ENSMUSG00000021820


Mus musculus

Features
Gene ID: ENSMUSG00000021820
  
Biological name :Camk2g
  
Synonyms : Calcium/calmodulin-dependent protein kinase type II subunit gamma / Camk2g / Q923T9
  
Possible biological names infered from orthology : calcium/calmodulin dependent protein kinase II gamma / Q13555
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A3
Gene start: 20734875
Gene end: 20794088
  
Corresponding Affymetrix probe sets: 10417972 (MoGene1.0st)   1423941_at (Mouse Genome 430 2.0 Array)   1423942_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152992
Ensembl peptide - ENSMUSP00000152903
Ensembl peptide - ENSMUSP00000153007
Ensembl peptide - ENSMUSP00000154158
Ensembl peptide - ENSMUSP00000153471
Ensembl peptide - ENSMUSP00000153453
Ensembl peptide - ENSMUSP00000153165
Ensembl peptide - ENSMUSP00000071720
Ensembl peptide - ENSMUSP00000079298
Ensembl peptide - ENSMUSP00000098398
NCBI entrez gene - 12325     See in Manteia.
MGI - MGI:88259
RefSeq - XM_017315828
RefSeq - XM_006518491
RefSeq - XM_006518492
RefSeq - XM_006518493
RefSeq - XM_006518494
RefSeq - XM_006518495
RefSeq - XM_006518496
RefSeq - XM_006518497
RefSeq - XM_006518498
RefSeq - XM_006518500
RefSeq - XM_017315826
RefSeq - XM_017315827
RefSeq - NM_001039138
RefSeq - NM_001039139
RefSeq - NM_178597
RefSeq - XM_006518488
RefSeq - XM_006518489
RefSeq - XM_006518490
RefSeq Peptide - NP_001034227
RefSeq Peptide - NP_001034228
RefSeq Peptide - NP_848712
swissprot - A0A286YCI7
swissprot - A0A286YCH4
swissprot - A0A286YDL6
swissprot - Q923T9
swissprot - A0A286YCB8
swissprot - Q6ZWS7
swissprot - A0A286YDK9
swissprot - A0A286YCW8
Ensembl - ENSMUSG00000021820
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 camk2g1ENSDARG00000071395Danio rerio
 camk2g2ENSDARG00000056206Danio rerio
 CAMK2GENSGALG00000005088Gallus gallus
 CAMK2GENSG00000148660Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*ENSMUSG0000005789784
Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*ENSMUSG0000005381983
Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*ENSMUSG0000002461776
Camk4 / calcium/calmodulin-dependent protein kinase IV / Q16566*ENSMUSG0000003812827
Camk1g / Q91VB2 / Calcium/calmodulin-dependent protein kinase type 1G / Q96NX5* / calcium/calmodulin dependent protein kinase IG*ENSMUSG0000001617927
Camk1 / Q91YS8 / calcium/calmodulin-dependent protein kinase I / Q14012*ENSMUSG0000003027226
Pnck / Q9QYK9 / pregnancy upregulated non-ubiquitously expressed CaM kinase / Q6P2M8* / pregnancy up-regulated nonubiquitous CaM kinase*ENSMUSG0000000201225
Camk1d / Q8BW96 / calcium/calmodulin-dependent protein kinase ID / Q8IU85*ENSMUSG0000003914525
Camkv / Q3UHL1 / CaM kinase-like vesicle-associated protein / Q8NCB2* / CaM kinase like vesicle associated*ENSMUSG0000003293622
Pskh1 / Q91YA2 / protein serine kinase H1 / P11801*ENSMUSG0000004831021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013543  Calcium/calmodulin-dependent protein kinase II, association-domain
 IPR017441  Protein kinase, ATP binding site
 IPR032710  NTF2-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0046777 protein autophosphorylation IMP
 biological_processGO:0051259 protein complex oligomerization ISO
 biological_processGO:1901897 regulation of relaxation of cardiac muscle IGI
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IMP
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO


Pathways (from Reactome)
Pathway description
HSF1-dependent transactivation
Trafficking of AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF/MAP kinase cascade
Interferon gamma signaling
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011081 decreased macrophage apoptosis "reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0013298 increased susceptibility to colitis induced morbidity/mortality " increased likelihood that an organism will display the expected moribund state caused by colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:Annie_Speak]
Show

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex / reaction
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / reaction / complex
 ENSMUSG00000020734 Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*  / reaction / complex
 ENSMUSG00000002771 Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*  / reaction / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / reaction / complex
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / complex / reaction
 ENSMUSG00000025892 Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSMUSG00000022055 Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*  / reaction / complex
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSMUSG00000059003 Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*  / reaction / complex
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / reaction / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction / complex
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / reaction
 ENSMUSG00000032356 P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction
 ENSMUSG00000022965 Ifngr2 / interferon gamma receptor 2 / P38484*  / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction / complex
 ENSMUSG00000020009 Ifngr1 / P15261 / interferon gamma receptor 1 / P15260*  / reaction
 ENSMUSG00000038387 Rras / P10833 / related RAS viral (r-ras) oncogene / P10301* / RAS related*  / reaction
 ENSMUSG00000055170 Ifng / P01580 / Interferon gamma / P01579*  / reaction
 ENSMUSG00000025958 Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*  / reaction
 ENSMUSG00000052374 Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*  / complex / reaction
 ENSMUSG00000001986 Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*  / reaction






 

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