ENSMUSG00000026821


Mus musculus

Features
Gene ID: ENSMUSG00000026821
  
Biological name :Ralgds
  
Synonyms : Q03385 / Ralgds / ral guanine nucleotide dissociation stimulator
  
Possible biological names infered from orthology : AL162417.1 / Q12967
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 28513125
Gene end: 28553081
  
Corresponding Affymetrix probe sets: 10470564 (MoGene1.0st)   1460634_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115092
Ensembl peptide - ENSMUSP00000109526
Ensembl peptide - ENSMUSP00000116215
Ensembl peptide - ENSMUSP00000118966
Ensembl peptide - ENSMUSP00000028170
Ensembl peptide - ENSMUSP00000097812
NCBI entrez gene - 19730     See in Manteia.
MGI - MGI:107485
RefSeq - XM_006497799
RefSeq - NM_001145834
RefSeq - NM_001145835
RefSeq - NM_001145836
RefSeq - NM_009058
RefSeq - XM_006497796
RefSeq - XM_006497797
RefSeq - XM_006497798
RefSeq Peptide - NP_033084
RefSeq Peptide - NP_001139308
RefSeq Peptide - NP_001139307
RefSeq Peptide - NP_001139306
swissprot - Q03385
swissprot - Q3TWC1
swissprot - A2AK33
swissprot - B0R019
swissprot - F6QRS4
swissprot - B0R018
Ensembl - ENSMUSG00000026821
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-251j10.3ENSDARG00000042409Danio rerio
 ENSGALG00000003412Gallus gallus
 AL162417.1ENSG00000285245Homo sapiens
 Q12967ENSG00000160271Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgl1 / Q60695 / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA. / Q9NZL6* / ral guanine nucleotide dissociation stimulator like 1*ENSMUSG0000002648241
Rgl3 / Q3UYI5 / Ral guanine nucleotide dissociation stimulator-like 3 / Q3MIN7*ENSMUSG0000004014631
Rgl2 / Q61193 / Ral guanine nucleotide dissociation stimulator-like 2 / O15211*ENSMUSG0000004135431
P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*ENSMUSG0000003235618
Rasgrf2 / ras-specific guanine nucleotide-releasing factor 2 / O14827* / Ras protein specific guanine nucleotide releasing factor 2*ENSMUSG0000002170817
Sos2 / Q02384 / Son of sevenless homolog 2 / Q07890* / SOS Ras/Rho guanine nucleotide exchange factor 2*ENSMUSG0000003480117
Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*ENSMUSG0000002424116
Rapgef1 / Rap guanine nucleotide exchange factor (GEF) 1 / Q13905* / Rap guanine nucleotide exchange factor 1*ENSMUSG0000003984415
Q9ERD6 / Ralgps2 / Ral GEF with PH domain and SH3 binding motif 2 / Q86X27*ENSMUSG0000002659414
A2AR50 / Ralgps1 / Ras-specific guanine nucleotide-releasing factor RalGPS1 / Q5JS13* / Ral GEF with PH domain and SH3 binding motif 1*ENSMUSG0000003883114


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR015758  Ral guanine nucleotide dissociation stimulator
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005903 brush border ISO
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030695 GTPase regulator activity ISO


Pathways (from Reactome)
Pathway description
p38MAPK events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Gnaztm1Iah/Gnaz+
Genetic Background: C57BL/6JAnu-Gnaztm1Iah/Anu

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnaztm1Iah/Gnaz+
Genetic Background: C57BL/6JAnu-Gnaztm1Iah/Anu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction / complex
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / complex / reaction






 

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