ENSMUSG00000024617


Mus musculus

Features
Gene ID: ENSMUSG00000024617
  
Biological name :Camk2a
  
Synonyms : Calcium/calmodulin-dependent protein kinase type II subunit alpha / Camk2a / P11798
  
Possible biological names infered from orthology : calcium/calmodulin dependent protein kinase II alpha / Q9UQM7
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E1
Gene start: 60925618
Gene end: 60988152
  
Corresponding Affymetrix probe sets: 10456021 (MoGene1.0st)   1437125_at (Mouse Genome 430 2.0 Array)   1441734_at (Mouse Genome 430 2.0 Array)   1442707_at (Mouse Genome 430 2.0 Array)   1452453_a_at (Mouse Genome 430 2.0 Array)   1457311_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123480
Ensembl peptide - ENSMUSP00000110950
Ensembl peptide - ENSMUSP00000110952
Ensembl peptide - ENSMUSP00000025519
Ensembl peptide - ENSMUSP00000048325
Ensembl peptide - ENSMUSP00000099952
NCBI entrez gene - 12322     See in Manteia.
MGI - MGI:88256
RefSeq - XM_017317805
RefSeq - NM_001286809
RefSeq - NM_009792
RefSeq - NM_177407
RefSeq - XM_006525541
RefSeq Peptide - NP_033922
RefSeq Peptide - NP_001273738
RefSeq Peptide - NP_803126
swissprot - F8WIS9
swissprot - F6WHR9
swissprot - F8WHB5
swissprot - D3Z7K9
swissprot - P11798
Ensembl - ENSMUSG00000024617
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 camk2aENSDARG00000053617Danio rerio
 CAMK2AENSGALG00000005621Gallus gallus
 CAMK2AENSG00000070808Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*ENSMUSG0000005381987
Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*ENSMUSG0000005789785
Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*ENSMUSG0000002182084
Camk1g / Q91VB2 / Calcium/calmodulin-dependent protein kinase type 1G / Q96NX5* / calcium/calmodulin dependent protein kinase IG*ENSMUSG0000001617929
Camk4 / calcium/calmodulin-dependent protein kinase IV / Q16566*ENSMUSG0000003812829
Camk1 / Q91YS8 / calcium/calmodulin-dependent protein kinase I / Q14012*ENSMUSG0000003027228
Pnck / Q9QYK9 / pregnancy upregulated non-ubiquitously expressed CaM kinase / Q6P2M8* / pregnancy up-regulated nonubiquitous CaM kinase*ENSMUSG0000000201228
Camk1d / Q8BW96 / calcium/calmodulin-dependent protein kinase ID / Q8IU85*ENSMUSG0000003914527
Camkv / Q3UHL1 / CaM kinase-like vesicle-associated protein / Q8NCB2* / CaM kinase like vesicle associated*ENSMUSG0000003293624
Pskh1 / Q91YA2 / protein serine kinase H1 / P11801*ENSMUSG0000004831023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013543  Calcium/calmodulin-dependent protein kinase II, association-domain
 IPR017441  Protein kinase, ATP binding site
 IPR032710  NTF2-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0002931 response to ischemia IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0038166 angiotensin-activated signaling pathway ISO
 biological_processGO:0046777 protein autophosphorylation IMP
 biological_processGO:0046928 regulation of neurotransmitter secretion IMP
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IMP
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051928 positive regulation of calcium ion transport IMP
 biological_processGO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IMP
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IDA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035254 glutamate receptor binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HSF1-dependent transactivation
Trafficking of AMPA receptors
Ca2+ pathway
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF/MAP kinase cascade
Interferon gamma signaling
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Camk2atm1.1Oyam/Camk2atm1.1Oyam
Genetic Background: either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

Allelic Composition: Camk2atm1.1Oyam/Camk2a+
Genetic Background: either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

 MP:0000973 abnormal cutaneous/subcutaneous mechanoreceptor morphology "malformed receptors that respond to mechanical pressure or distortion in the skin" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Camk2atm1Sva/Camk2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Camk2atm1Sva/Camk2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Camk2atm1Mllr/Camk2atm1Mllr
Genetic Background: B6.129-Camk2atm1Mllr

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Camk2atm1.1Oyam/Camk2atm1.1Oyam
Genetic Background: either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

Allelic Composition: Camk2atm1.1Oyam/Camk2a+
Genetic Background: either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Camk2atm1Mllr/Camk2atm1Mllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Camk2atm1Mllr/Camk2atm1Mllr
Genetic Background: B6.129-Camk2atm1Mllr

 MP:0001462 abnormal avoidance learning behavior "defects in the ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Camk2atm1.1Oyam/Camk2atm1.1Oyam
Genetic Background: either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Camk2atm5Sva/Camk2atm5Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Camk2atm4Sva/Camk2atm4Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Camk2atm5Sva/Camk2atm5Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Camk2atm1Mllr/Camk2atm1Mllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Camk2atm1Mllr/Camk2atm1Mllr
Genetic Background: B6.129-Camk2atm1Mllr

