ENSMUSG00000055170


Mus musculus

Features
Gene ID: ENSMUSG00000055170
  
Biological name :Ifng
  
Synonyms : Ifng / Interferon gamma / P01580
  
Possible biological names infered from orthology : P01579
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D2
Gene start: 118441046
Gene end: 118445892
  
Corresponding Affymetrix probe sets: 10366586 (MoGene1.0st)   1425947_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063800
NCBI entrez gene - 15978     See in Manteia.
MGI - MGI:107656
RefSeq - NM_008337
RefSeq Peptide - NP_032363
swissprot - P01580
Ensembl - ENSMUSG00000055170
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IFNGENSGALG00000009903Gallus gallus
 IFNGENSG00000111537Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002069  Interferon gamma
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation ISO
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001781 neutrophil apoptotic process IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0002026 regulation of the force of heart contraction IEA
 biological_processGO:0002250 adaptive immune response IDA
 biological_processGO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response IDA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006925 inflammatory cell apoptotic process IMP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006959 humoral immune response IDA
 biological_processGO:0007050 cell cycle arrest ISO
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009615 response to virus ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010508 positive regulation of autophagy ISS
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010634 positive regulation of epithelial cell migration ISO
 biological_processGO:0010835 regulation of protein ADP-ribosylation ISO
 biological_processGO:0019882 antigen processing and presentation IDA
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0030857 negative regulation of epithelial cell differentiation IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IDA
 biological_processGO:0031334 positive regulation of protein complex assembly ISO
 biological_processGO:0031642 negative regulation of myelination IDA
 biological_processGO:0032224 positive regulation of synaptic transmission, cholinergic IEA
 biological_processGO:0032700 negative regulation of interleukin-17 production ISO
 biological_processGO:0032735 positive regulation of interleukin-12 production ISO
 biological_processGO:0032747 positive regulation of interleukin-23 production ISO
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0032834 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response ISO
 biological_processGO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein IEA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation ISO
 biological_processGO:0034393 positive regulation of smooth muscle cell apoptotic process ISO
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042742 defense response to bacterium IDA
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IMP
 biological_processGO:0044146 negative regulation of growth of symbiont involved in interaction with host IDA
 biological_processGO:0045080 positive regulation of chemokine biosynthetic process IMP
 biological_processGO:0045084 positive regulation of interleukin-12 biosynthetic process IDA
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process IEA
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process IMP
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISO
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation ISO
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEA
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IDA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation ISO
 biological_processGO:0050691 regulation of defense response to virus by host IDA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IMP
 biological_processGO:0050776 regulation of immune response IDA
 biological_processGO:0050796 regulation of insulin secretion ISO
 biological_processGO:0050852 T cell receptor signaling pathway IDA
 biological_processGO:0050954 sensory perception of mechanical stimulus IEA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis ISO
 biological_processGO:0051607 defense response to virus IGI
 biological_processGO:0051712 positive regulation of killing of cells of other organism ISO
 biological_processGO:0060251 regulation of glial cell proliferation IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway IDA
 biological_processGO:0060550 positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity ISO
 biological_processGO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process ISO
 biological_processGO:0060557 positive regulation of vitamin D biosynthetic process ISO
 biological_processGO:0060559 positive regulation of calcidiol 1-monooxygenase activity ISO
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071351 cellular response to interleukin-18 IDA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity ISO
 biological_processGO:0072125 negative regulation of glomerular mesangial cell proliferation IEA
 biological_processGO:0090312 positive regulation of protein deacetylation IDA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 biological_processGO:0098908 regulation of neuronal action potential IEA
 biological_processGO:1904798 positive regulation of core promoter binding ISO
 biological_processGO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production ISO
 biological_processGO:2000345 regulation of hepatocyte proliferation IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005133 interferon-gamma receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interferon gamma signaling
Regulation of IFNG signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Olfr151tm32Mom/Olfr151tm32Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0000701 abnormal lymph node size "deviation from the normal lymph node size " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B10.129P2(B6)-Il10tm1Cgn/J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129-Apoetm1Unc Ifngtm1Ts

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129-Ifngtm1Ts Tgfb1tm1Doe

 MP:0001272 increased metastatic potential 
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Olfr151tm32Mom/Olfr151tm32Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7-Ifngtm1Ts

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Olfr151tm32Mom/Olfr151tm32Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7-Ifngtm1Ts

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lcp2tm1Gak/Lcp2tm2Gak,Tg(Vav1-cre)1Graf/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il18tm1Aki/Il18tm1Aki,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129-Ifngtm1Ts Tgfb1tm1Doe

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * BALB/c

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001884 mammary alveolar hyperplasia 
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Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0001942 abnormal lung volume "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * BALB/c

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.Cg-Prf1tm1Sdz Ifngtm1Ts

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7-Ifngtm1Ts

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Mlg Il3tm1Glli

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: C.129S2-Csf2tm1Dran Il3tm1Glli

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129-Ifngtm1Ts Tgfb1tm1Doe

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

Allelic Composition: Ifngtm1Ts/Ifng+,Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.Cg-Prf1tm1Sdz Ifngtm1Ts

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: C.129S4-Ifngtm3.1Lky

Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: B6.129S4-Ifngtm3.1Lky

 MP:0002224 abnormal spleen size "deviation from the normal spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B10.129P2(B6)-Il10tm1Cgn/J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * BALB/c

