ENSG00000237441


Homo sapiens

Features
Gene ID: ENSG00000237441
  
Biological name :RGL2
  
Synonyms : O15211 / ral guanine nucleotide dissociation stimulator like 2 / RGL2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.32
Gene start: 33291654
Gene end: 33299324
  
Corresponding Affymetrix probe sets: 209110_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392918
Ensembl peptide - ENSP00000420211
NCBI entrez gene - 5863     See in Manteia.
OMIM - 602306
RefSeq - XM_011514785
RefSeq - NM_001243738
RefSeq - NM_004761
RefSeq - XM_011514781
RefSeq Peptide - NP_001230667
RefSeq Peptide - NP_004752
swissprot - A2AB89
swissprot - O15211
swissprot - A0A024RCS9
Ensembl - ENSG00000237441
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-251j10.3ENSDARG00000042409Danio rerio
 ENSGALG00000003412Gallus gallus
 Rgl2ENSMUSG00000041354Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q12967 / RALGDS / ral guanine nucleotide dissociation stimulatorENSG0000016027137
AL162417.1ENSG0000028524536
RGL1 / Q9NZL6 / ral guanine nucleotide dissociation stimulator like 1ENSG0000014334432
RGL3 / Q3MIN7 / ral guanine nucleotide dissociation stimulator like 3ENSG0000020551732
RGL4 / Q8IZJ4 / ral guanine nucleotide dissociation stimulator like 4ENSG0000015949616
SOS2 / Q07890 / SOS Ras/Rho guanine nucleotide exchange factor 2ENSG0000010048515
SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1ENSG0000011590415
O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2ENSG0000011331914
Q86X27 / RALGPS2 / Ral GEF with PH domain and SH3 binding motif 2ENSG0000011619114
Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1ENSG0000005833514
Q5JS13 / RALGPS1 / Ral GEF with PH domain and SH3 binding motif 1ENSG0000013682814
Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1ENSG0000010726313


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR030749  Ral guanine nucleotide dissociation stimulator-like 2
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction NAS
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0032485 regulation of Ral protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity NAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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