ENSDARG00000053617


Danio rerio

Features
Gene ID: ENSDARG00000053617
  
Biological name :camk2a
  
Synonyms : calcium/calmodulin-dependent protein kinase II alpha / camk2a
  
Possible biological names infered from orthology : Calcium/calmodulin-dependent protein kinase type II subunit alpha / P11798 / Q9UQM7
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 43897128
Gene end: 43952958
  
Corresponding Affymetrix probe sets: Dr.14581.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000039570
Ensembl peptide - ENSDARP00000126124
NCBI entrez gene - 550436     See in Manteia.
RefSeq - NM_001017741
RefSeq Peptide - NP_001017741
swissprot - I3IT67
swissprot - E7F2G0
ZFIN ID - ZDB-GENE-051113-72
Ensembl - ENSDARG00000053617
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CAMK2AENSGALG00000005621Gallus gallus
 CAMK2AENSG00000070808Homo sapiens
 Camk2aENSMUSG00000024617Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
camk2d2 / calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2ENSDARG0000001427386
Q6DEH3 / camk2d1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1 / CAMK2D* / Q13557* / Q6PHZ2* / calcium/calmodulin dependent protein kinase II delta* / Mus musculus c...ENSDARG0000004301085
camk2b1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 / CAMK2B* / P28652* / Q13554* / calcium/calmodulin dependent protein kinase II beta* / Calcium/calmodulin-depend...ENSDARG0000001106584
camk2g2 / calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2 / CAMK2G* / Q13555* / Q923T9* / calcium/calmodulin dependent protein kinase II gamma* / Calcium/calmodulin-depe...ENSDARG0000005620682
camk2g1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 / CAMK2G* / Q13555* / Q923T9* / calcium/calmodulin dependent protein kinase II gamma* / Calcium/calmodulin-depe...ENSDARG0000007139581
camk2b2 / calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2 / CAMK2B* / P28652* / Q13554* / calcium/calmodulin dependent protein kinase II beta* / Calcium/calmodulin-depend...ENSDARG0000010008959
si:ch73-60h1.1ENSDARG0000007850431
camk1b / calcium/calmodulin-dependent protein kinase Ib / CAMK1* / Q14012* / Q91YS8* / calcium/calmodulin dependent protein kinase I*ENSDARG0000002947428
camk1da / calcium/calmodulin-dependent protein kinase 1Da / CAMK1D* / Q8BW96* / Q8IU85* / calcium/calmodulin dependent protein kinase ID*ENSDARG0000007490528
camk1db / calcium/calmodulin-dependent protein kinase 1Db / CAMK1D* / Q8BW96* / Q8IU85* / calcium/calmodulin dependent protein kinase ID*ENSDARG0000001744628
camk1gb / calcium/calmodulin-dependent protein kinase IGb / Q96NX5* / CAMK1G* / Q91VB2* / calcium/calmodulin dependent protein kinase IG* / Calcium/calmodulin-dependent protein kinase type 1G *ENSDARG0000000878828
camk1ga / calcium/calmodulin-dependent protein kinase IGa / Q96NX5* / CAMK1G* / Q91VB2* / calcium/calmodulin dependent protein kinase IG* / Calcium/calmodulin-dependent protein kinase type 1G *ENSDARG0000004452628
camk4 / calcium/calmodulin-dependent protein kinase IV / Q16566*ENSDARG0000000537227
camk1a / calcium/calmodulin-dependent protein kinase Ia / CAMK1* / Q14012* / Q91YS8* / calcium/calmodulin dependent protein kinase I*ENSDARG0000006011627
camkvl / CaM kinase-like vesicle-associated, likeENSDARG0000005700024
pnck / pregnancy up-regulated nonubiquitous CaM kinase / Q6P2M8* / Q9QYK9* / pregnancy upregulated non-ubiquitously expressed CaM kinase*ENSDARG0000004364824
Q7SY49 / camkvb / CaM kinase-like vesicle-associated b / CAMKV* / Q8NCB2* / Q3UHL1* / CaM kinase like vesicle associated* / CaM kinase-like vesicle-associated protein *ENSDARG0000000514123
pskh1 / Q501V0 / protein serine kinase H1 / P11801* / Q91YA2*ENSDARG0000005671323
camkva / CaM kinase-like vesicle-associated a / CAMKV* / Q8NCB2* / Q3UHL1* / CaM kinase like vesicle associated* / CaM kinase-like vesicle-associated protein *ENSDARG0000002796323
si:ch211-27e6.1 / PSKH2* / Q96QS6* / protein serine kinase H2*ENSDARG0000009989821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013543  Calcium/calmodulin-dependent protein kinase II, association-domain
 IPR017441  Protein kinase, ATP binding site
 IPR020636  Calcium/calmodulin-dependent/calcium-dependent protein kinase
 IPR032710  NTF2-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0046777 protein autophosphorylation IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IMP
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
HSF1-dependent transactivation
Ca2+ pathway
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF/MAP kinase cascade
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased size , abnormal
Kupffers vesicle cilium decreased length , abnormal
Show

 ZFA:0000339 digestive system digestive system inverted , abnormal
digestive system centered , abnormal
Show

 ZFA:0000360 heart tube heart tube inverted , abnormal
heart tube centered , abnormal
Show

 ZFA:0000509 epithalamus epithalamus inverted , abnormal
epithalamus aplastic , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased size , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
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 ZFA:0009149 Mauthner neuron Mauthner neuron NMDA glutamate receptor activity decreased duration , abnormal
Mauthner neuron NMDA glutamate receptor activity decreased process quality , abnormal
Mauthner neuron dendrite increased branchiness , abnormal
Mauthner neuron dendrite morphogenesis process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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