | "structural abnormality or aberrant development of any of the tissues of the liver or biliary system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Smarcb1tm1Sho/Smarcb1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dag1tm1Kcam/Dag1tm2Kcam,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa
Allelic Composition: Krastm1Mok/Kras+
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Krastm1Mok/Krastm1Mok,Tg(HRAS)7Mok/0
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Allelic Composition: Hrastm1Mok/Hrastm1Mok,Krastm1Mok/Krastm1Mok,Nrastm1Mok/Nrastm1Mok,Tg(HRAS)7Mok/0
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Allelic Composition: Krastm2(Kras)Rdl/Krastm2(Kras)Rdl
Genetic Background: either: 129/Sv or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
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| MP:0002182 | abnormal astrocyte morphology | "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0002188 | small heart | "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044] |
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Allelic Composition: Krastm1Mok/Kras+
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0002192 | hydrops fetalis | "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0002264 | abnormal bronchus morphology | "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002267 | abnormal bronchiole morphology | "any structural anomaly of the conducting airway of the lungs found terminal to the bronchi. These structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0] |
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Allelic Composition: Krastm4Tyj/Kras+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002270 | abnormal alveoli morphology | "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1(cre/ERT2)Blh/Sftpc+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0002396 | abnormal hematopoietic system morphology/development | "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm5(ASPSCR1/TFE3)Mrc/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002429 | abnormal blood cell morphology/development | "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Lrrc17tm1Nik/Lrrc17+,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
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| MP:0002447 | abnormal erythrocyte morphology | "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
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| MP:0002493 | increased IgG | "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mks1krc/Mks1krc
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
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| MP:0002494 | increased IgM | "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mks1krc/Mks1krc
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
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| MP:0002606 | increased basophil count | "higher than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0002640 | reticulocytosis | "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0002641 | anisopoikilocytosis | "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0002652 | thin myocardial wall | "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm1Mok/Krastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0002732 | trichoepithelioma | "benign hair follicle tumors that lack mature hair follicles, derived from basal cells of the hair follicles enclosing small keratin cysts" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
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| MP:0002745 | abnormal atrioventricular valve morphology | "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0002795 | dilated cardiomyopathy | "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hgstm1Tkh/Hgstm1Tkh
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002877 | abnormal melanocyte morphology | "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Krastm4Tyj/Kras+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129S4/SvJae * FVB
Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2a+,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Krastm4Tyj/Kras+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129S4/SvJae * FVB
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| MP:0002957 | intestinal adenocarcinoma | "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm2.1Cip/Apc+,Krastm4Tyj/Kras+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
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| MP:0003077 | abnormal cell cycle | "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266] |
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Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.1Mbrg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0003141 | cardiac fibrosis | "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hgstm1Tkh/Hgstm1Tkh
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0003179 | decreased platelet count | "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0003203 | increased neuron apoptosis | "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Krastm1Mok/Krastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0003253 | bile duct dilation | "abnormal distention of the bile ducts due to accumulation of fluid or bile" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Fbxw7tm1Iken/Fbxw7+,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA
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| MP:0003270 | intestinal obstruction | "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0003271 | abnormal duodenum morphology | "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0003277 | esophageal papilloma | "benign epithelial tumor of the esophagus" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0003331 | hepatocellular carcinoma | "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Yap1tm1.1Dupa/Yap1+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
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| MP:0003335 | exocrine pancreatic insufficiency | "reduced or absent function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
|
| MP:0003336 | pancreatic cysts | "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Krastm4Tyj,Trim33tm1Los/Trim33tm1Los,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Krastm4Tyj,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Krastm4Tyj,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Gne/Stk11tm1.1Gne
Genetic Background: involves: 129S4/SvJae * C57BL/6N
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| MP:0003357 | impaired granulosa cell differentiation | "atypical differentiation of the layer of small cells that forms the wall of an ovarian follicle" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43075] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm4Tyj/Kras+,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0003390 | lymphedema | "abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Flt4tm1.1Ichi/Flt4+,Krastm1Mok/Kras+
