ENSG00000107263


Homo sapiens

Features
Gene ID: ENSG00000107263
  
Biological name :RAPGEF1
  
Synonyms : Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q34.13
Gene start: 131576770
Gene end: 131740074
  
Corresponding Affymetrix probe sets: 204543_at (Human Genome U133 Plus 2.0 Array)   225738_at (Human Genome U133 Plus 2.0 Array)   226389_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410640
Ensembl peptide - ENSP00000394296
Ensembl peptide - ENSP00000407210
Ensembl peptide - ENSP00000361263
Ensembl peptide - ENSP00000361264
Ensembl peptide - ENSP00000361269
NCBI entrez gene - 2889     See in Manteia.
OMIM - 600303
RefSeq - XM_017014639
RefSeq - XM_011518579
RefSeq - XM_017014633
RefSeq - XM_017014634
RefSeq - XM_017014635
RefSeq - XM_017014636
RefSeq - XM_017014637
RefSeq - XM_017014638
RefSeq - NM_001304275
RefSeq - NM_005312
RefSeq - NM_198679
RefSeq - XM_005272186
RefSeq - XM_005272191
RefSeq - XM_006717067
RefSeq - XM_006717072
RefSeq - XM_006717074
RefSeq - XM_011518569
RefSeq - XM_011518570
RefSeq - XM_011518571
RefSeq - XM_011518572
RefSeq - XM_011518573
RefSeq - XM_011518574
RefSeq - XM_011518575
RefSeq - XM_011518576
RefSeq - XM_011518577
RefSeq - XM_011518578
RefSeq Peptide - NP_001291204
RefSeq Peptide - NP_005303
RefSeq Peptide - NP_941372
swissprot - H0Y6R4
swissprot - H0Y4V2
swissprot - Q13905
swissprot - Q5JUE9
Ensembl - ENSG00000107263
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef1aENSDARG00000043593Danio rerio
 RAPGEF1ENSGALG00000003712Gallus gallus
 Rapgef1ENSMUSG00000039844Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOS2 / Q07890 / SOS Ras/Rho guanine nucleotide exchange factor 2ENSG0000010048521
SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1ENSG0000011590421
Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1ENSG0000005833515
O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2ENSG0000011331914
Q12967 / RALGDS / ral guanine nucleotide dissociation stimulatorENSG0000016027113
AL162417.1ENSG0000028524512
RGL3 / Q3MIN7 / ral guanine nucleotide dissociation stimulator like 3ENSG0000020551710
RGL1 / Q9NZL6 / ral guanine nucleotide dissociation stimulator like 1ENSG0000014334410
RGL4 / Q8IZJ4 / ral guanine nucleotide dissociation stimulator like 4ENSG000001594969
RGL2 / O15211 / ral guanine nucleotide dissociation stimulator like 2ENSG000002374419
Q5JS13 / RALGPS1 / Ral GEF with PH domain and SH3 binding motif 1ENSG000001368287
Q86X27 / RALGPS2 / Ral GEF with PH domain and SH3 binding motif 2ENSG000001161917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity TAS
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0032486 Rap protein signal transduction IMP
 biological_processGO:0038180 nerve growth factor signaling pathway IDA
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0061028 establishment of endothelial barrier IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1901888 regulation of cell junction assembly IMP
 biological_processGO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IDA
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017034 Rap guanyl-nucleotide exchange factor activity IMP
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000187266 EPOR / P19235 / erythropoietin receptor  / complex / reaction
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / reaction / complex
 ENSG00000130427 EPO / P01588 / erythropoietin  / complex / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / reaction / complex
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / reaction / complex
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / reaction / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000134259 NGF / P01138 / nerve growth factor  / reaction / complex
 ENSG00000050820 BCAR1 / P56945 / BCAR1, Cas family scaffolding protein  / complex / reaction
 ENSG00000185950 IRS2 / Q9Y4H2 / insulin receptor substrate 2  / reaction / complex
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / complex / reaction
 ENSG00000166225 FRS2 / Q8WU20 / fibroblast growth factor receptor substrate 2  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / reaction
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / reaction / complex
 ENSG00000134853 P16234 / PDGFRA / platelet derived growth factor receptor alpha  / complex / reaction
 ENSG00000113721 P09619 / PDGFRB / platelet derived growth factor receptor beta  / reaction / complex






 

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