Allelic Composition: Camk2atm1.1Oyam/Camk2atm1.1Oyam
Genetic Background: either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Camk2atm5Sva/Camk2atm5Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Camk2atm4Sva/Camk2atm4Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Camk2atm5Sva/Camk2atm5Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Camk2atm1Mllr/Camk2atm1Mllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Camk2atm1Mllr/Camk2atm1Mllr
Genetic Background: B6.129-Camk2atm1Mllr

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: PhexHyp/Y
Genetic Background: B6.Cg-PhexHyp/J

Allelic Composition: Camk2atm3Sva/Camk2atm3Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Camk2atm5Sva/Camk2atm5Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Camk2atm3Sva/Camk2atm3Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Camk2atm5Sva/Camk2atm5Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Camk2atm5Sva/Camk2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Camk2atm1Sva/Camk2atm1Sva
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Camk2atm1.1Oyam/Camk2atm1.1Oyam
Genetic Background: either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

Allelic Composition: Camk2atm1.1Yelg/Camk2atm1.1Yelg,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: B6J.Cg-Camk2atm1.1Yelg Tg(CAG-cre/Esr1*)5Amc

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Camk2atm1Sva/Camk2atm1Sva
Genetic Background: involves: 129P2/OlaHsd

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Camk2atm5Sva/Camk2atm5Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: PhexHyp/Y
Genetic Background: B6.Cg-PhexHyp/J

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmdmdx/Y,Utrntm1Jrs/Utrn+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Camk2atm3Sva/Camk2atm3Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Camk2atm5Sva/Camk2atm5Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Camk2atm1.1Oyam/Camk2a+
Genetic Background: either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Camk2atm1Sva/Camk2atm1Sva
Genetic Background: involves: 129P2/OlaHsd

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Camk2atm4Sva/Camk2atm4Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Camk2atm1Mllr/Camk2atm1Mllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Camk2atm1Mllr/Camk2atm1Mllr
Genetic Background: B6.129-Camk2atm1Mllr

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Camk2atm1.1Oyam/Camk2atm1.1Oyam
Genetic Background: either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Camk2atm1Sva/Camk2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Camk2atm3Sva/Camk2atm3Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Camk2atm1Sva/Camk2atm1Sva
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Camk2atm3Sva/Camk2atm3Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Camk2atm4Sva/Camk2atm4Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk2atm3Sva/Camk2atm3Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk2atm3Sva/Camk2atm3Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk2atm3Sva/Camk2atm3Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Camk2atm1Sva/Camk2atm1Sva
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Camk2atm1Sva/Camk2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk2atm1Sva/Camk2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008431 abnormal short-term spatial reference memory "anomaly in the short-term memory for spatial location information that is established during the first few minutes after training or an encouter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk2atm1.1Oyam/Camk2atm1.1Oyam
Genetic Background: either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk2atm1.1Oyam/Camk2atm1.1Oyam
Genetic Background: either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

Allelic Composition: Camk2atm1.1Oyam/Camk2a+
Genetic Background: either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk2atm1.1Yelg/Camk2atm1.1Yelg,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: B6J.Cg-Camk2atm1.1Yelg Tg(CAG-cre/Esr1*)5Amc

Allelic Composition: Camk2atm1.1Yelg/Camk2atm1.1Yelg,Emx1tm1.1(cre)Ito/0
Genetic Background: B6J.Cg-Camk2atm1.1Yelg Emx1tm1.1(cre)Ito

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Camk2atm1.1Yelg/Camk2atm1.1Yelg,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: B6J.Cg-Camk2atm1.1Yelg Tg(CAG-cre/Esr1*)5Amc

Allelic Composition: Camk2atm1.1Yelg/Camk2atm1.1Yelg,Emx1tm1.1(cre)Ito/0
Genetic Background: B6J.Cg-Camk2atm1.1Yelg Emx1tm1.1(cre)Ito

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / reaction / complex
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / reaction / complex
 ENSMUSG00000020734 Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*  / reaction / complex
 ENSMUSG00000002771 Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*  / reaction / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / complex / reaction
 ENSMUSG00000022965 Ifngr2 / interferon gamma receptor 2 / P38484*  / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / complex / reaction
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / reaction
 ENSMUSG00000032356 P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*  / reaction / complex
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction / complex
 ENSMUSG00000038387 Rras / P10833 / related RAS viral (r-ras) oncogene / P10301* / RAS related*  / reaction
 ENSMUSG00000020009 Ifngr1 / P15261 / interferon gamma receptor 1 / P15260*  / reaction
 ENSMUSG00000059003 Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction / complex
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex / reaction
 ENSMUSG00000055170 Ifng / P01580 / Interferon gamma / P01579*  / reaction
 ENSMUSG00000025958 Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*  / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000025892 Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSMUSG00000022055 Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*  / complex / reaction
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / reaction / complex
 ENSMUSG00000052374 Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*  / reaction / complex
 ENSMUSG00000001986 Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*  / reaction






 

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