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0003394 | increased cardiac output | "greater than normal blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0003396 | abnormal embryonic hematopoiesis | "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans
" [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0003447 | reduced tumor growth/size | "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383] |
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm3Tyj/Kras+,Mir21atm1.1Eno/Mir21atm1.1Eno
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Ralatm1.2Cjm/Ralatm1.2Cjm,Ralbtm1.1Cjm/Ralbtm1.2Cjm
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: Eif4eGt(RRO036)Byg/Eif4e+,Krastm3Tyj/Kras+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm3Tyj/Krastm3Tyj,Mir301tm1Yoli/Mir301tm1Yoli
Genetic Background: involves: 129S4/SvJae * C57BL/6J
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| MP:0003448 | altered tumor morphology | "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm3Glo/Trp53+,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB * ICR
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
Allelic Composition: Krastm4Tyj/Kras+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae
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| MP:0003449 | abnormal intestinal goblet cells | "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0003450 | enlarged pancreas | "increase of the size of the pancreas compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tgcog/Tgcog
Genetic Background: involves: AKR/J * C57BL/6By
Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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| MP:0003567 | abnormal cardiomyocyte proliferation | "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm1Mok/Krastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0003607 | abnormal prostate physiology | "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
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| MP:0003667 | hemangiosarcoma | "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511] |
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Allelic Composition: Cdk4tm1.1Bbd/Cdk4+,Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
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| MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Eif4eGt(RRO036)Byg/Eif4e+,Krastm3Tyj/Kras+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0003717 | pallor | "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He
Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0003721 | increased tumor growth/size | "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Krastm5Tyj/Kras+,Trp53tm1.1Dgk/Trp53tm1.1Dgk
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Allelic Composition: Krastm3Tyj/Kras+,Tg(CAG-Mir21,-EGFP)#Eno/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(RAC1*)Jkis/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
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| MP:0003743 | abnormal facial morphology | "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0003750 | mouth tumor | "presence of abnormal rapidly proliferating cells in the mouth, usually in the form of a distinct mass" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(CAG-HPV16E6E7,-luc)#Mspi/0,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * FVB/N * FVB/NJ
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| MP:0003752 | oral papilloma | "benign epithelial tumor of the oral cavity" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Y
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Usp9x+
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(CAG-HPV16E6E7,-luc)#Mspi/0,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * FVB/N * FVB/NJ
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| MP:0003780 | lip tumor | "presence of abnormal rapidly proliferating cells in the lip, usually in the form of a distinct mass" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Krastm4Tyj/Kras+,Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
Allelic Composition: Krastm4Tyj/Kras+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J
Allelic Composition: Krastm4Tyj/Kras+,Tg(IVL-cre/ERT2)1Blpn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0003789 | osteosarcoma | "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0003887 | increased hepatocyte apoptosis | "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0003934 | abnormal pancreas development | "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm1Mok/Krastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0004028 | chromosome breakage | "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Ccne1tm1Jro/?,Krastm3Tyj/?
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)
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| MP:0004201 | fetal growth retardation | "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0004207 | squamous cell carcinoma | "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm3Glo,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * FVB * ICR
Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
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| MP:0004215 | abnormal myocardial fiber physiology | "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0004229 | abnormal embryonic erythropoiesis | "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0004230 | abnormal embryonic erythrocyte morphology | "structural anomaly of the embryonic blood cells that carry oxygen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0004261 | abnormal embryonic neuroepithelium morphology | "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He
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| MP:0004390 | abnormal bronchoalveolar duct junctions | "any structural anomaly of the branch point connecting the respiratory bronchioles to the alveolar ducts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0004499 | increased incidence of chemically-induced tumors | "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm3Glo/Trp53+,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB * ICR
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm3Glo,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * FVB * ICR
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| MP:0004502 | decreased incidence of chemically-induced tumors | "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * FVB * ICR
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| MP:0004564 | enlarged myocardial fiber | "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hgstm1Tkh/Hgstm1Tkh
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004809 | increased hematopoietic stem cell number | "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0004839 | bile duct hyperplasia | "overdevelopment or increased size of the bile ducts, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fbxw7tm1Iken/Fbxw7+,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA
