| MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
|
| MP:0000066 | osteoporosis | "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0000135 | reduced cortical bone thickness | "thinner than normal superficial layer of compact bone " [J:61509] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0000194 | hypercalcemia | "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
|
| MP:0000333 | decreased bone marrow cell number | "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0000694 | spleen hypoplasia | "small size due to reduced cell number in the spleen" [J:43971] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0000920 | abnormal myelination | "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified
|
| MP:0001120 | abnormal uterus morphology | "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
|
| MP:0001272 | increased metastatic potential | |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0001273 | decreased metastatic potential | |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0001541 | abnormal osteoclast function | "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795] |
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
|
| MP:0001545 | abnormal hematopoietic system physiology | "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0001606 | impaired hematopoiesis | "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Pik3cdm2Btlr/Pik3cd+
Genetic Background: C57BL/6J-Pik3cdm2Btlr
|
| MP:0001805 | decreased IgG | "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr
|
| MP:0001806 | decreased IgM | "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr
|
| MP:0001807 | decreased IgA | "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr
|
| MP:0001870 | salivary gland inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr
|
| MP:0001970 | abnormal pain threshold | "increased or decreased average level of perception of pain" [J:17792] |
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Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified
|
| MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
|
| MP:0002166 | altered tumor susceptibility/resistance | "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0002217 | small lymph nodes | "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr
Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr
|
| MP:0002401 | abnormal lymphopoiesis | "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0002411 | decreased susceptibility to bacterial infection | "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Ifngr1tm1.2Rds/Ifngr1tm1.2Rds
Genetic Background: C57BL/6NTac-Ifngr1tm1.2Rds
Allelic Composition: Ifngr1tm1.1Rds/Ifngr1tm1.1Rds,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: B6NTac.Cg-Ifngr1tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach
Allelic Composition: Ifngr1tm1.1Rds/Ifngr1tm1.1Rds,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6NTac.Cg-Ifngr1tm1.1Rds Commd10Tg(Vav1-icre)A2Kio
|
| MP:0002418 | increased susceptibility to viral infection | "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0002490 | abnormal circulating immunoglobulin concentration | "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
|
| MP:0002493 | increased IgG | "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr
Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr
|
| MP:0002743 | glomerulonephritis | "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr
Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr
|
| MP:0002962 | increased protein excretion | "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission] |
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr
Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr
|
| MP:0003332 | liver abscess | "collection of purulent exudate within the liver as a result of infection by bacteria, protozoa, or other agents " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
|
| MP:0003360 | depression-related behavior | |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0003724 | susceptibility to induced arthritis | "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator] |
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
|
| MP:0003726 | decreased autoantibody level | "reduced level of antibodies to self-antigens present in the sera" [acv:Alicia Valenzuela, Genetic Resources Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr
Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr
|
| MP:0003884 | decreased macrophage count | "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator] |
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Allelic Composition: Pik3cdm2Btlr/Pik3cd+
Genetic Background: C57BL/6J-Pik3cdm2Btlr
|
| MP:0003893 | increased hepatocyte proliferation | "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
|
| MP:0003980 | increased circulating phospholipid level | "greater concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
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| MP:0004003 | abnormal vascular endothelial cell physiology | "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
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| MP:0004256 | abnormal maternal decidual layer morphology | "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
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| MP:0004795 | decreased anti-nuclear antigen antibody level | "reduced level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr
Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr
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| MP:0004799 | increased susceptibility to experimental autoimmune encephalomyelitis | "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
|
| MP:0004801 | increased susceptibility to systemic lupus erythematosus | "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr
|
| MP:0004802 | decreased susceptibility to systemic lupus erythematosus | "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr
Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr
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| MP:0004821 | increased susceptibility to experimental autoimmune uveoretinitis | "greater likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0004824 | decreased susceptibility to experimental autoimmune myasthenia gravis | "reduced likelihood that an organism will develop disease symptoms similar to human myasthenia gravis upon induction with antigens to acetylcholine receptor subunits" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0004984 | increased osteoclast cell number | "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
|
| MP:0004989 | decreased osteoblast cell number | "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0004993 | decreased bone resorption | "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
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| MP:0005014 | increased B cell number | "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pik3cdm2Btlr/Pik3cd+
Genetic Background: C57BL/6J-Pik3cdm2Btlr
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| MP:0005016 | decreased lymphocyte number | "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0005025 | response to infection | "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
Allelic Composition: Ifngr1tm1Dmer/Ifngr1tm1Dmer
Genetic Background: B6.Cg-Ifngr1tm1Dmer
Allelic Composition: Ifngr1tm1Dmer/Ifngr1tm1Dmer,Tg(Thy1-cre)1Vln/0
Genetic Background: B6.Cg-Ifngr1tm1Dmer Tg(Thy1-cre)1Vln
|
| MP:0005027 | increased susceptibility to parasitic infection | "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
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| MP:0005078 | abnormal cytotoxic T cell physiology | "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0005178 | increased total circulating cholesterol level | "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cntnap1shm/Cntnap1shm
Genetic Background: SHM/Nem
|
| MP:0005341 | decreased susceptibility to atherosclerosis | "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
|
| MP:0005672 | increased susceptibility to graft versus host disease | "greater likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0008054 | abnormal uterine NK cell morphology | "any structural anomaly of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
|
| MP:0008075 | decreased CD4-positive T cell number | "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0008079 | decreased CD8-positive T cell number | "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
