ENSMUSG00000021948


Mus musculus

Features
Gene ID: ENSMUSG00000021948
  
Biological name :Prkcd
  
Synonyms : P28867 / Prkcd / protein kinase C, delta
  
Possible biological names infered from orthology : Q05655
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 30595354
Gene end: 30626210
  
Corresponding Affymetrix probe sets: 10418410 (MoGene1.0st)   1422847_a_at (Mouse Genome 430 2.0 Array)   1442256_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022521
Ensembl peptide - ENSMUSP00000107821
Ensembl peptide - ENSMUSP00000107829
Ensembl peptide - ENSMUSP00000107830
Ensembl peptide - ENSMUSP00000107822
Ensembl peptide - ENSMUSP00000107825
Ensembl peptide - ENSMUSP00000107826
NCBI entrez gene - 18753     See in Manteia.
MGI - MGI:97598
RefSeq - XM_017315918
RefSeq - NM_001310682
RefSeq - NM_011103
RefSeq - XM_006518695
RefSeq - XM_006518697
RefSeq - XM_006518698
RefSeq Peptide - NP_001297611
RefSeq Peptide - NP_035233
swissprot - Q1MX43
swissprot - Q53YN4
swissprot - P28867
swissprot - Q1MX41
swissprot - Q1MX40
swissprot - Q1MX42
Ensembl - ENSMUSG00000021948
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkcdaENSDARG00000009208Danio rerio
 prkcdbENSDARG00000070651Danio rerio
 PRKCDENSGALG00000002016Gallus gallus
 PRKCDENSG00000163932Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677862
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503842
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110841
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288939
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096539
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881638
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764328
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905328
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969926
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172926
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997026
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405625
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591524
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786820


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014376  Protein kinase C, delta/epsilon/eta/theta types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR027436  Protein kinase C, delta
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016064 immunoglobulin mediated immune response IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016572 histone phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023021 termination of signal transduction IEA
 biological_processGO:0030837 negative regulation of actin filament polymerization IMP
 biological_processGO:0032079 positive regulation of endodeoxyribonuclease activity IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032613 interleukin-10 production IMP
 biological_processGO:0032615 interleukin-12 production IMP
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IEA
 biological_processGO:0035307 positive regulation of protein dephosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042100 B cell proliferation IMP
 biological_processGO:0042119 neutrophil activation IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IMP
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0051490 negative regulation of filopodium assembly IMP
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071447 cellular response to hydroperoxide IEA
 biological_processGO:0090331 negative regulation of platelet aggregation IMP
 biological_processGO:0090398 cellular senescence IEA
 biological_processGO:1900163 positive regulation of phospholipid scramblase activity IEA
 biological_processGO:1904385 cellular response to angiotensin IEA
 biological_processGO:2000304 positive regulation of ceramide biosynthetic process IEA
 biological_processGO:2000753 positive regulation of glucosylceramide catabolic process IEA
 biological_processGO:2000755 positive regulation of sphingomyelin catabolic process IEA
 biological_processGO:2001022 positive regulation of response to DNA damage stimulus IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016363 nuclear matrix IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004697 protein kinase C activity IDA
 molecular_functionGO:0004699 calcium-independent protein kinase C activity ISO
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
Neutrophil degranulation
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: B6.129P2-Prkcdtm1Qxu

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist2tm1(cre)Dor/Twist2+,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: B6.129P2-Prkcdtm1Qxu

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Mir140tm1.1Tkob/Mir140tm1.1Tkob,Pdgfratm8Sor/Pdgfratm8Sor,Tg(Col2a1-cre)1Rsjo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL

Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: B6.129P2-Prkcdtm1Qxu

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003075 response to CNS ischemic injury 
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0003991 arteriosclerosis "thickening, hardening and/or loss of elasticity of the walls of arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Twist2tm1(cre)Dor/Twist2+,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004829 increased anti-chromatin antibody level "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0005005 abnormal self tolerance "a defect in the normal lack of response to autologous (self) antigens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu,Tg(IghelMD4)4Ccg/0,Tg(ML5sHEL)5Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mir140tm1.1Tkob/Mir140tm1.1Tkob,Pdgfratm8Sor/Pdgfratm8Sor,Tg(Col2a1-cre)1Rsjo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL

Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: B6.129P2-Prkcdtm1Qxu

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005489 vascular smooth muscle cell hyperplasia "increased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:48446]
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Allelic Composition: Twist2tm1(cre)Dor/Twist2+,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Twist2tm1(cre)Dor/Twist2+,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008099 abnormal plasma cell differentiation "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008471 abnormal spleen primary B follicle morphology "any structural anomaly of the nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp" [PMID:17495967]
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Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu,Tg(IghelMD4)4Ccg/0,Tg(ML5sHEL)5Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu,Tg(IghelMD4)4Ccg/0,Tg(ML5sHEL)5Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: B6.129P2-Prkcdtm1Qxu

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction
 ENSMUSG00000024858 Grk2 / Q99MK8 / G protein-coupled receptor kinase 2 / P25098*  / reaction
 ENSMUSG00000026928 Card9 / A2AIV8 / Caspase recruitment domain-containing protein 9 / Q9H257* / caspase recruitment domain family member 9*  / reaction
 ENSMUSG00000020009 Ifngr1 / P15261 / interferon gamma receptor 1 / P15260*  / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction
 ENSMUSG00000055170 Ifng / P01580 / Interferon gamma / P01579*  / reaction
 ENSMUSG00000061878 Sphk1 / Q8CI15 / Sphingosine kinase 1 / Q9NYA1*  / reaction
 ENSMUSG00000040028 Elavl1 / P70372 / ELAV-like protein 1 / Q15717* / ELAV like RNA binding protein 1*  / reaction
 ENSMUSG00000022965 Ifngr2 / interferon gamma receptor 2 / P38484*  / reaction
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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