ENSMUSG00000034801


Mus musculus

Features
Gene ID: ENSMUSG00000034801
  
Biological name :Sos2
  
Synonyms : Q02384 / Son of sevenless homolog 2 / Sos2
  
Possible biological names infered from orthology : Q07890 / SOS Ras/Rho guanine nucleotide exchange factor 2
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C2
Gene start: 69583762
Gene end: 69681852
  
Corresponding Affymetrix probe sets: 10400718 (MoGene1.0st)   1452281_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138793
Ensembl peptide - ENSMUSP00000044866
Ensembl peptide - ENSMUSP00000138589
NCBI entrez gene - 20663     See in Manteia.
MGI - MGI:98355
RefSeq - NM_001135559
RefSeq - XM_006515635
RefSeq Peptide - NP_001129031
swissprot - A0A0A0MQ87
swissprot - Q02384
swissprot - S4R2C4
Ensembl - ENSMUSG00000034801
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sos2ENSDARG00000060506Danio rerio
 SOS2ENSGALG00000012273Gallus gallus
 SOS2ENSG00000100485Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*ENSMUSG0000002424169
Rapgef1 / Rap guanine nucleotide exchange factor (GEF) 1 / Q13905* / Rap guanine nucleotide exchange factor 1*ENSMUSG0000003984417
Q03385 / Ralgds / ral guanine nucleotide dissociation stimulator / Q12967* / AL162417.1*ENSMUSG0000002682112
P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*ENSMUSG0000003235612
Rasgrf2 / ras-specific guanine nucleotide-releasing factor 2 / O14827* / Ras protein specific guanine nucleotide releasing factor 2*ENSMUSG0000002170811
Rgl1 / Q60695 / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA. / Q9NZL6* / ral guanine nucleotide dissociation stimulator like 1*ENSMUSG0000002648210
Rgl3 / Q3UYI5 / Ral guanine nucleotide dissociation stimulator-like 3 / Q3MIN7*ENSMUSG000000401469
A2AR50 / Ralgps1 / Ras-specific guanine nucleotide-releasing factor RalGPS1 / Q5JS13* / Ral GEF with PH domain and SH3 binding motif 1*ENSMUSG000000388318
Rgl2 / Q61193 / Ral guanine nucleotide dissociation stimulator-like 2 / O15211*ENSMUSG000000413548
Q9ERD6 / Ralgps2 / Ral GEF with PH domain and SH3 binding motif 2 / Q86X27*ENSMUSG000000265947


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001849  Pleckstrin homology domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR011993  PH-like domain superfamily
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IGI
 biological_processGO:0002260 lymphocyte homeostasis IGI
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0033081 regulation of T cell differentiation in thymus IGI
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0042129 regulation of T cell proliferation IGI
 biological_processGO:0051057 positive regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:2000973 regulation of pro-B cell differentiation IGI
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IMP
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Interleukin-15 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr