ENSDARG00000002816


Danio rerio

Features
Gene ID: ENSDARG00000002816
  
Biological name :rasgrf2b
  
Synonyms : A2CEA7 / rasgrf2b / Ras protein-specific guanine nucleotide-releasing factor 2b
  
Possible biological names infered from orthology : O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2 / ras-specific guanine nucleotide-releasing factor 2
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 51443009
Gene end: 51581775
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000077785
NCBI entrez gene - 553520     See in Manteia.
RefSeq - NM_001128233
RefSeq Peptide - NP_001121705
swissprot - A2CEA7
ZFIN ID - ZDB-GENE-060504-1
Ensembl - ENSDARG00000002816
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RASGRF2ENSGALG00000015598Gallus gallus
 O14827ENSG00000113319Homo sapiens
 Rasgrf2ENSMUSG00000021708Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rasgrf2a / Ras protein-specific guanine nucleotide-releasing factor 2a / O14827* / RASGRF2* / Ras protein specific guanine nucleotide releasing factor 2*ENSDARG0000007505486
RASGRF1 / si:ch211-234p18.3 / P27671* / Q13972* / Ras protein specific guanine nucleotide releasing factor 1*ENSDARG0000007382467
sos2 / son of sevenless homolog 2 (Drosophila) / Q02384* / Q07890* / Son of sevenless homolog 2 * / SOS Ras/Rho guanine nucleotide exchange factor 2*ENSDARG0000006050612
rapgef1b / Rap guanine nucleotide exchange factor (GEF) 1bENSDARG0000001597112
rapgef1a / Rap guanine nucleotide exchange factor (GEF) 1a / Q13905* / RAPGEF1* / Rap guanine nucleotide exchange factor 1* / Rap guanine nucleotide exchange factor (GEF) 1*ENSDARG0000004359312
si:ch211-251j10.3 / RGL4* / RGL2* / Q61193* / Q8IZJ4* / RALGDS* / O15211* / Q03385* / Q12967* / AL162417.1* / ral guanine nucleotide dissociation stimulator* / ral guanine nucleotide dissoc...ENSDARG0000004240910
rgl3a / ral guanine nucleotide dissociation stimulator-like 3a / RGL3* / Q3MIN7* / Q3UYI5* / ral guanine nucleotide dissociation stimulator like 3*ENSDARG0000007121310
rgl1 / ral guanine nucleotide dissociation stimulator-like 1 / Q60695* / Q9NZL6* / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA.*ENSDARG000000059899
sos1 / son of sevenless homolog 1 (Drosophila) / Q07889* / Q62245* / Son of sevenless homolog 1 * / SOS Ras/Rac guanine nucleotide exchange factor 1*ENSDARG000001005038
rgl2 / ral guanine nucleotide dissociation stimulator-like 2ENSDARG000000077278
B0UXH6 / ralgps1 / Ral GEF with PH domain and SH3 binding motif 1 / Q5JS13* / A2AR50* / Ras-specific guanine nucleotide-releasing factor RalGPS1 *ENSDARG000000683707
ralgps2 / Ral GEF with PH domain and SH3 binding motif 2 / Q86X27* / Q9ERD6*ENSDARG000000265196


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000219  Dbl homology (DH) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001849  Pleckstrin homology domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR011993  PH-like domain superfamily
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR030744  Ras-specific guanine nucleotide-releasing factor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0046578 regulation of Ras protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000043010 Q6DEH3 / camk2d1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1 / CAMK2D* / Q13557* / Q6PHZ2* / calcium/calmodulin dependent protein kinase II delta* / Mus musculus c...  / complex / reaction
 ENSDARG00000077560 grin2cb / glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb / Q14957* / GRIN2C* / Q01098* / Glutamate receptor ionotropic, NMDA 2C * / glutamate ionotropic receptor NMDA type subunit 2C*  / reaction / complex
 ENSDARG00000002816 A2CEA7 / rasgrf2b / Ras protein-specific guanine nucleotide-releasing factor 2b / O14827* / RASGRF2* / ras-specific guanine nucleotide-releasing factor 2 * / Ras protein specific guanine nu...  / complex
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000100825 calm2a / calm2b / calm3a / Q6PI52 / calmodulin 2a (phosphorylase kinase, delta)  / reaction / complex
 ENSDARG00000086207 grin2da / glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a / Q03391* / GRIN2D* / O15399* / Glutamate receptor ionotropic, NMDA 2D * / glutamate ionotropic receptor NMDA type subunit 2D*  / reaction / complex
 ENSDARG00000030376 grin2bb / glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b / GRIN2B* / Q13224* / glutamate receptor, ionotropic, NMDA2B (epsilon 2)* / glutamate ionotropic recept...  / reaction / complex
 ENSDARG00000078149 grin2ca / glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca / Q14957* / GRIN2C* / Q01098* / Glutamate receptor ionotropic, NMDA 2C * / glutamate ionotropic receptor NMDA type subunit 2C*  / reaction / complex
 ENSDARG00000070543 grin2ab / glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b / Q12879* / GRIN2A* / P35436* / Glutamate receptor ionotropic, NMDA 2A * / glutamate ionotropic receptor NMDA type subunit 2A*  / reaction / complex
 ENSDARG00000075054 rasgrf2a / Ras protein-specific guanine nucleotide-releasing factor 2a / O14827* / RASGRF2* / Ras protein specific guanine nucleotide releasing factor 2*  / complex
 ENSDARG00000073824 RASGRF1 / si:ch211-234p18.3 / P27671* / Q13972* / Ras protein specific guanine nucleotide releasing factor 1*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr