ENSMUSG00000034801


Mus musculus

Features
Gene ID: ENSMUSG00000034801
  
Biological name :Sos2
  
Synonyms : Q02384 / Son of sevenless homolog 2 / Sos2
  
Possible biological names infered from orthology : Q07890 / SOS Ras/Rho guanine nucleotide exchange factor 2
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C2
Gene start: 69583762
Gene end: 69681852
  
Corresponding Affymetrix probe sets: 10400718 (MoGene1.0st)   1452281_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138793
Ensembl peptide - ENSMUSP00000044866
Ensembl peptide - ENSMUSP00000138589
NCBI entrez gene - 20663     See in Manteia.
MGI - MGI:98355
RefSeq - NM_001135559
RefSeq - XM_006515635
RefSeq Peptide - NP_001129031
swissprot - A0A0A0MQ87
swissprot - Q02384
swissprot - S4R2C4
Ensembl - ENSMUSG00000034801
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sos2ENSDARG00000060506Danio rerio
 SOS2ENSGALG00000012273Gallus gallus
 SOS2ENSG00000100485Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*ENSMUSG0000002424169
Rapgef1 / Rap guanine nucleotide exchange factor (GEF) 1 / Q13905* / Rap guanine nucleotide exchange factor 1*ENSMUSG0000003984417
Q03385 / Ralgds / ral guanine nucleotide dissociation stimulator / Q12967* / AL162417.1*ENSMUSG0000002682112
P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*ENSMUSG0000003235612
Rasgrf2 / ras-specific guanine nucleotide-releasing factor 2 / O14827* / Ras protein specific guanine nucleotide releasing factor 2*ENSMUSG0000002170811
Rgl1 / Q60695 / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA. / Q9NZL6* / ral guanine nucleotide dissociation stimulator like 1*ENSMUSG0000002648210
Rgl3 / Q3UYI5 / Ral guanine nucleotide dissociation stimulator-like 3 / Q3MIN7*ENSMUSG000000401469
A2AR50 / Ralgps1 / Ras-specific guanine nucleotide-releasing factor RalGPS1 / Q5JS13* / Ral GEF with PH domain and SH3 binding motif 1*ENSMUSG000000388318
Rgl2 / Q61193 / Ral guanine nucleotide dissociation stimulator-like 2 / O15211*ENSMUSG000000413548
Q9ERD6 / Ralgps2 / Ral GEF with PH domain and SH3 binding motif 2 / Q86X27*ENSMUSG000000265947


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001849  Pleckstrin homology domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR011993  PH-like domain superfamily
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IGI
 biological_processGO:0002260 lymphocyte homeostasis IGI
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0033081 regulation of T cell differentiation in thymus IGI
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0042129 regulation of T cell proliferation IGI
 biological_processGO:0051057 positive regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:2000973 regulation of pro-B cell differentiation IGI
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IMP
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Interleukin-15 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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