ENSMUSG00000022965


Mus musculus

Features
Gene ID: ENSMUSG00000022965
  
Biological name :Ifngr2
  
Synonyms : Ifngr2 / interferon gamma receptor 2
  
Possible biological names infered from orthology : P38484
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C3.3
Gene start: 91547072
Gene end: 91565169
  
Corresponding Affymetrix probe sets: 10436865 (MoGene1.0st)   1423557_at (Mouse Genome 430 2.0 Array)   1423558_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119580
Ensembl peptide - ENSMUSP00000023687
NCBI entrez gene - 15980     See in Manteia.
MGI - MGI:107654
RefSeq - NM_008338
RefSeq Peptide - NP_032364
swissprot - D6RIP6
swissprot - Q63953
Ensembl - ENSMUSG00000022965
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IFNGR2ENSGALG00000032660Gallus gallus
 IFNGR2ENSG00000159128Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il10rb / Q08334* / interleukin 10 receptor subunit beta*ENSMUSG0000002296920
Ifnar1 / P33896 / Interferon alpha/beta receptor 1 / P17181* / interferon alpha and beta receptor subunit 1*ENSMUSG0000002296718
Gm21970 / IL10RB* / Q08334* / interleukin 10 receptor subunit beta*ENSMUSG0000009370115


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0051607 defense response to virus IMP
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004920 interleukin-10 receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Interferon gamma signaling
Regulation of IFNG signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / reaction
 ENSMUSG00000020009 Ifngr1 / P15261 / interferon gamma receptor 1 / P15260*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex
 ENSMUSG00000021948 Prkcd / P28867 / protein kinase C, delta / Q05655*  / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSMUSG00000022965 Ifngr2 / interferon gamma receptor 2 / P38484*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000038037 Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*  / reaction / complex
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / reaction / complex
 ENSMUSG00000055170 Ifng / P01580 / Interferon gamma / P01579*  / reaction / complex






 

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