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| MP:0004842 | abnormal large intestine crypts of Lieberkuhn morphology | "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0004868 | endometrial carcinoma | "malignant neoplasm arising from the endometrial tissue" [RGD:Rat Genome Database submission] |
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6J
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| MP:0004882 | enlarged lung | "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
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| MP:0004937 | dilated heart | "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0004973 | increased regulatory T cell number | "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005011 | increased eosinophil count | "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0005014 | increased B cell number | "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm
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| MP:0005015 | increased T cell number | "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm
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| MP:0005016 | decreased lymphocyte number | "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
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| MP:0005048 | thrombosis | "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0005097 | polychromatophilia | "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0005119 | decreased circulating thyroid-stimulating hormone level | "less than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk
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| MP:0005140 | decreased cardiac muscle contractility | "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hgstm1Tkh/Hgstm1Tkh
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005150 | cachexia | "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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| MP:0005181 | decreased circulating estradiol level | "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm4Tyj/Kras+,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0005185 | decreased circulating progesterone level | "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm4Tyj/Kras+,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0005220 | abnormal exocrine pancreas morphology | "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
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| MP:0005266 | abnormal metabolism | "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Krastm4Tyj,Trim33tm1Los/Trim33tm1Los,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2
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| MP:0005324 | ascites | "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J
Allelic Composition: Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
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| MP:0005355 | enlarged thyroid gland | "increased size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85158, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk
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| MP:0005425 | increased macrophage count | "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418] |
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0005426 | tachypnea | "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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| MP:0005435 | hemoperitoneum | "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
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| MP:0005470 | increased thyroxine level | "greater than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk
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| MP:0005562 | decreased mean corpuscular hemoglobin | "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0005599 | increased cardiac muscle contractility | "greater than the normal ability of the heart muscle to shorten or to develop increased tension
" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0005630 | increased lung weight | "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission] |
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
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| MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0006143 | increased diastolic blood pressure | "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hgstm1Tkh/Hgstm1Tkh
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0006144 | increased systolic blood pressure | "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hgstm1Tkh/Hgstm1Tkh
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0006262 | testis tumor | "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm4Tyj/Kras+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0006321 | increased myocardial fiber number | "increased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0006382 | abnormal lung epithelium morphology | "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.1Att/Siva1tm1.2Att
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.2Att/Siva1+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0006410 | abnormal common myeloid progenitor cell morphology | "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0008000 | ovary tumor | "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm4Tyj/Kras+,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0008008 | early cellular replicative senescence | "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0008014 | lung tumor | "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Krastm4.1Tyj/Kras+,Spry2tm1Mrt/Spry2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm2Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm3Tyj/Krastm3Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm3(CAG-luc)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1(MYC/ERT2)Gev,Krastm4Tyj/Krastm4Tyj
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
Allelic Composition: Krastm4Tyj/Kras+,Pik3r1tm1Lca/Pik3r1+,Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
Allelic Composition: Krastm4Tyj/Kras+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Map2k7tm1.1Twad/Map2k7tm1.2Twad
Genetic Background: B6.Cg-Krastm4Tyj Map2k7tm1.1Twad/Map2k7tm1.2Twad
Allelic Composition: Krastm4Tyj/Kras+,Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Map2k7tm1.1Twad/Map2k7tm1.2Twad,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm5Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm4Tyj/Kras+,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * FVB/N
Allelic Composition: Krastm3Tyj/Kras+,Tg(CAG-Mir21,-EGFP)#Eno/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Pms2tm2(cre)Lisk/Pms2tm2(cre)Lisk
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
