ENSDARG00000042409


Danio rerio

Features
Gene ID: ENSDARG00000042409
  
Biological name :si:ch211-251j10.3
  
Synonyms : si:ch211-251j10.3
  
Possible biological names infered from orthology : AL162417.1 / O15211 / Q03385 / Q12967 / Q61193 / Q8IZJ4 / RALGDS / ral guanine nucleotide dissociation stimulator / ral guanine nucleotide dissociation stimulator like 2 / ral guanine nucleotide dissociation stimulator like 4 / RGL2 / RGL4
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 30949968
Gene end: 30979494
  
Corresponding Affymetrix probe sets: Dr.24179.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000118941
NCBI entrez gene - 799483     See in Manteia.
RefSeq - NM_001123317
RefSeq Peptide - NP_001116789
swissprot - B0S750
ZFIN ID - ZDB-GENE-081105-110
Ensembl - ENSDARG00000042409
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000003412Gallus gallus
 AL162417.1ENSG00000285245Homo sapiens
 Q12967ENSG00000160271Homo sapiens
 RGL2ENSG00000237441Homo sapiens
 RGL4ENSG00000159496Homo sapiens
 Q03385ENSMUSG00000026821Mus musculus
 Rgl2ENSMUSG00000041354Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rgl1 / ral guanine nucleotide dissociation stimulator-like 1 / Q60695* / Q9NZL6* / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA.*ENSDARG0000000598943
rgl3a / ral guanine nucleotide dissociation stimulator-like 3a / RGL3* / Q3MIN7* / Q3UYI5* / ral guanine nucleotide dissociation stimulator like 3*ENSDARG0000007121335
rgl2 / ral guanine nucleotide dissociation stimulator-like 2ENSDARG0000000772733
rasgrf2a / Ras protein-specific guanine nucleotide-releasing factor 2a / O14827* / RASGRF2* / Ras protein specific guanine nucleotide releasing factor 2*ENSDARG0000007505415
A2CEA7 / rasgrf2b / Ras protein-specific guanine nucleotide-releasing factor 2b / O14827* / RASGRF2* / ras-specific guanine nucleotide-releasing factor 2 * / Ras protein specific guanine nu...ENSDARG0000000281615
RASGRF1 / si:ch211-234p18.3 / P27671* / Q13972* / Ras protein specific guanine nucleotide releasing factor 1*ENSDARG0000007382415
sos2 / son of sevenless homolog 2 (Drosophila) / Q02384* / Q07890* / Son of sevenless homolog 2 * / SOS Ras/Rho guanine nucleotide exchange factor 2*ENSDARG0000006050615
B0UXH6 / ralgps1 / Ral GEF with PH domain and SH3 binding motif 1 / Q5JS13* / A2AR50* / Ras-specific guanine nucleotide-releasing factor RalGPS1 *ENSDARG0000006837014
ralgps2 / Ral GEF with PH domain and SH3 binding motif 2 / Q86X27* / Q9ERD6*ENSDARG0000002651913
rapgef1b / Rap guanine nucleotide exchange factor (GEF) 1bENSDARG0000001597113
rapgef1a / Rap guanine nucleotide exchange factor (GEF) 1a / Q13905* / RAPGEF1* / Rap guanine nucleotide exchange factor 1* / Rap guanine nucleotide exchange factor (GEF) 1*ENSDARG0000004359312
sos1 / son of sevenless homolog 1 (Drosophila) / Q07889* / Q62245* / Son of sevenless homolog 1 * / SOS Ras/Rac guanine nucleotide exchange factor 1*ENSDARG0000010050312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR015758  Ral guanine nucleotide dissociation stimulator
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
p38MAPK events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / complex / reaction
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / complex / reaction






 

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