ENSMUSG00000039844


Mus musculus

Features
Gene ID: ENSMUSG00000039844
  
Biological name :Rapgef1
  
Synonyms : Rapgef1 / Rap guanine nucleotide exchange factor (GEF) 1
  
Possible biological names infered from orthology : Q13905 / Rap guanine nucleotide exchange factor 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 29619720
Gene end: 29740978
  
Corresponding Affymetrix probe sets: 10470705 (MoGene1.0st)   1421146_at (Mouse Genome 430 2.0 Array)   1427006_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092703
Ensembl peptide - ENSMUSP00000117631
Ensembl peptide - ENSMUSP00000121615
Ensembl peptide - ENSMUSP00000088680
Ensembl peptide - ENSMUSP00000099936
NCBI entrez gene - 107746     See in Manteia.
MGI - MGI:104580
RefSeq - XM_006497592
RefSeq - XM_006497583
RefSeq - XM_006497584
RefSeq - XM_006497585
RefSeq - XM_006497586
RefSeq - XM_006497587
RefSeq - XM_006497588
RefSeq - XM_006497589
RefSeq - XM_006497590
RefSeq - NM_001039086
RefSeq - NM_001039087
RefSeq - NM_054050
RefSeq - XM_006497582
RefSeq Peptide - NP_001034176
RefSeq Peptide - NP_473391
RefSeq Peptide - NP_001034175
swissprot - E0CXV1
swissprot - F6ZDE5
swissprot - Q3UGX8
swissprot - Q3UHC1
swissprot - Q91ZZ2
Ensembl - ENSMUSG00000039844
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef1aENSDARG00000043593Danio rerio
 RAPGEF1ENSGALG00000003712Gallus gallus
 Q13905ENSG00000107263Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sos2 / Q02384 / Son of sevenless homolog 2 / Q07890* / SOS Ras/Rho guanine nucleotide exchange factor 2*ENSMUSG0000003480118
Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*ENSMUSG0000002424118
P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*ENSMUSG0000003235613
Rasgrf2 / ras-specific guanine nucleotide-releasing factor 2 / O14827* / Ras protein specific guanine nucleotide releasing factor 2*ENSMUSG0000002170812
Q03385 / Ralgds / ral guanine nucleotide dissociation stimulator / Q12967* / AL162417.1*ENSMUSG0000002682111
Rgl1 / Q60695 / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA. / Q9NZL6* / ral guanine nucleotide dissociation stimulator like 1*ENSMUSG000000264829
Rgl2 / Q61193 / Ral guanine nucleotide dissociation stimulator-like 2 / O15211*ENSMUSG000000413548
Rgl3 / Q3UYI5 / Ral guanine nucleotide dissociation stimulator-like 3 / Q3MIN7*ENSMUSG000000401468
A2AR50 / Ralgps1 / Ras-specific guanine nucleotide-releasing factor RalGPS1 / Q5JS13* / Ral GEF with PH domain and SH3 binding motif 1*ENSMUSG000000388317
Q9ERD6 / Ralgps2 / Ral GEF with PH domain and SH3 binding motif 2 / Q86X27*ENSMUSG000000265946


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0010976 positive regulation of neuron projection development ISO
 biological_processGO:0032486 Rap protein signal transduction ISO
 biological_processGO:0038180 nerve growth factor signaling pathway ISO
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IMP
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling IGI
 biological_processGO:0061028 establishment of endothelial barrier ISO
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IGI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071320 cellular response to cAMP ISO
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IGI
 biological_processGO:0098609 cell-cell adhesion IMP
 biological_processGO:1901888 regulation of cell junction assembly ISO
 biological_processGO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus ISO
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IMP
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017034 Rap guanyl-nucleotide exchange factor activity ISO


Pathways (from Reactome)
Pathway description
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Hoxc8tm1.1Rud/Hoxc8tm1.1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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