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| MP:0008018 | facial tumor | "presence of abnormal, rapidly proliferating cells on the face usually in the form of a distinct mass " [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J
Allelic Composition: Krastm4Tyj/Kras+,Tg(IVL-cre/ERT2)1Blpn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0008058 | abnormal DNA repair | "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281] |
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Allelic Composition: Krastm4Tyj/Kras+,Map2k7tm1.1Twad/Map2k7tm1.2Twad
Genetic Background: B6.Cg-Krastm4Tyj Map2k7tm1.1Twad/Map2k7tm1.2Twad
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| MP:0008079 | decreased CD8-positive T cell number | "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0008249 | abnormal common lymphocyte progenitor cell morphology | "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0008250 | abnormal myeloid leukocyte morphology | "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766] |
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm
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| MP:0008412 | increased cellular sensitivity to oxidative stress | "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Eif4eGt(RRO036)Byg/Eif4e+,Krastm3Tyj/Kras+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0008476 | increased spleen red pulp amount | "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
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| MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0008567 | decreased interferon-gamma secretion | "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0008714 | lung carcinoma | "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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| MP:0008716 | lung non-small cell carcinoma | "a heterogeneous aggregate of at least three distinct histological types of lung cancer" [MESH:C04.557.470.200.300] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cdk6tm1Bbd/Cdk6tm1Bbd,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm3Tyj/Kras+,Tg(CAG-Mir21,-EGFP)#Eno/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Lejo/Trp53tm1Lejo
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm1Bbd/Kras+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Mapk1tm1.1Hed/Mapk1tm1.1Hed
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Map2k1tm1Chrn/Map2k1tm1Chrn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Map2k2tm1Chrn/Map2k2tm1Chrn
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Pdpk1tm1Mlw/Pdpk1tm1Mlw,Tg(Cela1-cre/ERT)1Dam/0
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Tg(Cela1-cre/ERT)1Dam/0
Genetic Background: involves: 129S4/SvJae
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| MP:0008717 | lung squamous cell carcinoma | "a lung carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
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| MP:0008718 | lung large cell carcinoma | "a bronchogenic tumor of undifferentiated (anaplastic) cells of large size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
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| MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm1Bbd/Kras+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0008780 | pancreatic acinar cell carcinoma | "presence of an adenocarcinoma arising from cells of the pancreas that secrete digestive enzymes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm1Brn/Brca2tm1Cam,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0008803 | abnormal placental labyrinth vasculature morphology | "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129S4/SvJae
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| MP:0008866 | chromosomal instability | "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0008883 | abnormal enterocyte proliferation | "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0009043 | pancreas adenoma | "a benign epithelial neoplasm located in the pancreas" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
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| MP:0009108 | increased pancreas weight | "increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw
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| MP:0009110 | pancreas hyperplasia | "overdevelopment or increased size of the pancreas, usually due an increased number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Krastm4Tyj,Trim33tm1Los/Trim33tm1Los,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2
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| MP:0009143 | abnormal pancreatic duct morphology | "any structural anomaly of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667] |
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Allelic Composition: Cdk4tm1.1Bbd/Cdk4+,Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0009144 | dilated pancreatic duct | "an increase in volume of the luminal space of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667] |
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Allelic Composition: Krastm4Tyj/Krastm4Tyj,Trim33tm1Los/Trim33tm1Los,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2
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| MP:0009151 | pancreatic ductal adenocarcinoma | "adenocarcinoma that arises from the pancraetic ducts" [MESH:C04.557.470.200.025.232.750] |
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Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/?
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MUC1)79.24Gend/0
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw Tg(MUC1)79.24Gend
Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw
Allelic Composition: Brca2tm1Brn/Brca2tm1Cam,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm3Tyj/Trp53+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2+,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2+,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(sb13)Tuv/Gt(ROSA)26Sor+,Tg(Pdx1-cre)6Tuv/0,TgTn(sb-T2/Onc)#Dla/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Krastm1Bbd/Krastm1Bbd,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/?
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Raf1tm2Bacc/Raf1tm2Bacc,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm2Tyj,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Tg(CAG-Bgeo,-tsA58T)T26Ichi/0,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm1Gev/Trp53tm1Gev
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0009152 | pancreatic intraepithelial neoplasia | "noninvasive pancreatic duct lesions that affect smaller caliber ducts and do not involve the main pancreatic duct" [PMID:11342768] |
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Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Krastm4Tyj,Tg(Cela1-cre/ERT2)1Stof/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Krastm4Tyj/Krastm4Tyj,Bhlha15tm3(cre/ERT2)Skz/Bhlha15+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Krastm4Tyj,Tg(Cela1-cre/ERT)1Dam/0