|
| MP:0008396 | abnormal osteoclast differentiation | "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt,Tg(GZMB-Tax)#Lera/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0008496 | decreased IgG2a level | "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * DBA/1OlaHsd
Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr
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| MP:0008497 | decreased IgG2b level | "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr
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| MP:0008498 | decreased IgG3 level | "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr
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| MP:0008499 | increased IgG1 level | "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr
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| MP:0008554 | decreased circulating tumor necrosis factor level | "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
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| MP:0008560 | increased tumor necrosis factor secretion | "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
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| MP:0008561 | decreased tumor necrosis factor secretion | "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Pik3cdm2Btlr/Pik3cd+
Genetic Background: C57BL/6J-Pik3cdm2Btlr
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| MP:0008566 | increased interferon-gamma secretion | "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: B6.129S7-Ifngr1tm1Agt/J
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| MP:0008567 | decreased interferon-gamma secretion | "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Ifngr1tm1.1Rds/Ifngr1tm1.1Rds,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: B6NTac.Cg-Ifngr1tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach
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| MP:0008578 | decreased circulating interferon-gamma level | "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
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| MP:0008596 | increased circulating interleukin-6 level | "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
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| MP:0008618 | decreased circulating interleukin-12 level | "reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: B6.129S7-Ifngr1tm1Agt/J
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| MP:0008670 | decreased interleukin-12b secretion | "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500] |
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Allelic Composition: Ifngr1tm1.2Rds/Ifngr1tm1.2Rds
Genetic Background: C57BL/6NTac-Ifngr1tm1.2Rds
Allelic Composition: Ifngr1tm1.1Rds/Ifngr1tm1.1Rds,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: B6NTac.Cg-Ifngr1tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach
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| MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0008721 | abnormal chemokine level | "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200] |
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CE/J
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| MP:0008734 | decreased susceptibility to endotoxin shock | "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
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| MP:0008874 | decreased sensitivity to xenobiotics | "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: T ts6/T+ t+
Genetic Background: Not Specified
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| MP:0009099 | abnormal uterine NK cell physiology | "any structural anomaly of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; uNK cells contribute to uterine decidualization and are recruited to implantation sites" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", PMID:12887272] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
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| MP:0009336 | increased splenocyte proliferation | "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0009346 | decreased cancellous bone thickness | "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: B6.129S7-Ifngr1tm1Agt/J
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| MP:0009394 | increased uterine NK cell number | "increased number of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; uNK cells contribute to uterine decidualization and are recruited to implantation sites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
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| MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: B6.129S7-Ifngr1tm1Agt/J
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| MP:0009788 | increased susceptibility to bacterial infection induced morbidity/mortality | "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
Allelic Composition: Ifngr1tm1.2Rds/Ifngr1tm1.2Rds
Genetic Background: C57BL/6NTac-Ifngr1tm1.2Rds
Allelic Composition: Ifngr1tm1.1Rds/Ifngr1tm1.1Rds,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: B6NTac.Cg-Ifngr1tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach
Allelic Composition: Ifngr1tm1.1Rds/Ifngr1tm1.1Rds,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6NTac.Cg-Ifngr1tm1.1Rds Commd10Tg(Vav1-icre)A2Kio
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| MP:0009791 | increased susceptibility to viral infection induced morbidity/mortality | "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0010138 | arteritis | "inflammation of the walls of arteries, usually as a result of infection or auto-immune response" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
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| MP:0010139 | aortitis | "inflammation of the aorta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
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| MP:0010144 | abnormal tumor vascularization | "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
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| MP:0010209 | abnormal circulating chemokine level | "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: B6.129S7-Ifngr1tm1Agt/J
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| MP:0010280 | increased skeletal tumor incidence | "greater than the expected number of neoplasms in the skeletal tissue, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt,Tg(GZMB-Tax)#Lera/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0010331 | abnormal apolipoprotein level | "anomaly in the amount of the a protein that is frequently a component of a lipoprotein complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
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| MP:0010869 | decreased bone trabecula number | "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: B6.129S7-Ifngr1tm1Agt/J
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| MP:0010876 | decreased bone volume | "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: B6.129S7-Ifngr1tm1Agt/J
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| MP:0011711 | decreased osteoblast differentiation | |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: B6.129S7-Ifngr1tm1Agt/J
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| MP:0011922 | abnormal circulating osteocalcin level | "aberrant concentration in the blood of this hormone secreted by osteoblasts which are found in bone and dentin" [MPD:Molly] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: B6.129S7-Ifngr1tm1Agt/J
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| MP:0020040 | decreased bone ossification | "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: B6.129S7-Ifngr1tm1Agt/J
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| MP:0020137 | decreased bone mineralization | "decrease in the rate at which minerals are deposited into bone" [] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: B6.129S7-Ifngr1tm1Agt/J
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| MP:0030483 | decreased osteocyte number | "reduction in the number of mature osteoblasts that have become embedded in the bone matrix (osteoid) in small cavities called lacunae and that extend cytoplasmic (dendritic) processes away from the cell body toward other osteocytes and neighboring cells in small channels called canaliculi" [MGI:anna] |
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: B6.129S7-Ifngr1tm1Agt/J
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