ENSDARG00000043010


Danio rerio

Features
Gene ID: ENSDARG00000043010
  
Biological name :camk2d1
  
Synonyms : calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1 / camk2d1 / Q6DEH3
  
Possible biological names infered from orthology : calcium/calmodulin dependent protein kinase II delta / CAMK2D / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557 / Q6PHZ2
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 57725708
Gene end: 57880131
  
Corresponding Affymetrix probe sets: Dr.21774.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000119349
Ensembl peptide - ENSDARP00000131013
Ensembl peptide - ENSDARP00000056465
Ensembl peptide - ENSDARP00000113196
Ensembl peptide - ENSDARP00000118250
Ensembl peptide - ENSDARP00000118537
NCBI entrez gene - 445208     See in Manteia.
RefSeq - NM_001114708
RefSeq Peptide - NP_001108180
swissprot - F1QLM0
swissprot - F1RAL9
swissprot - Q6DEH3
swissprot - A0A0R4ID72
swissprot - F1QL80
ZFIN ID - ZDB-GENE-040801-121
Ensembl - ENSDARG00000043010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CAMK2DENSGALG00000041635Gallus gallus
 CAMK2DENSG00000145349Homo sapiens
 Camk2dENSMUSG00000053819Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
camk2d2 / calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2ENSDARG0000001427391
camk2b1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 / CAMK2B* / P28652* / Q13554* / calcium/calmodulin dependent protein kinase II beta* / Calcium/calmodulin-depend...ENSDARG0000001106587
camk2g2 / calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2 / CAMK2G* / Q13555* / Q923T9* / calcium/calmodulin dependent protein kinase II gamma* / Calcium/calmodulin-depe...ENSDARG0000005620685
camk2a / calcium/calmodulin-dependent protein kinase II alpha / Q9UQM7*ENSDARG0000005361785
camk2g1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 / CAMK2G* / Q13555* / Q923T9* / calcium/calmodulin dependent protein kinase II gamma* / Calcium/calmodulin-depe...ENSDARG0000007139584
camk2b2 / calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2 / CAMK2B* / P28652* / Q13554* / calcium/calmodulin dependent protein kinase II beta* / Calcium/calmodulin-depend...ENSDARG0000010008962
si:ch73-60h1.1ENSDARG0000007850431
camk1da / calcium/calmodulin-dependent protein kinase 1Da / CAMK1D* / Q8BW96* / Q8IU85* / calcium/calmodulin dependent protein kinase ID*ENSDARG0000007490528
camk1b / calcium/calmodulin-dependent protein kinase Ib / CAMK1* / Q14012* / Q91YS8* / calcium/calmodulin dependent protein kinase I*ENSDARG0000002947428
camk1ga / calcium/calmodulin-dependent protein kinase IGa / Q96NX5* / CAMK1G* / Q91VB2* / calcium/calmodulin dependent protein kinase IG* / Calcium/calmodulin-dependent protein kinase type 1G *ENSDARG0000004452628
camk4 / calcium/calmodulin-dependent protein kinase IV / Q16566*ENSDARG0000000537228
camk1a / calcium/calmodulin-dependent protein kinase Ia / CAMK1* / Q14012* / Q91YS8* / calcium/calmodulin dependent protein kinase I*ENSDARG0000006011628
camk1gb / calcium/calmodulin-dependent protein kinase IGb / Q96NX5* / CAMK1G* / Q91VB2* / calcium/calmodulin dependent protein kinase IG* / Calcium/calmodulin-dependent protein kinase type 1G *ENSDARG0000000878828
camk1db / calcium/calmodulin-dependent protein kinase 1Db / CAMK1D* / Q8BW96* / Q8IU85* / calcium/calmodulin dependent protein kinase ID*ENSDARG0000001744627
pnck / pregnancy up-regulated nonubiquitous CaM kinase / Q6P2M8* / Q9QYK9* / pregnancy upregulated non-ubiquitously expressed CaM kinase*ENSDARG0000004364825
camkvl / CaM kinase-like vesicle-associated, likeENSDARG0000005700024
camkva / CaM kinase-like vesicle-associated a / CAMKV* / Q8NCB2* / Q3UHL1* / CaM kinase like vesicle associated* / CaM kinase-like vesicle-associated protein *ENSDARG0000002796324
pskh1 / Q501V0 / protein serine kinase H1 / P11801* / Q91YA2*ENSDARG0000005671324