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Krastm4Tyj/Krastm4Tyj,Tg(Cela1-cre/ERT)1Dam/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Krastm4Tyj/Krastm4Tyj,Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Krastm4Tyj,Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MUC1)79.24Gend/0
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw Tg(MUC1)79.24Gend
Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw
Allelic Composition: Krastm4Tyj/Krastm4Tyj,Trim33tm1Los/Trim33tm1Los,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Krastm4Tyj,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Krastm4Tyj,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(sb13)Tuv/Gt(ROSA)26Sor+,Tg(Pdx1-cre)6Tuv/0,TgTn(sb-T2/Onc)#Dla/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Y
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Usp9x+
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(CAG-Bgeo,-tsA58T)T26Ichi/0,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0009153 | pancreas tumor | "tumors or cancer of the pancreas" [MESH:C04.588.274.761] |
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MUC1)79.24Gend/0
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw Tg(MUC1)79.24Gend
Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw
Allelic Composition: Krastm4Tyj/Krastm4Tyj,Trim33tm1Los/Trim33tm1Los,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Krastm4Tyj,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(sb13)Tuv/Gt(ROSA)26Sor+,Tg(Pdx1-cre)6Tuv/0,TgTn(sb-T2/Onc)#Dla/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Y
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Usp9x+
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Cela1-cre/ERT)1Dam/0
Genetic Background: involves: 129S4/SvJae
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| MP:0009164 | exocrine pancreas atrophy | "wasting of the acinar gland portion of the pancreas that secretes digestive enzymes resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
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| MP:0009171 | enlarged pancreatic islets | "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414] |
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Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J
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| MP:0009216 | abnormal peritoneum morphology | "any structural abnormality of the serous sac, consisting of mesothelium and a thin external layer of irregular connective tissue, that lines the abdominopelvic cavity and covers most of the viscera contained therein; it forms two sacs: the peritoneal (or greater) sac and the omental bursa (lesser sac) connected by the omental foramen" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg
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| MP:0009219 | prostate intraepithelial neoplasia | "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Btkxid/?,Tg(IGH-Btk)1Witt/Tg(IGH-Btk)1Witt
Genetic Background: involves: BALB/c * C3H * C57BL/6 * CBA/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
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| MP:0009220 | prostate adenocarcinoma | "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Btkxid/?,Tg(IGH-Btk)1Witt/Tg(IGH-Btk)1Witt
Genetic Background: involves: BALB/c * C3H * C57BL/6 * CBA/N
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
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| MP:0009221 | uterus adenomyosis | "a benign invasion of myometrium by endometrial tissue" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0009254 | disorganized pancreatic islets | "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Krastm4Tyj,Trim33tm1Los/Trim33tm1Los,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2
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| MP:0009278 | abnormal bone marrow cell physiology | "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0009308 | adenocarcinoma | "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm2Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1(cre/ERT2)Blh/Sftpc+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Apctm2Rak/Apctm2Rak,Krastm4Tyj/Kras+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6J * SJL
Allelic Composition: Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N
Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Krastm4Tyj/Kras+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0009320 | lymphoblastic lymphoma | "diffuse lymphoma with supradiaphragmatic distribution and T lymphocytes having convoluted nuclei" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
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| MP:0009336 | increased splenocyte proliferation | "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0009343 | dilated gall bladder | "abnormal distention of the gall bladder due to accumulation of fluid or bile" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0009523 | submandibular gland hyperplasia | "overdevelopment or increased size of either of the large major salivary glands situated beneath the mandible, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ
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| MP:0009535 | abnormal skin sebaceous gland morphology | "any structural anomaly of the holocrine glands of the dermis that secrete sebum into the hair follicles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Krastm4Tyj/Kras+,Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0009550 | urinary bladder carcinoma | "a malignant neoplasm of the urinary bladder, arising from epithelial cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Krastm4Tyj/Kras+,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * FVB/N
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| MP:0009704 | skin squamous cell carcinoma | "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * CD-1
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
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| MP:0009759 | abnormal hair follicle bulge | "an anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen)" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0009794 | sebaceous gland hyperplasia | "overdevelopment and increased size of the sebum secreting glands of the hair shaft, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0009797 | abnormal mismatch repair | "any functional anomaly in the system that promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination" [GO:0006298] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Pms2tm2(cre)Lisk/Pms2tm2(cre)Lisk
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0009828 | delayed tumor appearance | "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: Krastm1Bbd/Krastm1Bbd,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0010020 | spleen vascular congestion | "obstruction of the normal flux of blood within the blood vessel network of the spleen" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0010267 | decreased lung tumor incidence | "less than the expected number of neoplams in the lung, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo