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0002343 abnormal lymph node cortex "anomaly in the outer area of the lymph node that has B and T cell domains" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002345 abnormal lymph node primary follicle "anomaly in the immunologically inactive B cell area of the lymph node cortex" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002346 abnormal lymph node secondary follicle "anomaly in the immunologically active area of the lymph node cortex " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0002425 altered susceptibility to autoimmune disorder "a change in the likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Flt1tm1Gne/Flt1tm1Gne
Genetic Background: Not Specified

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7-Ifngtm1Ts

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * BALB/c

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

 MP:0002534 type IV hypersensitivity reaction "an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129-Ifngtm1Ts Tgfb1tm1Doe

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7-Ifngtm1Ts

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.Cg-Prf1tm1Sdz Ifngtm1Ts

 MP:0003459 increased fear-related response "greater emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts Prkdcscid

 MP:0003579 ovarian carcinoma 
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0003699 abnormal female reproductive system physiology "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

 MP:0003726 decreased autoantibody level "reduced level of antibodies to self-antigens present in the sera" [acv:Alicia Valenzuela, Genetic Resources Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0004752 decreased length of allograft survival "compared to controls, a reduced length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0004795 decreased anti-nuclear antigen antibody level "reduced level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0004798 decreased anti-double stranded DNA antibody level "reduced level of antibodies to double stranded DNA present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7-Ifngtm1Ts

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts Prkdcscid

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts/DvsJ

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0005000 immune tolerance "the failure to respond to an antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Olfr151tm32Mom/Olfr151tm32Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7-Ifngtm1Ts

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7-Ifngtm1Ts

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7-Ifngtm1Ts

 MP:0005040 abnormal MHC II cell surface expression on macrophages "anomaly in the ability of macrophages to express major histocompatibility complex class II at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31326]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts Prkdcscid

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129-Ifngtm1Ts Tgfb1tm1Doe

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0005351 decreased susceptibility to autoimmune disorders "reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * A/WySn * C57BL/10SnSg * Swiss

 MP:0005362 abnormal Langerhans cell physiology "atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0008054 abnormal uterine NK cell morphology "any structural anomaly of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Ifngtm1Ts/Ifngtm1Ts,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Ifngtm1Ts/Ifngtm1Ts,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * A/WySn * C57BL/10SnSg * Swiss

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * A/WySn * C57BL/10SnSg * Swiss

 MP:0008523 absent lymph node germinal center "absence of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Socs1tm1Jni/Socs1tm1Jni
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7-Ifngtm1Ts

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifng+,Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * A/WySn * C57BL/10SnSg * Swiss

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0009099 abnormal uterine NK cell physiology "any structural anomaly of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; uNK cells contribute to uterine decidualization and are recruited to implantation sites" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", PMID:12887272]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0009246 pale spleen "spleen lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0009336 increased splenocyte proliferation "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

 MP:0009394 increased uterine NK cell number "increased number of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; uNK cells contribute to uterine decidualization and are recruited to implantation sites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129-Apoetm1Unc Ifngtm1Ts

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7-Ifngtm1Ts

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7-Ifngtm1Ts

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.Cg-Prf1tm1Sdz Ifngtm1Ts

 MP:0010574 aorta dilation "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129-Apoetm1Unc Ifngtm1Ts

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0010659 abdominal aorta aneurysm "a protruding sac formed by the dilation of the wall of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129-Apoetm1Unc Ifngtm1Ts

 MP:0010740 abnormal dendritic cell chemotaxis "anomaly in the movement of a dendritic cell in response to an external stimulus" [GO:0002407]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0010750 increased susceptibility to parasitic infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7-Ifngtm1Ts

 MP:0010751 decreased susceptibility to parasitic infection induced morbidity/mortality "decreased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: C.129S7(B6)-Ifngtm1Ts/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.Cg-Prf1tm1Sdz Ifngtm1Ts

 MP:0013239 impaired skeletal muscle regeneration "reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts/J

 MP:0013414 decreased myeloid cell number in bone marrow "reduction in the number of CD45+ CD11b+ GR1- myeloid cells in the bone marrow" [IMPC:Saran]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0013590 enlarged thymus medulla "increased size of the inner area of thymus lobules" [MGI:Anna]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0013697 decreased granulocyte monocyte progenitor cell number "reduction in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0013705 decreased megakaryocyte-erythroid progenitor cell number "reduced number of a progenitor cell committed to the megakaryocyte and erythroid lineages" [CL:0000050]
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Allelic Composition: Ifngtm1.1Hayg/Ifngtm1.1Hayg
Genetic Background: Not Specified

 MP:0030466 alveolar process atrophy "acquired diminution of the size of the alveolar process associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / reaction
 ENSMUSG00000021948 Prkcd / P28867 / protein kinase C, delta / Q05655*  / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSMUSG00000038037 Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*  / complex / reaction
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000022965 Ifngr2 / interferon gamma receptor 2 / P38484*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000020009 Ifngr1 / P15261 / interferon gamma receptor 1 / P15260*  / reaction / complex
 ENSMUSG00000055170 Ifng / P01580 / Interferon gamma / P01579*  / complex






 

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