ENSMUSG00000052889


Mus musculus

Features
Gene ID: ENSMUSG00000052889
  
Biological name :Prkcb
  
Synonyms : P68404 / Prkcb / protein kinase C, beta
  
Possible biological names infered from orthology : P05771
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F2
Gene start: 122288751
Gene end: 122634402
  
Corresponding Affymetrix probe sets: 10557177 (MoGene1.0st)   1423478_at (Mouse Genome 430 2.0 Array)   1443144_at (Mouse Genome 430 2.0 Array)   1460419_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064812
Ensembl peptide - ENSMUSP00000070019
Ensembl peptide - ENSMUSP00000138788
NCBI entrez gene - 18751     See in Manteia.
MGI - MGI:97596
RefSeq - XM_011241695
RefSeq - NM_001316672
RefSeq - NM_008855
RefSeq Peptide - NP_032881
RefSeq Peptide - NP_001303601
swissprot - P68404
Ensembl - ENSMUSG00000052889
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkcbaENSDARG00000008723Danio rerio
 prkcbbENSDARG00000022254Danio rerio
 PRKCBENSGALG00000037943Gallus gallus
 PRKCBENSG00000166501Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096581
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881671
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503844
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110841
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194841
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677840
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764332
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905331
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172927
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969927
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405626
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591525
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997025
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014375  Protein kinase C, alpha/beta/gamma types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR034664  Classical Protein Kinase C beta, catalytic domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010829 negative regulation of glucose transmembrane transport IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0035408 histone H3-T6 phosphorylation ISO
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042113 B cell activation IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway ISS
 biological_processGO:0050853 B cell receptor signaling pathway IMP
 biological_processGO:0050861 positive regulation of B cell receptor signaling pathway IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0071322 cellular response to carbohydrate stimulus IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004697 protein kinase C activity IDA
 molecular_functionGO:0005080 protein kinase C binding ISO
 molecular_functionGO:0005246 calcium channel regulator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity ISS
 molecular_functionGO:0035403 histone kinase activity (H3-T6 specific) ISO
 molecular_functionGO:0042393 histone binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding ISS


Pathways (from Reactome)
Pathway description
Disinhibition of SNARE formation
Activation of NF-kappaB in B cells
Trafficking of GluR2-containing AMPA receptors
Depolymerisation of the Nuclear Lamina
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: involves: C57BL/6JSfdAnu

Allelic Composition: Prkcbtilc/Prkcb+
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

Allelic Composition: PrkcbM1Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM1Btlr

Allelic Composition: PrkcbM1Btlr/PrkcbM1Btlr
Genetic Background: C57BL/6J-PrkcbM1Btlr

Allelic Composition: PrkcbM1Btlr/PrkcbM1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: PrkcbM2Btlr/PrkcbM2Btlr
Genetic Background: C57BL/6J-PrkcbM2Btlr

Allelic Composition: PrkcbM2Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM2Btlr

Allelic Composition: PrkcbM3Btlr/PrkcbM3Btlr
Genetic Background: C57BL/6J-PrkcbM3Btlr

Allelic Composition: PrkcbM3Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM3Btlr

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: involves: C57BL/6JSfdAnu

Allelic Composition: Prkcbtilc/Prkcb+
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Prnptm2Edin/Prnptm2Edin
Genetic Background: B6.129P2-Prnptm2Edin

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: involves: C57BL/6JSfdAnu

Allelic Composition: Prkcbtilc/Prkcb+
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: PrkcbM2Btlr/PrkcbM2Btlr
Genetic Background: C57BL/6J-PrkcbM2Btlr

Allelic Composition: PrkcbM2Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM2Btlr

Allelic Composition: PrkcbM3Btlr/PrkcbM3Btlr
Genetic Background: C57BL/6J-PrkcbM3Btlr

Allelic Composition: PrkcbM3Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM3Btlr

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: PrkcbM2Btlr/PrkcbM2Btlr
Genetic Background: C57BL/6J-PrkcbM2Btlr

Allelic Composition: PrkcbM2Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM2Btlr

Allelic Composition: PrkcbM3Btlr/PrkcbM3Btlr
Genetic Background: C57BL/6J-PrkcbM3Btlr

Allelic Composition: PrkcbM3Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM3Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction
 ENSMUSG00000028063 Lmna / P48678 / Prelamin-A/C Lamin-A/C / P02545* / lamin A/C*  / reaction
 ENSMUSG00000061878 Sphk1 / Q8CI15 / Sphingosine kinase 1 / Q9NYA1*  / reaction
 ENSMUSG00000027882 Q60770 / Stxbp3 / Syntaxin-binding protein 3 / O00186*  / reaction
 ENSMUSG00000001964 Emd / O08579 / Emerin / P50402*  / reaction
 ENSMUSG00000030805 Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*  / reaction






 

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