Allelic Composition: Krasb/Krasb
Genetic Background: multiple strains
Allelic Composition: Krastm4Tyj/Kras+,Pik3r1tm1Lca/Pik3r1tm1Lca,Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
Allelic Composition: Krastm3Tyj/Kras+,Mir21atm1.1Eno/Mir21atm1.1Eno
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Rnf7Gt(XE423)Byg/Rnf7tm1.1Ysun
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.1Att/Siva1tm1.2Att
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.2Att/Siva1+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Eif4eGt(RRO036)Byg/Eif4e+,Krastm3Tyj/Kras+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm3Tyj/Krastm3Tyj,Mir301tm1Yoli/Mir301tm1Yoli
Genetic Background: involves: 129S4/SvJae * C57BL/6J
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| MP:0010268 | decreased lymphoma incidence | "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm3Tyj/Krastm3Tyj,Mir301tm1Yoli/Mir301tm1Yoli
Genetic Background: involves: 129S4/SvJae * C57BL/6J
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| MP:0010273 | increased classified tumor incidence | "greater than the expected number of tumors with a specific classification type in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd
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| MP:0010274 | increased organ/body region tumor incidence | "greater than the expected number of tumors originating in a specific body region or organ in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trp53tm4Att/Trp53tm4Att,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Apctm2Rak/Apctm2Rak,Krastm4Tyj/Kras+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6J * SJL
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| MP:0010275 | increased melanoma incidence | "greater than the expected number of malignant neoplasms, derived from melanocytes and occuring in pigmented tissues, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Krastm4Tyj/Kras+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129S4/SvJae * FVB
Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2a+,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Krastm4Tyj/Kras+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129S4/SvJae * FVB
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| MP:0010279 | increased gastrointestinal tumor incidence | "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac
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| MP:0010283 | decreased classified tumor incidence | "less than the expected number of tumors with a specific classification type in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm1Bbd/Kras+,Mapk1tm1.1Hed/Mapk1tm1.1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm1Bbd/Kras+,Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Krastm1Bbd/Kras+,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0010285 | decreased skin tumor incidence | "less than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm3Tyj/Krastm3Tyj,Mir301tm1Yoli/Mir301tm1Yoli
Genetic Background: involves: 129S4/SvJae * C57BL/6J
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| MP:0010296 | increased hemolymphoid system tumor incidence | "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
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| MP:0010300 | increased skin tumor incidence | "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac
Allelic Composition: Krastm4Tyj/Kras+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J
Allelic Composition: Krastm4Tyj/Kras+,Tg(IVL-cre/ERT2)1Blpn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
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| MP:0010301 | increased stomach tumor incidence | "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
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| MP:0010306 | increased hamartoma incidence | "greater than the expected number of benign focal malformations in a specific population in a given time period; results from faulty development of an organ, and is composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element normally present at that site" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
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| MP:0010308 | decreased tumor latency | "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Brca1tm1Thl/Brca1tm3.1Thl,Krastm4Tyj/Kras+,Trp53tm1Thl/Trp53tm1Thl,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Thl/Trp53tm1Thl,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * FVB/N
Allelic Composition: Brca1tm1Thl/Brca1tm1Thl,Krastm4Tyj/Kras+,Trp53tm1Thl/Trp53tm1Thl,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca1tm1Thl/Brca1tm2.1Thl,Krastm4Tyj/Kras+,Trp53tm1Thl/Trp53tm1Thl,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0010309 | increased mesothelioma incidence | "greater than the expected number of neoplasms derived from the lining cells of the pleura and peritoneum, in a specific population in a given time period; is composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
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| MP:0010314 | increased neurofibroma incidence | "greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; proliferation is disordered and includes portions of nerve fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd
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| MP:0010315 | increased cholangiocarcinoma incidence | "greater than the expected number of malignant adenocarcimomas arising in the intrahepatic bile duct epithelium, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA
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| MP:0010322 | increased cutaneous melanoma incidence | "greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the skin, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Krastm4Tyj/Kras+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: B6J.Cg-Cdkn2atm2.1Nesh Krastm4Tyj Tg(Tyr-cre/ERT2)13Bos
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| MP:0010346 | increased thyroid carcinioma incidence | "greater than the expected number of a malignant epithelial neoplasms of the thyroid gland, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk
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| MP:0010349 | increased teratocarcinoma incidence | "greater than the expected number of a mixed germ cell neoplasm contaning elements of embryonal carcinoma and teratoma, occurring in a specific population in a given time period" [MPATH:321] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0010357 | increased prostate gland tumor incidence | "greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm1Bbd/Kras+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0010363 | increased fibrosarcoma incidence | "greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