Q7SY49 / camkvb / CaM kinase-like vesicle-associated b / CAMKV* / Q8NCB2* / Q3UHL1* / CaM kinase like vesicle associated* / CaM kinase-like vesicle-associated protein *ENSDARG0000000514124
si:ch211-27e6.1 / PSKH2* / Q96QS6* / protein serine kinase H2*ENSDARG0000009989822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013543  Calcium/calmodulin-dependent protein kinase II, association-domain
 IPR017441  Protein kinase, ATP binding site
 IPR020636  Calcium/calmodulin-dependent/calcium-dependent protein kinase
 IPR032710  NTF2-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
HSF1-dependent transactivation
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF/MAP kinase cascade
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000037498 gria3b / glutamate receptor, ionotropic, AMPA 3b / GRIA3* / P42263* / Q9Z2W9* / glutamate ionotropic receptor AMPA type subunit 3* / Mus musculus glutamate receptor, ionotropic, AMPA3 (alph...  / reaction
 ENSDARG00000032737 gria3a / glutamate receptor, ionotropic, AMPA 3a / GRIA3* / P42263* / Q9Z2W9* / glutamate ionotropic receptor AMPA type subunit 3* / Mus musculus glutamate receptor, ionotropic, AMPA3 (alph...  / reaction
 ENSDARG00000032714 gria1b / glutamate receptor, ionotropic, AMPA 1b / GRIA1* / P23818* / P42261* / Glutamate receptor 1 * / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSDARG00000043010 Q6DEH3 / camk2d1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1 / CAMK2D* / Q13557* / Q6PHZ2* / calcium/calmodulin dependent protein kinase II delta* / Mus musculus c...  / reaction / complex
 ENSDARG00000008818 hsf1 / heat shock transcription factor 1 / P38532* / Q00613* / heat shock factor 1*  / reaction
 ENSDARG00000017661 braf / B-Raf proto-oncogene, serine/threonine kinase / P15056* / P28028* / Serine/threonine-protein kinase B-raf *  / reaction
 ENSDARG00000070543 grin2ab / glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b / Q12879* / GRIN2A* / P35436* / Glutamate receptor ionotropic, NMDA 2A * / glutamate ionotropic receptor NMDA type subunit 2A*  / complex / reaction
 ENSDARG00000078149 grin2ca / glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca / Q14957* / GRIN2C* / Q01098* / Glutamate receptor ionotropic, NMDA 2C * / glutamate ionotropic receptor NMDA type subunit 2C*  / complex / reaction
 ENSDARG00000086207 grin2da / glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a / Q03391* / GRIN2D* / O15399* / Glutamate receptor ionotropic, NMDA 2D * / glutamate ionotropic receptor NMDA type subunit 2D*  / complex / reaction
 ENSDARG00000073824 RASGRF1 / si:ch211-234p18.3 / P27671* / Q13972* / Ras protein specific guanine nucleotide releasing factor 1*  / complex / reaction
 ENSDARG00000006553 rras / RAS related / P10301* / P10833* / related RAS viral (r-ras) oncogene*  / reaction
 ENSDARG00000030376 grin2bb / glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b / GRIN2B* / Q13224* / glutamate receptor, ionotropic, NMDA2B (epsilon 2)* / glutamate ionotropic recept...  / complex / reaction
 ENSDARG00000077560 grin2cb / glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb / Q14957* / GRIN2C* / Q01098* / Glutamate receptor ionotropic, NMDA 2C * / glutamate ionotropic receptor NMDA type subunit 2C*  / complex / reaction
 ENSDARG00000100825 calm2a / calm2b / calm3a / Q6PI52 / calmodulin 2a (phosphorylase kinase, delta)  / reaction / complex
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000002816 A2CEA7 / rasgrf2b / Ras protein-specific guanine nucleotide-releasing factor 2b / O14827* / RASGRF2* / ras-specific guanine nucleotide-releasing factor 2 * / Ras protein specific guanine nu...  / complex / reaction
 ENSDARG00000075054 rasgrf2a / Ras protein-specific guanine nucleotide-releasing factor 2a / O14827* / RASGRF2* / Ras protein specific guanine nucleotide releasing factor 2*  / complex / reaction






 

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