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| MP:0010367 | increased spindle cell carcinoma incidence | "greater than the expected number of a highly malignant variant of squamous cell carcinoma, occurring in a specific population in a given time period; spindle cell carcinoma shows biphasic proliferation of conventional SCC component and malignant spindle shape cells with sarcomatous appearance" [PMID:19040765] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm3Glo,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * FVB * ICR
Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Krastm4Tyj/Kras+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129S4/SvJae * FVB
Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2a+,Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
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| MP:0010373 | myeloid hyperplasia | "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Gfi1tm5.1(GFI1*)Tmo/Gfi1tm5.1(GFI1*)Tmo,Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gfi1tm5.1(GFI1*)Tmo/Gfi1+,Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gfi1tm6.1(GFI1)Tmo/Gfi1tm6.1(GFI1)Tmo,Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0010383 | increased adenoma incidence | "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035] |
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Allelic Composition: Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cdk6tm1Bbd/Cdk6tm1Bbd,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
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| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0010588 | conotruncal ridge hyperplasia | "overdevelopment or increased size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0010594 | thick aortic valve | "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0010668 | abnormal hepatic portal vein morphology | "any structural anomaly of the wide short vein formed from the confluence of the superior mesenteric, inferior mesenteric and splenic veins, and then divides into the right and left branches which ramify with the liver; the hepatic portal vein carries venous blood from the GI tract, spleen and pancreas to the liver" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0010769 | abnormal survival | "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Epha2tm1Jrui/Epha2tm1Jrui,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm2.1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * FVB/N
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| MP:0010810 | increased type II pneumocyte number | "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632] |
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Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1.1(cre/ERT2)Ptch/Sftpc+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB
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| MP:0010856 | dilated respiratory conducting tubes | "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0010910 | bronchiolar epithelial hyperplasia | "increased size, often due to increased epithelial cell number, of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
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| MP:0010943 | abnormal bronchus epithelium morphology | "any structural anomaly of the epithelial layer of the bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129S4/SvJae
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| MP:0010945 | lung epithelium hyperplasia | "overdevelopment or increased size, usually due an increased number of cells in the epithelial layer of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm3Tyj/Kras+,Mir21atm1.1Eno/Mir21atm1.1Eno
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+
Genetic Background: involves: 129S4/SvJae
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| MP:0011024 | abnormal branching involved in lung morphogenesis | "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0011028 | impaired branching involved in bronchus morphogenesis | |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Krastm4Tyj/Kras+,Spry2tm1.1Mrt/Spry2tm1.1Mrt,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N
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| MP:0011032 | impaired branching involved in terminal bronchiole morphogenesis | |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Allelic Composition: Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Tg(CAG-Bgeo,-tsA58T)T26Ichi/0,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
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| MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: 129S2.129(Cg)-Krastm4.1Bbd
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: 129S2.129(Cg)-Krastm4.1Bbd
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Krastm1Mok/Krastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Krastm3Bbd/Krastm3Bbd
Genetic Background: B6.129-Krastm3Bbd
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He
Allelic Composition: Krastm1Bbd/Krastm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Hrastm1Mok/Hrastm1Mok,Krastm1Mok/Krastm1Mok
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
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| MP:0011102 | partial embryonic lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0011205 | excessive folding of visceral yolk sac | "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493] |
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0011285 | increased circulating erythropoietin level | "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0011400 | complete lethality | "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2] |
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac
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| MP:0011702 | abnormal fibroblast proliferation | "anomaly in the ability of the a fibroblast cell population to undergo expansion by cell division" [MGI:csmith] |
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Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre/ERT)1Ipc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0011703 | increased fibroblast proliferation | "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith] |
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Allelic Composition: Braftm2Cpri/Braf+,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm1.1Hbji/Krastm1.1Hbji,Trp53tm5Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S4/SvJae
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| MP:0011861 | increased cranium height | "increase in the rostral-caudal distance between the cranial base and the upper domelike portion of the skull" [MGI:mnk] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0011862 | decreased cranium length | "having an decreased dorsal-to-ventral distance of the cranium" [MGI:mnk] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0012080 | chylous ascites | "the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms" [MGI:csmith] |
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Allelic Composition: Flt4tm1.1Ichi/Flt4+
Genetic Background: B6.Cg-Flt4tm1.1Ichi
Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nras+
Genetic Background: B6.129S-Nrastm1Mok Krastm1Mok
Allelic Composition: Flt4tm1.1Ichi/Flt4+,Krastm1Mok/Kras+
Genetic Background: involves: 129S/SvEv * C57BL/6
Allelic Composition: Flt4tm1.1Ichi/Flt4+,Krastm1Mok/Kras+,Tg(HRAS)2Jic/0
Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Allelic Composition: Hrastm1Mok/Hrastm1Mok,Krastm1Mok/Kras+
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Allelic Composition: Hrastm1Mok/Hrastm1Mok,Krastm1Mok/Kras+,Nrastm1Mok/Nras+
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
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| MP:0012411 | increased granulosa cell tumor incidence | "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [http://orcid.org/0000-0001-5208-3432] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm4Tyj/Kras+,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm4Tyj/Kras+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0012431 | increased lymphoma incidence | "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith] |
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Allelic Composition: Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Krastm2Tyj/Kras+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
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| MP:0012433 | decreased ovarian tumor incidence | "less than the expected number of neoplams in the ovary occurring in a specific population in a given time period" [MGI:csmith] |
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
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| MP:0012546 | triangular face | "a face whose lower half becomes relatively thin, approaching an appearance of a triangle with a tip facing downwards; usually associated with a prominent forehead and micrognathia" [MGI:anna] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0012701 | increased embryonic neuroepithelium apoptosis | "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna] |
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Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He
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| MP:0013184 | hemorrhagic ascites | "the presence of bloody or blood-stained serous fluid, frequently resulting from metastatic carcinoma, in the peritoneal cavity" [MGI:anna] |
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Trp53tm2Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Tg(CAG-Bgeo,-tsA58T)T26Ichi/0,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0013220 | increased pancreas apoptosis | "increase in the number of cells of the pancreas undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0013221 | pancreatic acinar-to-ductal metaplasia | "a reprogramming event that induces transdifferentiation of pancreatic acinar cells to a duct-like phenotype in response to inflammatory injury; ADM is associated with an increased risk of exocrine pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma" [MGI:anna] |
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Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Tg(CAG-Bgeo,-tsA58T)T26Ichi/0,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0013331 | abnormal lacrimal gland development | "aberrant formation or incomplete differentiation of the paired almond-shaped glands, one for each eye, that secrete the aqueous layer of the tear film; each lacrimal gland develops through branching morphogenesis regulated by FGF signaling; at E12.5, the conjunctival epithelium at the temporal side of the mouse eyes invades the Fgf10-expressing mesenchyme to form the initial lacrimal gland bud; the bud elongates posteriorly until E15.5 when secondary branching begins to establish the complex tubuloalveolar structure; this eventually gives rise to the mature lacrimal gland composed of numerous ducts, acini and connective tissue" [MGI:Anna, PMID:22745308] |
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Allelic Composition: Krastm4Tyj/Krastm4Tyj,Ugdhtm1.1Xzh/Ugdhtm1.1Xzh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J
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| MP:0013443 | Harderian gland hyperplasia | "overdevelopment or increased size, usually due to an increased number of cells, of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane" [MGI:Anna] |
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Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre/ERT)1Ipc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0013504 | increased embryonic tissue cell apoptosis | "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129S4/SvJae
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| MP:0013663 | increased myeloid cell number | "greater than the expected number of cells of the myeloid lineage" [CL:0000763] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0013696 | increased granulocyte monocyte progenitor cell number | "increase in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251] |
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Allelic Composition: Krastm4.1Bbd/Krastm4.1Bbd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0013733 | squamous metaplasia of bulbourethral gland | "a benign non-cancerous transformation of the bulbourethral glandular epithelium into stratified squamous epithelium; keratinization may be present" [MGI:Anna, PMID:19117991] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm1Bbd/Kras+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0013735 | squamous metaplasia of urethral gland | "a benign non-cancerous transformation of the urethral glandular epithelium into stratified squamous epithelium; keratinization may be present" [MGI:Anna, PMID:19117991] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Krastm1Bbd/Kras+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0013795 | abnormal colon goblet cell morphology | "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481] |
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Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae
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| MP:0020190 | abnormal lung adenoma incidence | "an anomaly in the expected number of a benign epithelial neoplasm with a glandular organization arising in the lung, occurring in a specific population in a given time period" [GOC:NV] |
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Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.1Att/Siva1tm1.2Att
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.2Att/Siva1+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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